CHIASMA: Accessible Innovative Methods for the Safety & Sustainability Assessment of Chemicals & Materials

CHIASMA 的中心目标是开发一个新的、改进的安全和可持续设计评估框架，该框架基于创新的、项目内验证的体外和计算机方法新方法 (NAM) 和数据，用于下一代化学品和材料的危害和风险评估。开发的NAMs涵盖了主要的人体靶器官和暴露途径。 CHIASMA 评估框架将基于下一代安全评估 (NGSA) 的迭代多步骤方法，该方法结合了化学中心和生物中心方法以及 NAM，它将能够预测监管相关终点和长期安全性，以及绝对生命周期影响分析 (LCIA)。在提交给监管机构之前，将验证开发的方法的科学合理性和性能以及可转移性（包括工业环境）。在至少三个化学品/材料组（PFAS、用于能源应用的二维材料和（纳米）农药）中展示 SSbD 框架，并在现有方法的背景下进行社会经济方面的评估和差距分析。将用于表达安全和健康参数的新的和改进的方法整合到现有的生命周期和可持续性评估方法和工具中，以及相关的适用监管框架（包括 SSbD 框架）中。为行业和公共当局提供可访问的数据，以最终支持 SSbD 框架及其标准的更广泛实施。 CHIASMA 项目将运行 48 个月。它由相互依赖的工作流程组成，将分为 9 个与科学计划相一致的工作包，以便提供最佳的项目实施和项目目标的实现。

The CHIASMA’s Central Objective is to develop a new and improved Safety and Sustainable by Design Assessment framework based on innovative, in-project validated in vitro and in silico methods New Approach Methodologies (NAMs) and data for the next generation of hazard- & risk assessment of chemicals and materials. The developed NAMs cover main human target organs and exposure routes. The CHIASMA Assessment Framework will be based on an iterative multi-step approach based on Next Genaration Safety Assessment (NGSA) that combines chemocentric and biocentric approaches and NAMs and it will be able to predict regulatory relevant endpoints and long-term safety, together with absolute Life Cycle Impact Analysis (LCIA). Developed methods will be demonstrated for scienfic soundness and performances and for transferability (including to industrial environment), prior to submission to regulatory bodies. Demonstration of the SSbD Framework in at least three chemicals/materials groups (PFAS, 2D materials for energy applications and (nano-)pesticides), supported by the assessment of socio-economic aspects and gap analyses in the context of existing methods. Integration of the new & improved methods for expressing safety and health parameter into existing life-cycle and sustainability assessments methodologies and tools, as well as into the relevant applicable regulatory frameworks (incl. the SSbD framework). Provision of accessible data for industry and public authorities, in order to ultimately support the wider implementation of the SSbD framework and its criteria. The CHIASMA Project will run for 48 months. It is organised interdependent workflows, which will be broken down into 9 workpackages aligned with the scientific plan in order provide an optimum project-conduct and achievement of Project objectives.