Mass Spectrometric Analytical Collaborations with Members of the Carcinogenesis and Chemoprevention Program of the University of Minnesota Masonic Cancer Center

项目摘要 我是明尼苏达大学共济会癌症中心分析生物化学共享资源的主任 (MCC)是美国国家癌症研究所指定的综合癌症中心。共享资源已经成为一种 领先的学术质谱实验室，作为MCC致癌和化学预防的延伸 计划（CCP），并为占分析大多数的CCP成员提供关键分析服务 在设施中进行。目前有16个国家癌症研究所资助的项目，涉及9名中共党员，他们利用群众 光谱测定设备分析生物化学共享资源和CCP的整合是这样的， 光谱实验室工作人员，通过广泛的培训和咨询小组成员和合作， 主要调查员，作为许多研究小组的分析组成部分。科学的目标， CCP旨在了解致癌的化学和分子机制。这些知识的相关性 公共卫生是通过使用它来开发和评估预防癌症的实用方法的能力。 我是中国共产党的一个组成部分，通过广泛的咨询和合作，与成员就其质量 光谱分析，以及与他们的研究小组密切合作。我每天都和 研究人员和常规参加实验室小组会议，帮助撰写手稿，并参加 CCP研讨会系列和翻译生物标志物工作组。需要我的咨询和合作 与中共成员就先进的分析测量，以及日常的培训和监督 随着实验室分析能力的提高， 以及用户越来越依赖质谱分析来推进他们的研究。持续需要 继续推进该设施的分析能力，因为生物医学质谱领域继续 成长和项目成员的研究目标的演变。一个外部的财政支持来源会给我 独立和自由，专注于与NCI资助的CCP成员合作，为他们提供 指导和知识，以利用质谱实验室的先进分析能力。

Project Summary I am the Director of the Analytical Biochemistry Shared Resource of the University of Minnesota's Masonic Cancer Center (MCC), a National Cancer Institute-designated Comprehensive Cancer Center. The shared resource has emerged as a leading academic mass spectrometry laboratory, acting as an extension of the MCC's Carcinogenesis and Chemoprevention Program (CCP), and providing critical analytical services to CCP members who account for a large majority of the analysis performed in the facility. There are currently 16 NCI-funded projects involving nine CCP members who use the mass spectrometry facility. The integration of the Analytical Biochemistry Shared Resource and the CCP is such that the mass spectrometry laboratory staff, through extensive training and consultation with group members and collaboration with principal investigators, functions as the analytical component of many of the research groups. The scientific goals of the CCP are to understand the chemical and molecular mechanisms of carcinogenesis. The relevance of this knowledge to public health is through the ability to use it to develop and evaluate practical methods for cancer prevention. I am an integral part of the CCP through extensive consultation and collaboration with the members regarding their mass spectrometry-based analyses, as well as by working very closely with their research groups. I have daily interactions with the investigators and routinely attend laboratory group meetings, contribute to writing manuscripts, and participate in the CCP Seminar Series and the Translational Biomarkers Working Group. The need for my consultation and collaboration with members of the CCP regarding advanced analytical measurement, as well as day-to-day training and oversight of members of their research groups, has been growing steadily with the increasing analytical capabilities of the laboratory and increasing dependency of the users on mass spectrometric analysis to advance their research. There is an ongoing need to continue to advance the analytical capabilities of the facility as the field of biomedical mass spectrometry continues to grow and the research goals of the program members evolve. An external source of financial support would give me the independence and freedom to focus on collaborative efforts with the NCI-funded members of the CCP to provide them with the guidance and knowledge to harness the advanced analytical capabilities of the mass spectrometry laboratory.