CHIASMA: Accessible Innovative Methods for the Safety & Sustainability Assessment of Chemicals & Materials

CHIASMA：可获取的安全创新方法

• 批准号: 10101594
• 金额: $ 45.07万
• 依托单位: UNIVERSITY OF BIRMINGHAM
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10101594
• 关键词: CHIASMA; Accessible; Innovative; Methods; Safety

The CHIASMA’s Central Objective is to develop a new and improved Safety and Sustainable by Design Assessment framework based on innovative, in-project validated in vitro and in silico methods New Approach Methodologies (NAMs) and data for the next generation of hazard- & risk assessment of chemicals and materials. The developed NAMs cover main human target organs and exposure routes. The CHIASMA Assessment Framework will be based on an iterative multi-step approach based on Next Genaration Safety Assessment (NGSA) that combines chemocentric and biocentric approaches and NAMs and it will be able to predict regulatory relevant endpoints and long-term safety, together with absolute Life Cycle Impact Analysis (LCIA). Developed methods will be demonstrated for scienfic soundness and performances and for transferability (including to industrial environment), prior to submission to regulatory bodies. Demonstration of the SSbD Framework in at least three chemicals/materials groups (PFAS, 2D materials for energy applications and (nano-)pesticides), supported by the assessment of socio-economic aspects and gap analyses in the context of existing methods. Integration of the new & improved methods for expressing safety and health parameter into existing life-cycle and sustainability assessments methodologies and tools, as well as into the relevant applicable regulatory frameworks (incl. the SSbD framework). Provision of accessible data for industry and public authorities, in order to ultimately support the wider implementation of the SSbD framework and its criteria. The CHIASMA Project will run for 48 months. It is organised interdependent workflows, which will be broken down into 9 workpackages aligned with the scientific plan in order provide an optimum project-conduct and achievement of Project objectives.

这种偏心的目标是通过基于创新的，项目验证的体外和硅方法验证的新方法（NAMS）和下一代危害和风险评估化学物质和材料的危险和风险评估的数据，通过设计评估框架开发新的且可持续的新安全和可持续性。开发的NAM涵盖了主要的人类目标器官和暴露路线。阶段评估框架将基于基于下一代安全评估（NGSA）的迭代多步骤方法，该方法结合了化学中心和生物为中心的方法和NAM，它将能够预测监管相关的终点和长期安全性以及绝对生命周期影响分析（LCIA）。在提交监管机构之前，将证明开发的方法以科学的健全性和性能以及可转让性（包括工业环境）（包括工业环境）。在现有方法中评估社会经济方面和间隙分析的支持下，至少三个化学药品/材料组（PFAS，2D材料和（纳米）农药的2D材料）中的SSBD框架的演示。将新的和改进的方法集成到现有的生命周期和可持续性评估方法和工具以及相关适用的监管框架（包括SSBD框架）中。为行业和公共当局提供可访问的数据，以最终支持SSBD框架及其标准的更广泛实施。 Chiasma项目将运行48个月。它是有组织的相互依存工作流，将分解为与科学计划一致的9个工作包，以便为项目目标提供最佳的项目指导和实现。