Child Lung Development Following a Cookstove Intervention: Evidence from GRAPHS

炉灶干预后儿童肺部发育：来自图表的证据

• 批准号: 10659800
• 负责人: Darby Jack
• 金额: $ 78.8万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10659800
• 关键词: 1 year old; 13 year old; 8 year old; Acute; Affect; Age; Air Pollution; Anthropometry; Biological; Birth; Blood; Breathing; Carbon Monoxide; Cell Line; Cells; Cessation of life; Charcoal; Child; Childhood; Chronic Disease; Chronic Obstructive Pulmonary Disease; Chronic lung disease; Cohort Studies; Cookstove; Development; Early Intervention; Effectiveness of Interventions; Epithelial Cells; Exhibits; Exposure to; Fire - disasters; Funding; Future; Gases; Gene Expression; Genetic Polymorphism; Genotype; Ghana; Glycoproteins; Growth; Health; Heterogeneity; Household; Household Air Pollution; Human; Hypertension; Impairment; Individual; Infant; Intention; Intervention; Investments; Life; Life Cycle Stages; Link; Lower Respiratory Tract Infection; Luciferases; Lung diseases; MUC5AC gene; MUC5B gene; Measures; Messenger RNA; Methods; Mucins; Mucous body substance; Mus; Mutation; Nasal Epithelium; Outcome; Outcome Assessment; Participant; Persons; Petroleum; Phenotype; Pneumonia; Policies; Predisposition; Pregnancy; Pregnant Women; Public Health; Randomized; Reporter Genes; Research; Research Project Grants; Respiratory Disease; Respiratory Signs and Symptoms; Risk; Risk Reduction; Signal Pathway; Single Nucleotide Polymorphism; Site; Smoke; Source; Spirometry; Spottings; Streptococcus pneumoniae; TP53 gene; Transfection; Variant; Wild Type Mouse; Wood material; airway epithelium; arm; attributable mortality; blood pressure reduction; cell age; cohort; comparison control; cooking; cost effective; cost effective intervention; data repository; disability-adjusted life years; disorder risk; early childhood; evidence base; fine particles; follow-up; improved; infancy; intervention effect; low and middle-income countries; lung development; lung health; lung preservation; mRNA Expression; prenatal; programs; promoter; pulmonary function; repository; response; smoke-induced lung disease; transcription factor; wood smoke

Project Summary In low- and middle-income countries ~2.8 billion people are exposed daily to smoke from cooking fires, termed household air pollution (HAP), resulting in an estimated 2.3M deaths and 91.4M DALYs in 2019. A large proportion of HAP-attributable deaths and DALYs are due to respiratory disease. Establishment of ideal lung health in childhood is critical to reduce risk for future respiratory disease. We hypothesize that prenatal to age 1 exposure to HAP impairs lung health and programs future disease risk. We further hypothesize that higher mucin gene expression in response to HAP exposure is a key biological mechanism, and that genotypes that exhibit a stronger mucin response to HAP are more susceptible to HAP exposure. We propose to build on an existing pregnancy cohort in Ghana – the Ghana Randomized Air Pollution and Health Study, or GRAPHS – to assess how prenatal to age one HAP exposure affects lung health through age 13 years. We will use well- established, validated methods to assess these outcomes. In the long run, our research will help build the evidence base for cost effective interventions to improve health by reducing HAP exposure.

项目摘要 在低收入和中等收入国家，约有28亿人每天暴露在烹饪用火产生的烟雾中， 家庭空气污染（HAP），2019年估计导致230万人死亡和9140万人死亡。大 HAP引起的死亡和伤残的比例是由于呼吸道疾病。理想肺的建立 儿童健康对减少今后患呼吸道疾病的风险至关重要。我们假设从出生到衰老 暴露于HAP会损害肺部健康并规划未来的疾病风险。我们进一步假设， 粘蛋白基因表达对HAP暴露的反应是一个关键的生物学机制， 对HAP表现出更强的粘蛋白反应的人对HAP暴露更敏感。我们建议建立一个 加纳随机空气污染和健康研究（GRAPHS） 评估产前至1岁的HAP暴露如何影响13岁的肺部健康。我们会好好利用- 已建立的、经过验证的方法来评估这些结果。从长远来看，我们的研究将有助于建立 通过减少HAP暴露来改善健康的具有成本效益的干预措施的证据基础。