Early life household air pollution, metal composition and cardiovascular health: Evidence from GRAPHS

生命早期的家庭空气污染、金属成分和心血管健康：来自图表的证据

• 批准号: 10504218
• 负责人: Darby Jack
• 金额: $ 61.87万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-07 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10504218
• 关键词: 12 year old; 4 year old; 8 year old; Accounting; Affect; Age; Air Pollution; Anthropometry; Arsenic; Biological Markers; Birth; Birth length; Blood Pressure; Body mass index; Cadmium; Carbon Monoxide; Cardiotoxicity; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Child; Childhood; Cookstove; Data; Development; Diastolic blood pressure; Environmental Exposure; Environmental Risk Factor; Exposure to; Fasting; Fire - disasters; Follow-Up Studies; Future; Gases; Ghana; Glucose; Grant; Growth; Health; Height; Heterogeneity; Hour; Household; Household Air Pollution; Infant; Intention; Intervention; Intervention Studies; Lead; Life; Life Cycle Stages; Lipids; Longitudinal Studies; Low Birth Weight Infant; Manganese; Measurement; Measures; Mediation; Metal exposure; Metals; Methods; Monitor; Morbidity - disease rate; Nickel; Outcome; Particulate Matter; Persons; Petroleum; Policies; Predisposition; Pregnancy; Pregnant Women; Prevention strategy; Public Health; Randomized; Research; Research Project Grants; Rest; Risk; Risk Estimate; Smoke; Source; Spottings; Tobacco smoke; Toxic effect; Urine; Vanadium; Weight; air monitoring; ambient air pollution; arm; attributable mortality; cardiovascular disorder risk; cardiovascular health; cohort; cooking; cost effective; cost effective intervention; data repository; disability-adjusted life years; disorder risk; evidence base; fine particles; follow-up; improved; in utero; infancy; low and middle-income countries; lung health; mortality; premature; prenatal; programs; response; treatment arm; urinary

Project summary In low- and middle-income countries ~2.8 billion people are exposed daily to smoke from cooking fires, termed household air pollution (HAP), resulting in an estimated 2.3M deaths and 91.4M DALYs in 2019. The largest proportion of HAP-attributable deaths are due to cardiovascular disease. Establishment of cardiovascular health in childhood is critical to reduce risk for future cardiovascular disease. We hypothesize that early life (prenatal to age 1) exposure to HAP alters cardiovascular development and programs future disease risk. We further hypothesize that the metal composition of air pollution drives toxicity. We propose to build on an existing pregnancy cohort in Ghana – the Ghana Randomized Air Pollution and Health Study, or GRAPHS – to assess how early life air pollution exposure and metals exposures affect cardiovascular health through age 12 years. We will use well-established, validated methods to assess these outcomes. In the long run, our research will help build the evidence base for cost effective interventions to improve health by reducing HAP exposure.

项目摘要 在低收入和中等收入国家，约有28亿人每天暴露在烹饪用火产生的烟雾中， 家庭空气污染（HAP），2019年估计导致230万人死亡和9140万人死亡。最大的 HAP导致的死亡中有一部分是由于心血管疾病。建立心血管 儿童健康对降低未来心血管疾病风险至关重要。我们假设早期生活 （产前至1岁）暴露于HAP会改变心血管发育并规划未来的疾病风险。我们 进一步假设空气污染的金属成分会导致毒性。我们建议建立一个 加纳随机空气污染和健康研究（GRAPHS） 评估生命早期空气污染暴露和金属暴露如何影响12岁以下的心血管健康 年我们将使用完善的、经过验证的方法来评估这些结果。从长远来看，我们的研究 将有助于建立具有成本效益的干预措施的证据基础，以通过减少HAP暴露来改善健康。