Core B: Clinical Resource Core

核心B：摘要/摘要 临床资源核心(CRC；核心B)将为人类受试者项目I和III提供支持 密歇根大学(U-M)Udall中心通过招聘、注册和详细的临床评估 帕金森病(PD)受试者和年龄和性别匹配的对照组(NC)。的一项独特功能 U-M Udall中心的建议是，它将利用独特的深度临床和神经成像表型PD 我们以前的尤德尔中心的人口(2014年9月8日至2020年8月)。帕金森病受试者的综合队列 在上一个U-M Udall中心周期中进行评估的人员将被招募进行额外的纵向评估 新帕金森病受试者的补充队列。CRC有标准化的数据收集、录入和处理方法 由生物统计和数据管理核心(BDMC；核心D)开发的验证符合 HIPAA和IRB法规。收集的数据与NINDS通用数据元素一致，以便于传输 使用ProFORMS将数据存储到NINDS数据管理存储库。启联将与 神经成像资源核心(NRC；核心C)，以协调受试者的体内神经成像评估。 儿童权利中心将作为项目III和荷兰帕金森病调查人员之间的联络人，并 认知(杜帕克)在格罗宁根大学的研究(P.I.Tus van Laar博士)。儿童基金会将继续 促进与太平洋尤德尔中心(P.I.托马斯·蒙廷博士)和加州大学的现有合作 罗切斯特·尤德尔中心(私家侦探雷·多尔西博士)《儿童权利公约》的具体目标是： 1.招募、招收和保留PD科目(净招生目标为N=100名符合条件的PD科目)和年龄--以及 U-M Udall中心项目I和III的性别匹配NC受试者(N=20)，以支持其科学研究 目标。 2.全面评估所有具有良好临床、运动功能和 基线和随访时的神经心理学工具。 3.为U-M Udall中心项目一和三提供组织结构和业务监督 并与其他核心进行交互和协调，以确保及时进行神经成像评估(NRC)和数据 转移和分析(BDMC)。 4.促进和协调来自格罗宁根大学杜帕克研究的数据传输。 5.支持与其他Udall中心的现有协作，并促进这些Udall中心之间的数据传输 中心

CORE B: SUMMARY/ABSTRACT The Clinical Resource Core (CRC; Core B) will provide support for human subjects Projects I and III of the University of Michigan (U-M) Udall Center through recruitment, enrollment, and detailed clinical assessment of Parkinson disease (PD) subjects and age- and gender-matched control (NC) subjects. A unique feature of the proposed U-M Udall Center is that it will leverage the unique deeply clinical and neuroimaging phenotyped PD population from our previous Udall Center (09/2014-08/2020). The cohort of PD subjects comprehensively assessed in the previous U-M Udall Center cycle will be recruited for additional longitudinal assessments with a supplemental cohort of new PD subjects. The CRC has standardized methods for data collection, entry, and verification, as developed by the Biostatistics and Data Management Core (BDMC; Core D), compliant with HIPAA and IRB regulations. Data collected is consistent with NINDS Common Data Elements to facilitate transfer of data to the NINDS Data Management Repository using ProFORMS. The CRC will closely collaborate with the Neuroimaging Resource Core (NRC; Core C) to coordinate in vivo neuroimaging assessments of subjects. The CRC will serve as the liaison between Project III and the investigators of the Dutch Parkinson and Cognition (DUPARC) study at the University of Groningen (P.I. Dr. Teus van Laar). The CRC will continue to foster existing collaborations with the Pacific Udall Center (P.I. Dr. Thomas Montine) and the University of Rochester Udall Center (P.I. Dr. Ray Dorsey). The specific goals of the CRC are: 1. To recruit, enroll, and retain PD subjects (net enrollment target of N=100 eligible PD subjects) and age- and gender-matched NC subjects (N=20) for the U-M Udall Center Projects I and III in support of their scientific goals. 2. To comprehensively assess all subjects with well-established clinical, motor function, and neuropsychological instruments at baseline and follow-up. 3. To provide the organizational structure and operations oversight for the U-M Udall Center Projects I and III and interact and coordinate with other Cores to assure prompt neuroimaging assessment (NRC) and data transfer and analysis (BDMC). 4. Facilitate and coordinate data transfer from the University of Groningen DUPARC study. 5. Support existing collaborations with other Udall Centers and facilitate transfer of data to and from these Udall Centers