The 10,000 Families Cohort: a new study to understand the environmental causes of cancer

万个家庭队列：一项了解癌症环境原因的新研究

• 批准号: 10900881
• 负责人: HEATHER Hammond NELSON
• 金额: $ 268.02万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10900881
• 关键词: Acceleration; Address; Adult; Advocacy; Age; Agriculture; Air; Ancillary Study; Automobile Driving; Biological Markers; Blood; Cancer Center; Cancer Etiology; Carcinogens; Cells; Chemicals; Child; Classification; Cohort Studies; Collection; Communities; Community Health Education; Community Outreach; County; Data; Development; Disparity; Dysmyelopoietic Syndromes; Environmental Exposure; Epigenetic Process; Ethnic Population; Exposure to; Family; Family Study; Fingers; Funding; Gold; Hair; Hematologic Agents; Hematologic Neoplasms; Hematology; Hematopoiesis; Heme; Heritability; High Prevalence; Hispanic; Household; Human; Immigrant; Immigrant community; Immune; Immunity; Immunologic Markers; Incidence; Individual; International Agency for Research on Cancer; Iowa; Link; Longterm Follow-up; Lymphoma; Malignant Neoplasms; Measures; Methodology; Methods; Minnesota; Non-Hodgkin' s Lymphoma; Outcome; Participant; Patient Recruitments; Pesticides; Phase; Poly-fluoroalkyl substances; Population; Prevalence; Prospective cohort; Radon; Recording of previous events; Reporting; Research; Research Institute; Risk; Risk Factors; Role; Roundup; Rural; Rural Community; Serum; Silicon; Silicones; System; Technology; Testing; Time; Underrepresented Populations; Universities; Urine; Venous; Water; Wisconsin; biobank; cancer risk; cancer type; carcinogenicity; cohort; community engagement; de novo mutation; early detection biomarkers; empowerment; epigenomics; ethnic minority; geographic difference; glyphosate; high risk; innovation; interest; leukemia; manufacture; microbiome; neoplasm registry; pilot test; racial minority; racial population; recruit; residence; rural area; study population; urban area; virtual

Abstract The 10,000 Families Study (10KFS) will be a new, family-based cohort study in Minnesota, the ‘Land of 10,000 Lakes’. Due to our high incidence rates of hematologic malignancy (leukemia, lymphoma, and myelodysplastic syndromes), we will focus our proposal on environmental exposures of concern that are possible hematologic carcinogens with limited evidence in humans as defined by the International Agency for Research on Cancer (IARC). This includes glyphosate, poly- and perfluoroalkyl substances (PFAS), and radon, all of which have well-described geographic variation in prevalence in the state of Minnesota. During the UG3 phase, we will evaluate innovative exposure assessment methodologies and recruit diverse participants into the 10KFS cohort. Exposure assessment will include residential history, ambient measures in air and water at current residence, as well as individual-level exposure assessed with silicone wearable bracelets, serum, hair, and urine. Participants will be recruited from targeted counties that maximize the exposure distribution to our three carcinogens of interest and include under-represented populations from rural and immigrant communities. We will measure clonal hematopoiesis of indeterminate potential (CHIP), a precursor to heme malignancy, and perturbations in immunity and epigenetics as our primary cancer-related outcomes in the UH3 phase. Our target is to recruit 8,750 participants from 4,000 households to participate using recruitment strategies that have been developed and pilot tested. Our central hypothesis is that PFAS, glyphosate and radon contribute to increased hematologic malignancy specifically, and cancer incidence broadly, in Minnesota. Cancer incidence will be determined via annual record linkage with the Minnesota Cancer Reporting System (MCRS) and the Virtual Pooled Registry Cancer Linkage System. The scientific aims in the UG3 phase will be to: 1) evaluate innovative exposure assessment methods for PFAS and glyphosate that can be easily implemented in a large scale study and 2) describe the exposure burden in under-represented immigrant populations. We will complete recruitment of the study population in the UH3 phase where the specific aims are to: 1) determine whether levels of radon, glyphosate, and PFAS are associated with increased prevalence of CHIP and 2) utilize epigenomics to test the hypotheses that radon, glyphosate and PFAS exposure are associated with immune dysregulation and epigenetic signatures. Our community engagement will be conducted in partnership with the non-profit research institute Hispanic Advocacy and Community Empowerment Through Research (HACER), the Minnesota Freemasons and Order of the Eastern Star and community educators from the Extension Center for Family Development. The results of this study will provide needed data to inform whether these agents are hematologic carcinogens, it will address documented disparities in exposure that occur within our state and provide a mechanism for community outreach and education concerning these exposures and any potential cancer link.

摘要 10，000个家庭研究（10KFS）将是在“万人之地”明尼苏达州进行的一项新的、以家庭为基础的队列研究 莱克斯的由于我们血液系统恶性肿瘤（白血病、淋巴瘤和骨髓增生异常）的高发病率， 综合征），我们将把我们的建议集中在环境暴露的关注，可能是血液病 国际癌症研究机构定义的对人类影响证据有限的致癌物 （IARC）。这包括草甘膦，聚和全氟烷基物质（PFAS）和氡，所有这些都具有 明尼苏达州的流行率存在明显的地理差异。在UG3阶段， 评估创新的暴露评估方法，并招募不同的参与者参加10个KFS 队列。暴露评估将包括居住历史、当前空气和水中的环境测量值 居住，以及个人水平的暴露评估与硅胶可穿戴手镯，血清，头发， 尿参与者将从目标县招募，这些县最大限度地扩大了我们三个县的暴露分布。 致癌物的利益，包括代表性不足的人口从农村和移民社区。我们 将测量不确定潜能的克隆造血（CHIP），这是血红素恶性肿瘤的前兆， 免疫和表观遗传学的扰动是我们在UH3期的主要癌症相关结局。我们 目标是从4 000个家庭招募8 750名参与者， 已经开发和试点测试。我们的中心假设是PFAS，草甘膦和氡有助于 在明尼苏达州，血液恶性肿瘤的发病率和癌症的发病率增加。癌症发病率 将通过与明尼苏达州癌症报告系统（MCRS）和 虚拟合并登记癌症连锁系统。UG3阶段的科学目标是：1）评估 PFAS和草甘膦的创新性暴露评估方法，可以在大范围内轻松实施， 规模研究和2）描述代表性不足的移民人口的暴露负担。我们将 在UH3阶段完成研究人群的招募，具体目的是：1）确定 氡、草甘膦和PFAS水平是否与CHIP患病率增加有关，以及2） 利用表观基因组学来检验氡、草甘膦和PFAS暴露与 免疫失调和表观遗传特征。我们的社区参与将通过伙伴关系进行 与非营利研究机构西班牙裔倡导和社区赋权通过研究 （HACER），明尼苏达共济会和东方之星星星和社区教育工作者从 家庭发展推广中心。这项研究的结果将提供所需的数据，以告知是否 这些物质是血液学致癌物，它将解决记录的差异暴露发生在 我们的国家，并提供一个机制，社区外展和教育有关这些风险， 任何潜在的癌症联系