Metabolic Dysregulation and Cancer Risk Program: Coordinating Center

项目摘要 代谢失调和癌症风险联盟（MDCRC）的目标是确定有形的 将肥胖相关的代谢失调与癌症风险联系起来的机制/病因学途径， 癌症预防策略。联合会建议通过发展共同的 测量不同癌症类型的肥胖相关代谢失调，了解肥胖- 相关代谢失调影响癌症的发生和发展，表征信号串扰 影响肥胖相关代谢失调和癌症风险的关键生物学过程之间的关系， 确定新兴方法用于发现新的肥胖相关代谢靶点的效用 癌症风险和预防。 乔治大学米尔肯研究所公共卫生学院生物统计中心 参与机构华盛顿大学（GW）提议担任MDCRC协调机构 中心（CC）。MDCRC CC将整合这些专业知识和经验，借鉴我们的成功历史 协调中心在合作研究联盟中的领导地位，创新能力，以及广泛的 肥胖和癌症预防、营养、运动、新陈代谢、身体成分方面的科学专长， 生物信息学/计算生物学形成植根于科学严谨性、灵活且反应灵敏的CC MDCRC的各种挑战和科学机遇。 MDCRC的具体目标包括：1）提供科学领导和项目管理， 协作性跨联盟活动，包括就共同措施的选择提供指导 制定一致的协议和操作手册，维护私人和公共网站， 建立专题工作组，带头开展外联活动; 2）促进数据协调， 在MDCRC各研究中心和NCI之间共享和传播结果，包括识别 新的数据收集的机会，以丰富MDCRC数据资源，开发一个共同的数据 管理平台，并对现场工作人员进行培训;以及3）建立自我评估核心，以促进及时的自我评估， 评估，沿着有效的自我纠正措施，与NCI和联盟调查人员合作， 建立与个体研究者、研究团队和联合体“成功”相关的标准和输出 网站.

PROJECT SUMMARY The goal of the Metabolic Dysregulation and Cancer Risk Consortium (MDCRC) is to identify tangible mechanistic/etiologic pathways that link obesity-related metabolic dysregulation with cancer risk to inform cancer prevention strategies. The Consortium proposes to accomplish this through developing common measures for obesity-related metabolic dysregulation for different cancer types, understanding how obesity- related metabolic dysregulation affects cancer initiation and development, characterizing signal cross-talk between key biologic processes that impact obesity-associated metabolic dysregulation and cancer risk, and determining the utility of emerging approaches for the discovery of novel obesity-associated metabolic targets in cancer risk and prevention. The Biostatistics Center (Center) in the Milken Institute School of Public Health (SPH) of the George Washington University (GW), the participating institution, proposes to serve as the MDCRC Coordinating Center (CC). The MDCRC CC will integrate this expertise and experience, drawing upon our successful history of coordinating center leadership in collaborative research consortia, capacity for innovation, and the extensive scientific expertise in obesity and cancer prevention, nutrition, exercise, metabolism, body composition, and bioinformatics/computational biology to form a CC that is rooted in scientific rigor and is flexible and responsive to the diverse challenges and scientific opportunities of the MDCRC. The specific aims of the MDCRC include to 1) provide scientific leadership and project management for collaborative cross-Consortium activities, including providing guidance on the selection of common measures and development of consistent protocols and manuals of operations, maintain private and public websites, establishing topical work groups, and spearhead outreach activities; 2) facilitate data harmonization, data sharing and results dissemination across the MDCRC sites and with NCI, including identification of opportunities for novel data collection to enrich the MDCRC data resources, developing a common data management platform, and training for site staff; and 3) establish a Self-Evaluation Core to promote timely self- evaluation, along with effective self-correcting actions, working with NCI and the Consortium investigators to establish criteria and outputs related to the “success” of individual investigators, study teams, and Consortium sites.