CHIASMA: Accessible Innovative Methods for the Safety & Sustainability Assessment of Chemicals & Materials

CHIASMA的中心目标是开发一个新的和改进的安全和可持续的设计评估框架，该框架基于创新的、项目内验证的体外和计算机模拟方法新方法（NAM）和数据，用于下一代化学品和材料的危害和风险评估。已制定的适合本国的监测方案涵盖主要的人体目标器官和接触途径。CHIASMA评估框架将基于下一代安全性评估（NGSA）的迭代多步法，该方法结合了化学中心和生物中心方法以及NAMs，并且能够预测监管相关终点和长期安全性，以及绝对生命周期影响分析（LCIA）。在提交给监管机构之前，将证明开发的方法的科学合理性和性能以及可转移性（包括工业环境）。至少在三个化学品/材料类别（PFAS、用于能源应用的二维材料和（纳米）农药）中展示SSbD框架，并在现有方法背景下对社会经济方面进行评估和差距分析。将新的和改进的安全和健康参数表达方法整合到现有的生命周期和可持续性评估方法和工具中，以及相关的适用监管框架中（包括SSbD框架）。为行业和公共当局提供可访问的数据，以最终支持SSbD框架及其标准的更广泛实施。CHIASMA项目将持续48个月。它是有组织的相互依赖的工作流程，将被分解为9个与科学计划相一致的工作包，以提供最佳的项目实施和项目目标的实现。

The CHIASMA’s Central Objective is to develop a new and improved Safety and Sustainable by Design Assessment framework based on innovative, in-project validated in vitro and in silico methods New Approach Methodologies (NAMs) and data for the next generation of hazard- & risk assessment of chemicals and materials. The developed NAMs cover main human target organs and exposure routes. The CHIASMA Assessment Framework will be based on an iterative multi-step approach based on Next Genaration Safety Assessment (NGSA) that combines chemocentric and biocentric approaches and NAMs and it will be able to predict regulatory relevant endpoints and long-term safety, together with absolute Life Cycle Impact Analysis (LCIA). Developed methods will be demonstrated for scienfic soundness and performances and for transferability (including to industrial environment), prior to submission to regulatory bodies. Demonstration of the SSbD Framework in at least three chemicals/materials groups (PFAS, 2D materials for energy applications and (nano-)pesticides), supported by the assessment of socio-economic aspects and gap analyses in the context of existing methods. Integration of the new & improved methods for expressing safety and health parameter into existing life-cycle and sustainability assessments methodologies and tools, as well as into the relevant applicable regulatory frameworks (incl. the SSbD framework). Provision of accessible data for industry and public authorities, in order to ultimately support the wider implementation of the SSbD framework and its criteria. The CHIASMA Project will run for 48 months. It is organised interdependent workflows, which will be broken down into 9 workpackages aligned with the scientific plan in order provide an optimum project-conduct and achievement of Project objectives.