GENOME CHARACTERIZATION CENTER RNA SEQUENCING IDIQ CONTRACT

基因组表征中心 RNA 测序 IDIQ 合同

• 批准号: 10503768
• 负责人: CORBIN JONES
• 金额: $ 92.05万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-08 至 2026-09-07
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10503768
• 关键词: Automation; Biocompatible Materials; Bioinformatics; Clinical; Contracts; Data; Freezing; Gene Expression Profiling; Genetic Transcription; Genome; Genomics; High-Throughput Nucleotide Sequencing; Informatics; Intake; Malignant Neoplasms; Methods; Molecular; National Cancer Institute; North Carolina; Performance; Procedures; Proteome; Proteomics; Protocols documentation; Quality Control; RNA; RNA analysis; Research; Resources; Role; Sampling; Services; Site; Small RNA; Technology; Tissues; Universities; data integration; data repository; experience; improved; mRNA sequencing; miRNA expression profiling; next generation sequencing; proteogenomics; transcriptome; transcriptome sequencing; tumor

The University of North Carolina at Chapel Hill (UNC) High-throughput Sequencing Facility and Integrated Genomics Core (HTSF and IGC) will extend its role as a Genome Characterization Center (GCC) for analysis of cancer-related samples to the Office of Cancer Clinical Proteomics Research (OCCPR) at the National Cancer Institute (NCI). The GCC team has all the capabilities—total RNAseq, transcriptome (mRNAseq), and miRNAseq—required for this project. We have established criterion and standard operating procedures (SOP) for intake of samples from BCRs; rigorous QAQC protocols; advanced methods, automation, and technology for comprehensive total RNA, mRNA, and miRNA sequencing; cutting-edge bioinformatic assessment; and extensive experience working with NCI data repositories. UNC is well poised to investigate, evaluate, and implement new genomic technology as it emerges. Finally, we have an extensive track record of more than 15 years of performing transcriptional characterization of cancer related samples.

北卡罗来纳大学教堂山分校（University of North Carolina at查佩尔山，简称UCC）的高通量测序设施和综合基因组学核心（Integrated Genomics Core，简称HTSF和IGC）将把其作为基因组表征中心（Genome Characterization Center，简称GCC）的角色扩展到国家癌症研究所（National Cancer Institute，简称NCI）的癌症临床蛋白质组学研究办公室（Office of Cancer Clinical Proteomics Research，简称OCCPR），用于分析癌症相关样本。GCC团队拥有该项目所需的所有功能-总RNAseq，转录组（mRNAseq）和miRNAseq。我们已经建立了从BCR采集样本的标准和标准操作程序（SOP）;严格的QAQC协议;用于全面的总RNA，mRNA和miRNA测序的先进方法，自动化和技术;尖端的生物信息学评估;以及与NCI数据库合作的丰富经验。随着新的基因组技术的出现，基因组研究所已经做好了充分的准备来研究、评估和实施新的基因组技术。最后，我们拥有超过15年的癌症相关样本转录表征的广泛记录。