Multifunctional Porous Soft Materials for User-Friendly Skin-Interfaced Bimodal Cardiac Patches with Long-Term Biocompatibility and Antimicrobial Property

用于用户友好型皮肤界面双峰心脏贴片的多功能多孔软材料，具有长期生物相容性和抗菌特性

• 批准号: 10501905
• 负责人: Zheng Yan
• 金额: $ 70.05万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10501905
• 关键词: Accelerometer; Accounting; Address; Anti-Bacterial Agents; COVID-19; Cardiac; Caring; Cause of Death; Cessation of life; Chest; Clinical; Complement; Custom; Data; Dermatologist; Development; Devices; Early Diagnosis; Elastomers; Elderly; Electrocardiogram; Electronics; Environment; Food Preservatives; Foundations; Generations; Health Care Costs; Heart; Heart Diseases; Holter Electrocardiography; Home; Human; Hybrids; Inflammation; Inflammatory; Innovation Corps; Intervention; Interview; Lead; Measurement; Mechanics; Methods; Modality; Monitor; Motion; Myocardial; Operative Surgical Procedures; PSSO3; Pathogenicity; Patients; Performance; Persons; Phase; Physicians; Play; Polylysine; Printing; Process; Property; Pruritus; Public Health; Reaction; Recovery; Research; Role; Science; Signal Transduction; Silver; Skin; Sleep; Stress; Stretching; System; Technology; Testing; Time; Transducers; antimicrobial; antimicrobial peptide; base; bioelectronics; biomaterial compatibility; cardiogenesis; data acquisition; electrical measurement; falls; heart electrical activity; heart visualization; human subject; improved; infection risk; innovation; irritation; member; monitoring device; nanowire; natural antimicrobial; next generation; novel; personalized health care; programs; rational design; sensor; skin irritation; smart watch; usability; user-friendly; vibration; wound care; wound healing

Project Summary Long-term, continuous monitoring of heart electrical activities via electrocardiogram (ECG) plays a critical role in early diagnosis and timely interventions of various heart diseases. Concurrent detections of heart mechanics via seismocardiogram (SCG) can yield important data that complement ECG with enhanced utility in early detections of cardiac complications. However, existing ambulatory cardiac monitors are often single-modality and can only detect ECG. Moreover, they usually suffer from poor long-term usability because nonporous constituent materi- als limit their user-friendliness and long-term biocompatibility. To overcome these handicaps, this project aims to develop multifunctional porous soft materials and explore their applications in next-generation user-friendly skin-interfaced cardiac patches with bimodality (concurrent ECG and SCG recording) and long-term biocompat- ibility. The central hypothesis is that rationally designed porous constituent materials and judiciously tailored device fabrication process can enable next-generation skin-interfaced wearables with outstanding user-friendli- ness-related properties (e.g., skin-like compliance, high breathability, antimicrobial) without sacrificing their elec- trical performances. Two research aims include i) developing multifunctional porous elastomer with antimicrobial property via phase separation and investigating extrusion printing of silver nanowire-based conductive materials on obtained porous elastomers; and ii) fabricating mobile cardiac monitoring system with porous materials and evaluating its performance via on-body tests. The major innovations include (1) creation of unprecedented mul- tifunctional porous soft materials that can simultaneously achieve skin-like compliance, high breathability, anti- bacterial, and waterproof; (2) establishment of maskless, additive, high-throughput fabrications of bioelectronic devices on porous materials; and (3) generation of novel skin-interfaced cardiac patch that can outperform con- ventional ones in terms of its user-friendliness, long-term biocompatibility, and long-lasting, reliable, concurrent ECG and SCG recording. From a clinical perspective, the enabling cardiac monitoring device can shift the current paradigm of ambulatory cardiac monitoring and benefit the people who suffer from heart diseases by providing unprecedented user-friendliness for patients to wear and collecting real-time, reliable, comprehensive (ECG and SCG) data for physicians to make crucial care decisions. From a fundamental science perspective, the proposed research concerns foundational questions in skin-interfaced wearables: how to improve the user-friendliness and long-term biocompatibility of skin-interfaced wearables via material innovations (e.g., development of multifunc- tional porous soft materials) and how to fabricate high-performance bioelectronics with porous materials. From a technical perspective, the created materials and addressed fabrication principles can be used to construct various customized skin-interfaced wearables with outstanding user-friendliness, long-term biocompatibility, and long-lasting fidelity of biosignals recording to meet a variety of arising requirements of home-based, personalized healthcare (e.g., monitoring of wound healing, sleep, surgical recovery, stress, COVID-19, and elderly falls).

项目摘要 通过心电图对心脏电活动进行长期、持续的监测在 各种心脏病的早期诊断和及时干预。心脏力学的并行检测通过 地震心动图(SCG)可以产生重要的数据，以增强早期检测的实用性，补充心电图 心脏并发症的风险。然而，现有的动态心脏监护仪往往是单一模式的，只能 检测心电图。此外，它们通常遭受较差的长期可用性，因为无孔组成材料- 肌萎缩侧索硬化症限制了它们的用户友好性和长期生物兼容性。为了克服这些障碍，这个项目旨在 开发多功能多孔软质材料并探索其在下一代人性化中的应用 皮肤界面心脏补片具有双峰性(同步心电和SCG记录)和长期生物相容性。 可信度。中心假设是合理设计的多孔组成材料和明智的定制 器件制造工艺可以使下一代皮肤接口可穿戴设备具有出色的用户友好性。 与NESS相关的特性(例如，类皮肤顺应性、高透气性、抗菌性)，而不牺牲它们的电性- 真正的表演。两个研究目标包括：1)研制多功能抗菌多孔弹性体 银纳米线基导电材料的相分离及挤压印刷性能研究 2)用多孔材料制作移动式心脏监护系统， 通过身体测试来评估其性能。主要创新之处包括：(1)创造了前所未有的多人游戏。 功能齐全的多孔软质材料，可同时达到贴肤式顺应性、高透气性、防护性 细菌，防水；(2)建立无掩膜，添加，高通量的生物电子制造 多孔材料上的装置；以及(3)新型皮肤接口心脏补片的产生，其性能优于传统的心脏补片。 在用户友好性、长期生物兼容性和持久、可靠、并发方面 心电图和脑电地形图记录。从临床角度来看，使能心脏监测设备可以改变电流 动态心脏监测的范例，并通过提供 前所未有的用户友好性，让患者佩戴和采集实时、可靠、全面的(心电和 SCG)的数据，以供医生做出关键的护理决策。从基础科学的角度来看，建议的 研究涉及皮肤接口可穿戴设备的基本问题：如何提高用户友好性和 通过材料创新(例如，开发多功能可穿戴设备)实现皮肤界面可穿戴材料的长期生物兼容性 传统的多孔软质材料)以及如何利用多孔材料制造高性能生物电子学。从… 从技术角度来看，所创建的材料和所述的制造原则可用于构建 各种定制的皮肤接口可穿戴设备，具有出色的用户友好性、长期生物兼容性和 持久的生物信号记录保真度，满足各种家庭化、个性化的需求 医疗保健(例如，监测伤口愈合、睡眠、手术恢复、压力、新冠肺炎和老年跌倒)。