The 10,000 Families Cohort: a new study to understand the environmental causes of cancer

万个家庭队列：一项了解癌症环境原因的新研究

• 批准号: 10900881
• 负责人: HEATHER Hammond NELSON
• 金额: $ 268.02万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10900881
• 关键词: Acceleration; Address; Adult; Advocacy; Age; Agriculture; Air; Ancillary Study; Automobile Driving; Biological Markers; Blood; Cancer Center; Cancer Etiology; Carcinogens; Cells; Chemicals; Child; Classification; Cohort Studies; Collection; Communities; Community Health Education; Community Outreach; County; Data; Development; Disparity; Dysmyelopoietic Syndromes; Environmental Exposure; Epigenetic Process; Ethnic Population; Exposure to; Family; Family Study; Fingers; Funding; Gold; Hair; Hematologic Agents; Hematologic Neoplasms; Hematology; Hematopoiesis; Heme; Heritability; High Prevalence; Hispanic; Household; Human; Immigrant; Immigrant community; Immune; Immunity; Immunologic Markers; Incidence; Individual; International Agency for Research on Cancer; Iowa; Link; Longterm Follow-up; Lymphoma; Malignant Neoplasms; Measures; Methodology; Methods; Minnesota; Non-Hodgkin' s Lymphoma; Outcome; Participant; Patient Recruitments; Pesticides; Phase; Poly-fluoroalkyl substances; Population; Prevalence; Prospective cohort; Radon; Recording of previous events; Reporting; Research; Research Institute; Risk; Risk Factors; Role; Roundup; Rural; Rural Community; Serum; Silicon; Silicones; System; Technology; Testing; Time; Underrepresented Populations; Universities; Urine; Venous; Water; Wisconsin; biobank; cancer risk; cancer type; carcinogenicity; cohort; community engagement; de novo mutation; early detection biomarkers; empowerment; epigenomics; ethnic minority; geographic difference; glyphosate; high risk; innovation; interest; leukemia; manufacture; microbiome; neoplasm registry; pilot test; racial minority; racial population; recruit; residence; rural area; study population; urban area; virtual

Abstract The 10,000 Families Study (10KFS) will be a new, family-based cohort study in Minnesota, the ‘Land of 10,000 Lakes’. Due to our high incidence rates of hematologic malignancy (leukemia, lymphoma, and myelodysplastic syndromes), we will focus our proposal on environmental exposures of concern that are possible hematologic carcinogens with limited evidence in humans as defined by the International Agency for Research on Cancer (IARC). This includes glyphosate, poly- and perfluoroalkyl substances (PFAS), and radon, all of which have well-described geographic variation in prevalence in the state of Minnesota. During the UG3 phase, we will evaluate innovative exposure assessment methodologies and recruit diverse participants into the 10KFS cohort. Exposure assessment will include residential history, ambient measures in air and water at current residence, as well as individual-level exposure assessed with silicone wearable bracelets, serum, hair, and urine. Participants will be recruited from targeted counties that maximize the exposure distribution to our three carcinogens of interest and include under-represented populations from rural and immigrant communities. We will measure clonal hematopoiesis of indeterminate potential (CHIP), a precursor to heme malignancy, and perturbations in immunity and epigenetics as our primary cancer-related outcomes in the UH3 phase. Our target is to recruit 8,750 participants from 4,000 households to participate using recruitment strategies that have been developed and pilot tested. Our central hypothesis is that PFAS, glyphosate and radon contribute to increased hematologic malignancy specifically, and cancer incidence broadly, in Minnesota. Cancer incidence will be determined via annual record linkage with the Minnesota Cancer Reporting System (MCRS) and the Virtual Pooled Registry Cancer Linkage System. The scientific aims in the UG3 phase will be to: 1) evaluate innovative exposure assessment methods for PFAS and glyphosate that can be easily implemented in a large scale study and 2) describe the exposure burden in under-represented immigrant populations. We will complete recruitment of the study population in the UH3 phase where the specific aims are to: 1) determine whether levels of radon, glyphosate, and PFAS are associated with increased prevalence of CHIP and 2) utilize epigenomics to test the hypotheses that radon, glyphosate and PFAS exposure are associated with immune dysregulation and epigenetic signatures. Our community engagement will be conducted in partnership with the non-profit research institute Hispanic Advocacy and Community Empowerment Through Research (HACER), the Minnesota Freemasons and Order of the Eastern Star and community educators from the Extension Center for Family Development. The results of this study will provide needed data to inform whether these agents are hematologic carcinogens, it will address documented disparities in exposure that occur within our state and provide a mechanism for community outreach and education concerning these exposures and any potential cancer link.

抽象的 10,000 个家庭研究 (10KFS) 将是一项新的、以家庭为基础的队列研究，在明尼苏达州这个“10,000 人的土地” 湖’。由于我国血液系统恶性肿瘤（白血病、淋巴瘤、骨髓增生异常等）发病率较高， 综合征），我们将把我们的提案重点放在可能引起血液学问题的环境暴露上 国际癌症研究机构定义的人类致癌物的证据有限 （国际癌症研究机构）。这包括草甘膦、多氟烷基物质和全氟烷基物质 (PFAS) 以及氡，所有这些物质都具有 详细描述了明尼苏达州患病率的地理差异。在UG3阶段，我们将 评估创新的暴露评估方法并招募不同的参与者加入 10KFS 队列。暴露评估将包括居住史、当前空气和水中的环境措施 居住地以及使用硅胶可穿戴手环、血清、头发和 尿。参与者将从目标县招募，最大限度地扩大我们三个的曝光分布 感兴趣的致癌物，包括来自农村和移民社区的代表性不足的人群。我们 将测量不确定潜力的克隆造血（CHIP），这是血红素恶性肿瘤的前兆，并且 免疫和表观遗传学的扰动是 UH3 阶段与癌症相关的主要结果。我们的 目标是招募来自 4,000 个家庭的 8,750 名参与者参与，采用的招募策略 已经开发并进行了试点测试。我们的中心假设是 PFAS、草甘膦和氡有助于 在明尼苏达州，血液恶性肿瘤的发病率尤其增加，癌症的发病率也普遍增加。癌症发病率 将通过与明尼苏达州癌症报告系统 (MCRS) 和 虚拟汇集登记癌症关联系统。 UG3 阶段的科学目标是： 1) 评估 PFAS 和草甘膦的创新暴露评估方法，可轻松在大范围内实施 规模研究和 2) 描述了代表性不足的移民群体的暴露负担。我们将 在 UH3 阶段完成研究人群的招募，其具体目标是： 1) 确定 氡气、草甘膦和 PFAS 的水平是否与 CHIP 患病率增加有关；2) 利用表观基因组学来检验氡气、草甘膦和 PFAS 暴露与相关的假设 免疫失调和表观遗传特征。我们的社区参与将通过合作伙伴关系进行 与非营利性研究机构“西班牙裔倡导和社区赋权研究”合作 (HACER)、明尼苏达共济会和东方之星勋章以及来自 家庭发展推广中心。这项研究的结果将提供所需的数据来告知是否 这些物质是血液致癌物，它将解决记录在案的暴露差异 我们的州并提供有关这些暴露的社区外展和教育机制 任何潜在的癌症联系。