TOPIC 417: GPU-ACCELERATED 3D MONTE CARLO SPECT RECONSTRUCTION ALGORITHM FOR PERSONALIZED RADIOPHARMACEUTICAL THERAPY

尽管放射性药物治疗（RPT）在淋巴瘤、晚期、转移性前列腺癌和神经内分泌肿瘤患者中效果良好，但众所周知，由于患者药代动力学的可变性，标准剂量导致临床结果难以预测且差异很大。然而，通过首先使用定量SPECT成像测量体内RPT剂释放的辐射，然后使用剂量学软件计算沉积在肿瘤和正常组织中的辐射能量，可以使RPT更安全、更有效。个性化的RPT处方可以使疗效最大化，副作用最小化。然而，由于商业上可用的SPECT重建算法不能准确地校正散射，它们不足以确定个性化的RPT处方。因此，有一个临床未满足的需要，更好的重建算法，使真正的定量SPECT成像。该合同提案的目的是建立一个图形处理单元（GPU）软件平台，该平台可以在5分钟内完成基于蒙特卡罗（MC）散射校正的SPECT重建，使其具有临床可行性。快速准确的基于GPU MC的SPECT重建（Torch Recon）将进一步提高RPT剂量测定的准确性，从而加快我们目前由sbirr资助的MC剂量引擎（Torch）的临床应用。

Although radiopharmaceutical therapy (RPT) has worked well in patients with lymphoma, late-stage, metastatic prostate cancer, and neuroendocrine tumors, it is well known that because of variability in patient pharmacokinetics, standard dosing leads to clinical outcomes that are difficult to predict and drastically vary. However, it is possible to make RPT safer and more effective by first measuring the radiation emitted by the RPT agent in vivo using quantitative SPECT imaging and then calculating the radiation energy deposited in tumors and normal tissues using dosimetry software. A personalized RPT prescription can be derived that maximizes effectiveness and minimizes side effects. However, because commercially available SPECT reconstruction algorithms do not accurately correct for scatter, they are insufficient for determining personalized RPT prescriptions. Therefore, there is a clinically unmet need for better reconstruction algorithms which enable true quantitative SPECT imaging. The aim of this contract proposal is to build a graphics processing unit (GPU) software platform that can perform SPECT reconstruction with Monte Carlo (MC)-based scatter correction within 5 minutes, making it clinically viable. Fast and accurate GPU MC-based SPECT reconstruction (Torch Recon) will further improve the accuracy of RPT dosimetry and thereby accelerate the clinical adoption of our current SBIR-funded MC dose engine (Torch).