The 10,000 Families Cohort: a new study to understand the environmental causes of cancer

万个家庭队列：一项了解癌症环境原因的新研究

• 批准号: 10494289
• 负责人: HEATHER Hammond NELSON
• 金额: $ 103.62万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10494289
• 关键词: Address; Adult; Advocacy; Age; Agriculture; Air; Ancillary Study; Automobile Driving; Biological Markers; Blood; Cancer Center; Cancer Etiology; Carcinogens; Cells; Chemicals; Child; Cohort Studies; Collection; Communities; Community Outreach; County; Data; Development; Dysmyelopoietic Syndromes; Education and Outreach; Environmental Exposure; Epigenetic Process; Exposure to; Family; Family Study; Fingers; Funding; Gold; Hair; Hematologic Agents; Hematologic Neoplasms; Hematology; Hematopoiesis; Heme; Heritability; High Prevalence; Hispanic; Household; Human; Immigrant; Immigrant community; Immune; Immunity; Immunologic Markers; Incidence; Individual; International Agency for Research on Cancer; Iowa; Link; Longterm Follow-up; Malignant Neoplasms; Measures; Methodology; Methods; Minnesota; Non-Hodgkin' s Lymphoma; Outcome; Participant; Patient Recruitments; Pesticides; Phase; Poly-fluoroalkyl substances; Population; Prevalence; Prospective cohort; Radon; Recording of previous events; Reporting; Research; Research Institute; Risk; Risk Factors; Role; Roundup; Rural; Rural Community; Serum; Silicon; Silicones; System; Technology; Testing; Time; Underrepresented Populations; Universities; Urine; Venous; Water; Wisconsin; base; biobank; cancer risk; cancer type; carcinogenicity; cohort; community engagement; de novo mutation; early detection biomarkers; empowerment; epigenomics; ethnic minority; geographic difference; glyphosate; high risk; innovation; interest; leukemia; leukemia/lymphoma; microbiome; neoplasm registry; pilot test; racial and ethnic; recruit; residence; rural area; study population; urban area; virtual

Abstract The 10,000 Families Study (10KFS) will be a new, family-based cohort study in Minnesota, the ‘Land of 10,000 Lakes’. Due to our high incidence rates of hematologic malignancy (leukemia, lymphoma, and myelodysplastic syndromes), we will focus our proposal on environmental exposures of concern that are possible hematologic carcinogens with limited evidence in humans as defined by the International Agency for Research on Cancer (IARC). This includes glyphosate, poly- and perfluoroalkyl substances (PFAS), and radon, all of which have well-described geographic variation in prevalence in the state of Minnesota. During the UG3 phase, we will evaluate innovative exposure assessment methodologies and recruit diverse participants into the 10KFS cohort. Exposure assessment will include residential history, ambient measures in air and water at current residence, as well as individual-level exposure assessed with silicone wearable bracelets, serum, hair, and urine. Participants will be recruited from targeted counties that maximize the exposure distribution to our three carcinogens of interest and include under-represented populations from rural and immigrant communities. We will measure clonal hematopoiesis of indeterminate potential (CHIP), a precursor to heme malignancy, and perturbations in immunity and epigenetics as our primary cancer-related outcomes in the UH3 phase. Our target is to recruit 8,750 participants from 4,000 households to participate using recruitment strategies that have been developed and pilot tested. Our central hypothesis is that PFAS, glyphosate and radon contribute to increased hematologic malignancy specifically, and cancer incidence broadly, in Minnesota. Cancer incidence will be determined via annual record linkage with the Minnesota Cancer Reporting System (MCRS) and the Virtual Pooled Registry Cancer Linkage System. The scientific aims in the UG3 phase will be to: 1) evaluate innovative exposure assessment methods for PFAS and glyphosate that can be easily implemented in a large scale study and 2) describe the exposure burden in under-represented immigrant populations. We will complete recruitment of the study population in the UH3 phase where the specific aims are to: 1) determine whether levels of radon, glyphosate, and PFAS are associated with increased prevalence of CHIP and 2) utilize epigenomics to test the hypotheses that radon, glyphosate and PFAS exposure are associated with immune dysregulation and epigenetic signatures. Our community engagement will be conducted in partnership with the non-profit research institute Hispanic Advocacy and Community Empowerment Through Research (HACER), the Minnesota Freemasons and Order of the Eastern Star and community educators from the Extension Center for Family Development. The results of this study will provide needed data to inform whether these agents are hematologic carcinogens, it will address documented disparities in exposure that occur within our state and provide a mechanism for community outreach and education concerning these exposures and any potential cancer link.

抽象的 10,000个家庭研究（10kFs）将是明尼苏达州的一项新的，基于家庭的队列研究，是10,000的土地 湖泊。由于我们的血液系统恶性肿瘤发病率很高（白血病，淋巴瘤和骨髓增生 综合症），我们将把建议重点放在可能血液学的关注环境暴露上 国际癌症研究机构定义的人类证据有限的致癌物 （IARC）。这包括糖糖，多氟烷基物质（PFA）和ra，所有这些都有 明尼苏达州状况良好描述的地理差异。在UG3阶段，我们将 评估创新的曝光评估方法，并将潜水员参与者招募到10kFs 队列。接触评估将包括居民历史，当前空气中的环境措施和水的环境措施 居住以及用硅胶可穿戴手镯，血清，头发和 尿。参与者将从目标县招募，这些县将暴露分布最大化到我们的三个 感兴趣的致癌物包括来自粗糙和移民社区的代表性不足的人群。我们 将测量不确定电势的克隆造血（芯片），是血红素恶性肿瘤的前体， 免疫和表观遗传学的扰动是我们在UH3期与癌症相关的主要结果。我们的 目标是招募来自4,000户家庭的8,750名参与者，以使用招聘策略参加 已经开发并进行了试点测试。我们的核心假设是PFA，糖酸盐和ra有助于 明尼苏达州的血液系统恶性肿瘤和癌症发病率很大。癌症发病率 将通过与明尼苏达州癌症报告系统（MCR）和 虚拟合并注册表癌连接系统。在UG3阶段的科学目的是：1）评估 PFA和糖酸盐的创新暴露评估方法可以轻松地在大型中实施 比例研究和2）描述代表性不足的移民人群中的暴露燃烧。我们将 在UH3阶段进行研究人群的完整招募，该阶段的特定目的是：1）确定 ra，糖酸盐和PFA的水平是否与芯片的患病率增加有关，2） 利用表观基因组学来检验ra，糖磷酸盐和PFAS暴露有关的假设 免疫失调和表观遗传特征。我们的社区参与将与 通过非营利研究所西班牙裔倡导和社区授权通过研究 （HACER），明尼苏达州的共济会和东方之星的秩序和社区教育工作者 家庭发展扩展中心。这项研究的结果将提供所需的数据，以告知是否是否 这些药物是血液学致癌物，它将解决发生在 我们的国家，为这些暴露和教育提供了一种机制 任何潜在的癌症联系。