Accessible Innovative Methods for the Safety and Sustainability Assessment of Chemicals and Materials

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The CHIASMA’s Central Objective is to develop a new and improved Safety and Sustainable by Design Assessment frameworkbased on innovative, in-project validated in vitro and in silico methods New Approach Methodologies (NAMs) and data for the nextgeneration of hazard- & risk assessment of chemicals and materials. The developed NAMs cover main human target organs and exposureroutes. The CHIASMA Assessment Framework will be based on an iterative multi-step approach based on Next Genaration SafetyAssessment (NGSA) that combines chemocentric and biocentric approaches and NAMs and it will be able to predict regulatory relevantendpoints and long-term safety, together with absolute Life Cycle Impact Analysis (LCIA). Developed methods will be demonstratedfor scienfic soundness and performances and for transferability (including to industrial environment), prior to submission to regulatorybodies. Demonstration of the SSbD Framework in at least three chemicals/materials groups (PFAS, 2D materials for energy applicationsand (nano-)pesticides), supported by the assessment of socio-economic aspects and gap analyses in the context of existing methods.Integration of the new & improved methods for expressing safety and health parameter into existing life-cycle and sustainabilityassessments methodologies and tools, as well as into the relevant applicable regulatory frameworks (incl. the SSbD framework). Provisionof accessible data for industry and public authorities, in order to ultimately support the wider implementation of the SSbD frameworkand its criteria. The CHIASMA Project will run for 48 months. It is organised interdependent workflows, which will be broken downinto 9 workpackages aligned with the scientific plan in order provide an optimum project-conduct and achievement of Project objectives.