Metabolic Dysregulation and Cancer Risk Program: Coordinating Center

代谢失调和癌症风险计划：协调中心

• 批准号: 10502670
• 负责人: LORETTA DIPIETRO
• 金额: $ 62.52万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10502670
• 关键词: Adolescent; Affect; Agreement; Area; Bioinformatics; Biological; Biological Process; Biometry; Body Composition; Clinical Trials; Clinical Trials Data Monitoring Committees; Collaborations; Communication; Complications of Diabetes Mellitus; Computational Biology; Data; Data Analyses; Data Collection; Data Reporting; Data Set; Department chair; Development; Diabetes Mellitus; Ensure; Epidemiology; Etiology; Event; Exercise; Faculty; Fostering; Future; Goals; Grant Review; Human; Individual; Information Dissemination; Information Systems; Institutes; Institution; Intervention; Journals; Lead; Leadership; Link; Logistics; Manuals; Maternal-Fetal Medicine Units Network; Measurement; Measures; Metabolic; Metabolic Pathway; Metabolism; Methods; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome Study; Output; Pathway interactions; Pilot Projects; Plant Roots; Policies; Prevention strategy; Privatization; Protocols documentation; Public Health Schools; Recording of previous events; Reporting; Research; Research Personnel; Resources; Science; Self-Examination; Signal Transduction; Site; System; Time; Training; Universities; Washington; Work; archive data; base; cancer initiation; cancer prevention; cancer risk; cancer type; comparative effectiveness study; data archive; data harmonization; data infrastructure; data management; data repository; data resource; data sharing; design; diabetes control; diabetes prevention program; editorial; experience; flexibility; innovation; insulin secretion; meetings; member; multidisciplinary; novel; nutrition; obesity prevention; operation; outreach; programs; research study; scientific hub; skills; success; web site; working group

PROJECT SUMMARY The goal of the Metabolic Dysregulation and Cancer Risk Consortium (MDCRC) is to identify tangible mechanistic/etiologic pathways that link obesity-related metabolic dysregulation with cancer risk to inform cancer prevention strategies. The Consortium proposes to accomplish this through developing common measures for obesity-related metabolic dysregulation for different cancer types, understanding how obesity- related metabolic dysregulation affects cancer initiation and development, characterizing signal cross-talk between key biologic processes that impact obesity-associated metabolic dysregulation and cancer risk, and determining the utility of emerging approaches for the discovery of novel obesity-associated metabolic targets in cancer risk and prevention. The Biostatistics Center (Center) in the Milken Institute School of Public Health (SPH) of the George Washington University (GW), the participating institution, proposes to serve as the MDCRC Coordinating Center (CC). The MDCRC CC will integrate this expertise and experience, drawing upon our successful history of coordinating center leadership in collaborative research consortia, capacity for innovation, and the extensive scientific expertise in obesity and cancer prevention, nutrition, exercise, metabolism, body composition, and bioinformatics/computational biology to form a CC that is rooted in scientific rigor and is flexible and responsive to the diverse challenges and scientific opportunities of the MDCRC. The specific aims of the MDCRC include to 1) provide scientific leadership and project management for collaborative cross-Consortium activities, including providing guidance on the selection of common measures and development of consistent protocols and manuals of operations, maintain private and public websites, establishing topical work groups, and spearhead outreach activities; 2) facilitate data harmonization, data sharing and results dissemination across the MDCRC sites and with NCI, including identification of opportunities for novel data collection to enrich the MDCRC data resources, developing a common data management platform, and training for site staff; and 3) establish a Self-Evaluation Core to promote timely self- evaluation, along with effective self-correcting actions, working with NCI and the Consortium investigators to establish criteria and outputs related to the “success” of individual investigators, study teams, and Consortium sites.

项目总结 代谢失调和癌症风险联盟(MDCRC)的目标是确定有形的 将肥胖相关代谢失调与癌症风险联系起来的机制/病因路径 癌症预防策略。该联盟建议通过开发共同的 针对不同癌症类型的肥胖相关代谢失调的测量方法，了解肥胖是如何- 相关代谢失调影响癌症的发生和发展，表征信号串扰 在影响肥胖相关代谢失调和癌症风险的关键生物过程之间，以及 确定发现新的肥胖相关代谢靶点的新方法的效用 在癌症风险和预防方面。 乔治河米尔肯研究所公共卫生学院生物统计中心(中心) 参与机构华盛顿大学(GW)建议担任千年发展目标协调机构 中心(CC)。MDCRC CC将借鉴我们的成功历史，整合这些专门知识和经验 协调中心在合作研究联合体中的领导力、创新能力和广泛的 在肥胖和癌症预防、营养、运动、新陈代谢、身体成分和 生物信息学/计算生物学，形成植根于科学严谨、灵活和反应迅速的CC 应对千年发展目标的各种挑战和科学机遇。 MDCRC的具体目标包括1)为以下项目提供科学的领导和项目管理 跨联合体的协作活动，包括就共同措施的选择提供指导 以及制定一致的操作规程和手册，维护私人和公共网站， 建立专题工作组，并带头开展外联活动；2)促进数据统一、数据 在MDCRC站点之间和与NCI共享和传播结果，包括确定 有机会收集新的数据，以丰富千年发展目标数据资源，开发共同数据 管理平台，以及对现场员工的培训；以及3)建立自我评估核心，以促进及时的自我评估 评估，以及有效的自我纠正行动，与NCI和财团调查人员合作 建立与个人研究人员、研究团队和联盟的“成功”相关的标准和产出 网站。