Multifunctional Porous Soft Materials for User-Friendly Skin-Interfaced Bimodal Cardiac Patches with Long-Term Biocompatibility and Antimicrobial Property

用于用户友好型皮肤界面双峰心脏贴片的多功能多孔软材料，具有长期生物相容性和抗菌特性

• 批准号: 10501905
• 负责人: Zheng Yan
• 金额: $ 70.05万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10501905
• 关键词: Accelerometer; Accounting; Address; Anti-Bacterial Agents; COVID-19; Cardiac; Caring; Cause of Death; Cessation of life; Chest; Clinical; Complement; Custom; Data; Dermatologist; Development; Devices; Early Diagnosis; Elastomers; Elderly; Electrocardiogram; Electronics; Environment; Food Preservatives; Foundations; Generations; Health Care Costs; Heart; Heart Diseases; Holter Electrocardiography; Home; Human; Hybrids; Inflammation; Inflammatory; Innovation Corps; Intervention; Interview; Lead; Measurement; Mechanics; Methods; Modality; Monitor; Motion; Myocardial; Operative Surgical Procedures; PSSO3; Pathogenicity; Patients; Performance; Persons; Phase; Physicians; Play; Polylysine; Printing; Process; Property; Pruritus; Public Health; Reaction; Recovery; Research; Role; Science; Signal Transduction; Silver; Skin; Sleep; Stress; Stretching; System; Technology; Testing; Time; Transducers; antimicrobial; antimicrobial peptide; base; bioelectronics; biomaterial compatibility; cardiogenesis; data acquisition; electrical measurement; falls; heart electrical activity; heart visualization; human subject; improved; infection risk; innovation; irritation; member; monitoring device; nanowire; natural antimicrobial; next generation; novel; personalized health care; programs; rational design; sensor; skin irritation; smart watch; usability; user-friendly; vibration; wound care; wound healing

Project Summary Long-term, continuous monitoring of heart electrical activities via electrocardiogram (ECG) plays a critical role in early diagnosis and timely interventions of various heart diseases. Concurrent detections of heart mechanics via seismocardiogram (SCG) can yield important data that complement ECG with enhanced utility in early detections of cardiac complications. However, existing ambulatory cardiac monitors are often single-modality and can only detect ECG. Moreover, they usually suffer from poor long-term usability because nonporous constituent materi- als limit their user-friendliness and long-term biocompatibility. To overcome these handicaps, this project aims to develop multifunctional porous soft materials and explore their applications in next-generation user-friendly skin-interfaced cardiac patches with bimodality (concurrent ECG and SCG recording) and long-term biocompat- ibility. The central hypothesis is that rationally designed porous constituent materials and judiciously tailored device fabrication process can enable next-generation skin-interfaced wearables with outstanding user-friendli- ness-related properties (e.g., skin-like compliance, high breathability, antimicrobial) without sacrificing their elec- trical performances. Two research aims include i) developing multifunctional porous elastomer with antimicrobial property via phase separation and investigating extrusion printing of silver nanowire-based conductive materials on obtained porous elastomers; and ii) fabricating mobile cardiac monitoring system with porous materials and evaluating its performance via on-body tests. The major innovations include (1) creation of unprecedented mul- tifunctional porous soft materials that can simultaneously achieve skin-like compliance, high breathability, anti- bacterial, and waterproof; (2) establishment of maskless, additive, high-throughput fabrications of bioelectronic devices on porous materials; and (3) generation of novel skin-interfaced cardiac patch that can outperform con- ventional ones in terms of its user-friendliness, long-term biocompatibility, and long-lasting, reliable, concurrent ECG and SCG recording. From a clinical perspective, the enabling cardiac monitoring device can shift the current paradigm of ambulatory cardiac monitoring and benefit the people who suffer from heart diseases by providing unprecedented user-friendliness for patients to wear and collecting real-time, reliable, comprehensive (ECG and SCG) data for physicians to make crucial care decisions. From a fundamental science perspective, the proposed research concerns foundational questions in skin-interfaced wearables: how to improve the user-friendliness and long-term biocompatibility of skin-interfaced wearables via material innovations (e.g., development of multifunc- tional porous soft materials) and how to fabricate high-performance bioelectronics with porous materials. From a technical perspective, the created materials and addressed fabrication principles can be used to construct various customized skin-interfaced wearables with outstanding user-friendliness, long-term biocompatibility, and long-lasting fidelity of biosignals recording to meet a variety of arising requirements of home-based, personalized healthcare (e.g., monitoring of wound healing, sleep, surgical recovery, stress, COVID-19, and elderly falls).

项目摘要 通过心电图（ECG）长期，连续监测心脏电活动在 早期诊断和及时干预各种心脏病。通过 地震心动图（SCG）可以产生重要数据，使ECG与早期检测中的效用相互补充 心脏并发症。但是，现有的门诊心脏监测机通常是单模式的，只能 检测ECG。而且，它们通常遭受长期可用性差的障碍 ALS限制其用户友好性和长期生物相容性。为了克服这些障碍，该项目的目标 开发多功能软材料并探索其在下一代用户友好的应用 具有双峰性（同时ECG和SCG记录）和长期生物形成性的皮肤裂化心脏斑块 令人讨厌。中心假设是合理设计的多孔组成材料和明智地量身定制的 设备制造工艺可以使下一代皮肤融合可穿戴设备具有出色的用户友好 与NESS相关的特性（例如，皮肤状的合规性，高透气性，抗菌素）而不牺牲其电子 三方面的表演。两个研究的目的包括i）与抗菌剂开发多功能的多孔弹性体 通过相位分离和调查银纳米线导电材料的挤出打印的财产 在获得的多孔弹性体上； ii）用多孔材料制造移动心脏监测系统， 通过体内测试评估其性能。主要创新包括（1）创建前所未有的穆尔 可以同时达到皮肤的合规性，高透气性，抗 - 细菌和防水； （2）建立生物电子的无掩模，添加剂，高通量的制造 多孔材料的设备； （3）新型的皮肤相互裂缝的心脏斑块可以超越表现 关于其用户友好性，长期生物相容性和持久，可靠，并发的通行性 ECG和SCG记录。从临床角度来看，启用心脏监测装置可以改变电流 通过提供心脏疾病的室外心脏监测范式和受益于患有心脏病的人 空前的用户友好性供患者实时佩戴和收集实时，可靠，全面（ECG和ECG） SCG）医生做出关键护理决定的数据。从基本的科学角度来看，拟议的 研究涉及皮肤交织可穿戴设备中的基本问题：如何改善用户友好性和 皮肤脱落可穿戴设备的长期生物相容性通过材料创新（例如，多孔的发展 多孔的多孔软材料）以及如何用多孔材料制造高性能的生物电子。从 技术观点，创建的材料和涉及的制造原理可用于构建 各种定制的皮肤融化可穿戴设备，具有出色的用户友好性，长期生物相容性和 生物信号记录的长期忠诚度以满足基于家庭的个性化的各种要求 医疗保健（例如，监测伤口愈合，睡眠，手术恢复，压力，COVID-19和老年跌倒）。