Accessible Innovative Methods for the Safety and Sustainability Assessment of Chemicals and Materials
化学品和材料安全性和可持续性评估的可用创新方法
基本信息
- 批准号:10097666
- 负责人:
- 金额:$ 51.85万
- 依托单位:
- 依托单位国家:英国
- 项目类别:EU-Funded
- 财政年份:2024
- 资助国家:英国
- 起止时间:2024 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The CHIASMA’s Central Objective is to develop a new and improved Safety and Sustainable by Design Assessment frameworkbased on innovative, in-project validated in vitro and in silico methods New Approach Methodologies (NAMs) and data for the nextgeneration of hazard- & risk assessment of chemicals and materials. The developed NAMs cover main human target organs and exposureroutes. The CHIASMA Assessment Framework will be based on an iterative multi-step approach based on Next Genaration SafetyAssessment (NGSA) that combines chemocentric and biocentric approaches and NAMs and it will be able to predict regulatory relevantendpoints and long-term safety, together with absolute Life Cycle Impact Analysis (LCIA). Developed methods will be demonstratedfor scienfic soundness and performances and for transferability (including to industrial environment), prior to submission to regulatorybodies. Demonstration of the SSbD Framework in at least three chemicals/materials groups (PFAS, 2D materials for energy applicationsand (nano-)pesticides), supported by the assessment of socio-economic aspects and gap analyses in the context of existing methods.Integration of the new & improved methods for expressing safety and health parameter into existing life-cycle and sustainabilityassessments methodologies and tools, as well as into the relevant applicable regulatory frameworks (incl. the SSbD framework). Provisionof accessible data for industry and public authorities, in order to ultimately support the wider implementation of the SSbD frameworkand its criteria. The CHIASMA Project will run for 48 months. It is organised interdependent workflows, which will be broken downinto 9 workpackages aligned with the scientific plan in order provide an optimum project-conduct and achievement of Project objectives.
CHIASMA的中心目标是开发一个新的和改进的安全和可持续的设计评估框架,该框架基于创新的、项目内验证的体外和计算机方法新方法(NAM)和数据,用于下一代化学品和材料的危害和风险评估。已开发的NAM涵盖主要的人体靶器官和靶向途径。CHIASMA评估框架将基于下一代安全评估(NGSA)的迭代多步骤方法,该方法结合了化学中心和生物中心方法以及NAMs,并且能够预测监管相关点和长期安全性,以及绝对生命周期影响分析(LCIA)。在提交给监管机构之前,将对开发的方法的科学合理性和性能以及可转移性(包括工业环境)进行论证。在至少三个化学品/材料类别中展示SSbD框架(PFAS,用于能源应用和(纳米)农药的二维材料),并在现有方法的背景下进行社会经济方面的评估和差距分析,将新的和改进的安全和健康参数表达方法纳入现有的生命周期和可持续性评估方法和工具,以及相关适用的监管框架(包括,SSbD框架)。为行业和公共当局提供可访问的数据,以最终支持SSbD框架及其标准的更广泛实施。CHIASMA项目将持续48个月。它是有组织的相互依赖的工作流程,将被分解为9个与科学计划相一致的工作包,以提供最佳的项目实施和项目目标的实现。
项目成果
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其他文献
吉治仁志 他: "トランスジェニックマウスによるTIMP-1の線維化促進機序"最新医学. 55. 1781-1787 (2000)
Hitoshi Yoshiji 等:“转基因小鼠中 TIMP-1 的促纤维化机制”现代医学 55. 1781-1787 (2000)。
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LiDAR Implementations for Autonomous Vehicle Applications
- DOI:
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2021 - 期刊:
- 影响因子:0
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吉治仁志 他: "イラスト医学&サイエンスシリーズ血管の分子医学"羊土社(渋谷正史編). 125 (2000)
Hitoshi Yoshiji 等人:“血管医学与科学系列分子医学图解”Yodosha(涉谷正志编辑)125(2000)。
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Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)
钙拮抗剂盐酸马尼地平对异丙肾上腺素引起的左心室肥厚的影响:“Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,
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