Multifunctional Porous Soft Materials for User-Friendly Skin-Interfaced Bimodal Cardiac Patches with Long-Term Biocompatibility and Antimicrobial Property

用于用户友好型皮肤界面双峰心脏贴片的多功能多孔软材料，具有长期生物相容性和抗菌特性

• 批准号: 10689824
• 负责人: Zheng Yan
• 金额: $ 65.43万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10689824
• 关键词: Accelerometer; Accounting; Address; Anti-Bacterial Agents; Artificial Heart; COVID-19; Cardiac; Caring; Cause of Death; Cessation of life; Chest; Clinical; Complement; Data; Dermatologist; Development; Devices; Early Diagnosis; Elasticity; Elastomers; Elderly; Electrocardiogram; Electronics; Food Preservatives; Foundations; Generations; Health Care Costs; Heart; Heart Diseases; Holter Electrocardiography; Home; Human; Hybrids; Inflammation; Inflammatory; Innovation Corps; Intervention; Interview; Lead; Measurement; Mechanics; Methods; Modality; Monitor; Motion; Myocardial; Operative Surgical Procedures; PSSO3; Pathogenicity; Patients; Performance; Persons; Phase; Physicians; Play; Polylysine; Porosity; Printing; Process; Property; Pruritus; Public Health; Reaction; Recovery; Research; Role; Science; Signal Transduction; Silver; Skin; Sleep; Stress; System; Technology; Testing; Time; Transducers; antimicrobial; antimicrobial peptide; bioelectronics; biomaterial compatibility; data acquisition; elastomeric; fabrication; falls; heart electrical activity; heart visualization; human subject; improved; infection risk; innovation; irritation; member; monitoring device; nanowire; natural antimicrobial; next generation; novel; personalized health care; programs; rational design; sensor; skin irritation; smart watch; usability; user-friendly; vibration; wearable device; wound care; wound healing

Project Summary Long-term, continuous monitoring of heart electrical activities via electrocardiogram (ECG) plays a critical role in early diagnosis and timely interventions of various heart diseases. Concurrent detections of heart mechanics via seismocardiogram (SCG) can yield important data that complement ECG with enhanced utility in early detections of cardiac complications. However, existing ambulatory cardiac monitors are often single-modality and can only detect ECG. Moreover, they usually suffer from poor long-term usability because nonporous constituent materi- als limit their user-friendliness and long-term biocompatibility. To overcome these handicaps, this project aims to develop multifunctional porous soft materials and explore their applications in next-generation user-friendly skin-interfaced cardiac patches with bimodality (concurrent ECG and SCG recording) and long-term biocompat- ibility. The central hypothesis is that rationally designed porous constituent materials and judiciously tailored device fabrication process can enable next-generation skin-interfaced wearables with outstanding user-friendli- ness-related properties (e.g., skin-like compliance, high breathability, antimicrobial) without sacrificing their elec- trical performances. Two research aims include i) developing multifunctional porous elastomer with antimicrobial property via phase separation and investigating extrusion printing of silver nanowire-based conductive materials on obtained porous elastomers; and ii) fabricating mobile cardiac monitoring system with porous materials and evaluating its performance via on-body tests. The major innovations include (1) creation of unprecedented mul- tifunctional porous soft materials that can simultaneously achieve skin-like compliance, high breathability, anti- bacterial, and waterproof; (2) establishment of maskless, additive, high-throughput fabrications of bioelectronic devices on porous materials; and (3) generation of novel skin-interfaced cardiac patch that can outperform con- ventional ones in terms of its user-friendliness, long-term biocompatibility, and long-lasting, reliable, concurrent ECG and SCG recording. From a clinical perspective, the enabling cardiac monitoring device can shift the current paradigm of ambulatory cardiac monitoring and benefit the people who suffer from heart diseases by providing unprecedented user-friendliness for patients to wear and collecting real-time, reliable, comprehensive (ECG and SCG) data for physicians to make crucial care decisions. From a fundamental science perspective, the proposed research concerns foundational questions in skin-interfaced wearables: how to improve the user-friendliness and long-term biocompatibility of skin-interfaced wearables via material innovations (e.g., development of multifunc- tional porous soft materials) and how to fabricate high-performance bioelectronics with porous materials. From a technical perspective, the created materials and addressed fabrication principles can be used to construct various customized skin-interfaced wearables with outstanding user-friendliness, long-term biocompatibility, and long-lasting fidelity of biosignals recording to meet a variety of arising requirements of home-based, personalized healthcare (e.g., monitoring of wound healing, sleep, surgical recovery, stress, COVID-19, and elderly falls).

项目摘要 通过心电图（ECG）对心脏电活动进行长期、连续监测， 各种心脏病的早期诊断和及时干预。心脏力学的同时检测， 心震图（SCG）可以产生重要数据，补充ECG，在早期检测中具有增强的实用性 心脏并发症然而，现有的流动心脏监测器通常是单模态的，并且仅能够 检测ECG。此外，它们通常遭受差的长期可用性，因为无孔组成材料， ALS限制了它们的用户友好性和长期生物相容性。为了克服这些障碍，该项目旨在 开发多功能多孔软材料，并探索其在下一代用户友好型 具有双模态（同步ECG和SCG记录）和长期生物相容性的皮肤界面心脏贴片， - 是的中心假设是，合理设计的多孔组成材料和明智的定制 设备制造工艺可以使下一代皮肤界面可穿戴设备具有出色的用户友好性， 与属性相关的属性（例如，类似皮肤顺应性、高透气性、抗菌性），而不牺牲其透气性， 戏剧表演本研究的两个主要目的是：（1）开发具有抗菌功能的多孔弹性体 银石基导电材料的相分离性能及挤出印刷研究 ii）用多孔材料制造移动的心脏监测系统， 通过身体测试评估其性能。主要创新包括（1）创建前所未有的穆尔- 双功能多孔柔软材料，可同时实现皮肤般的顺应性，高透气性，抗 细菌，防水;（2）建立无掩模，添加剂，生物电子高通量制造 多孔材料上的装置;和（3）产生新型皮肤界面心脏补片，其性能优于传统心脏补片。 在其用户友好性、长期生物相容性和持久、可靠、并发性方面， ECG和SCG记录。从临床角度来看，启用心脏监测设备可以将电流 提供动态心脏监测的范例，并通过提供 前所未有的用户友好性，可供患者佩戴和采集实时、可靠、全面（ECG和 SCG）数据，以便医生做出关键的护理决策。从基础科学的角度来看， 研究关注皮肤界面可穿戴设备的基本问题：如何提高用户友好性， 经由材料创新的皮肤界面可穿戴设备的长期生物相容性（例如，多功能开发 以及如何用多孔材料制造高性能生物电子器件。从 从技术角度来看，所创建的材料和所解决的制造原理可以用于构建 各种定制的皮肤界面可穿戴设备，具有出色的用户友好性，长期生物相容性， 生物信号记录的持久保真度，以满足家庭化，个性化的各种需求 医疗保健（例如，监测伤口愈合、睡眠、手术恢复、压力、COVID-19和老年福尔斯）。

项目成果

Phase-separated porous nanocomposite with ultralow percolation threshold for wireless bioelectronics.

• DOI: 10.1038/s41565-024-01658-6
• 发表时间: 2024-04
• 期刊: Nature nanotechnology
• 影响因子: 38.3
• 作者: Yadong Xu;Zhilu Ye;Ganggang Zhao;Qihui Fei;Zehua Chen;Jiahong Li;Minye Yang;Yichong Ren;Benton Berigan;Yun Ling;Xiaoyan Qian;Lin Shi;Ilker Ozden;Jingwei Xie;Wei Gao;Pai-Yen Chen;Zheng Yan