Cherenkov imaging incorporating 3D surface imaging for TSET
切伦科夫成像结合 TSET 的 3D 表面成像
基本信息
- 批准号:10500899
- 负责人:
- 金额:$ 47.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2027-08-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAgreementAlgorithmsAnatomyCancer PatientClinicalClinical TrialsCollaborationsComputer softwareComputersDataDependenceDevelopmentDoseDose-RateElectronsElementsEngineeringEnsureFoundationsGeometryGoalsHumanHybridsImageImaging technologyIncidenceLightLinear Accelerator Radiotherapy SystemsLocationMapsMeasurementMeasuresMethodsMonitorMonte Carlo MethodMovementMycosis FungoidesOpticsPatientsPhotonsPhysiologic pulsePilot ProjectsPositioning AttributePostureProceduresPropertyRadiationRadiation Dose UnitRadiation MonitoringRadiation therapyReportingScanningSchoolsSignal TransductionSiteSkinSkin TissueSoftware ToolsSolidSurfaceSystemTechniquesTechnologyTestingTimeTissuesUmbilicusUncertaintyVisualabsorptionanimationbasebody positioncherenkov imagingdetectordosimetryimprovedin vivoindividual patientlight scatteringoptical spectraprospectivepublic health relevanceradiation deliverysimulationsoftware systemssupport toolstooltreatment planningtwo-dimensional
项目摘要
Cherenkov imaging incorporating surface imaging for TSET
Abstract
Whole-body skin electron radiotherapy has been clinically demonstrated to be effective to treat mycosis
fungoides. However, due to setup positioning uncertainties and potential patient movements during
total skin electron therapy (TSET), dose delivered to the patient skin tissue can deviate from dose
prescription. Cherenkov emission from tissue has recently been demonstrated, providing a mapping
related to the radiation delivery to skin tissue. The signal is optimally captured by time-gated intensified
cameras, synchronized to the linear accelerator pulses, allowing rejection of the majority of background
room light, and providing real time video of each radiotherapy treatment with high dose rates. The
implementation of Cherenkov imaging offers an excellent technology to detect abnormalities in the
treatment, which would otherwise go unnoticed. This proposal seeks to advance this technology as a
verification tool through a clinical trial to monitor the daily treatment delivery of TSET patients and
develop proper corrections that can be applied to the acquired signal to ensure it is quantitatively
accurate in documenting delivered skin dose. Three of the most dominant factors, which alter the
linearity between dose and Cherenkov signal, are the corrections for perspective direction, tissue
curvature, and tissue optical properties. These important corrections are quantified in this pilot study of
TSET, in partnership with DoseOptics LLC, the company that developed the Cherenkov imaging
technology for radiation verification, to perfect technology for daily monitoring of radiation delivery. We
will compare the dosimetry accuracy of Cherenkov imaging by comparing measurements in-vivo at 9
locations using OSLD and Scintillator detectors. In addition, we will perform measurements in optical
phantoms of known tissue optical properties at TSE treatment conditions and Monte-Carlo simulation
studies to quantity the three correction factors. We will also develop techniques to overlay skin dose
obtained from corrected Cherenkov image to patient-specific surface anatomy based on surface 3D
body contour data obtained before TSE treatment to assess the actual skin dose distribution for daily
TSE treatment and perform a comprehensive comparison of dose distribution based on MC-based
treatment planning system. Taking together, this project will advance on the most compelling systems
for radiotherapy imaging in decades. The core of the project is combined technology systems, testing
the utility in the setting of TSET.
Cherenkov成像结合表面成像用于TSET
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Timothy C. Zhu其他文献
The head-scatter factor for small field sizes.
小视场尺寸的头部散射系数。
- DOI:
- 发表时间:
1994 - 期刊:
- 影响因子:0
- 作者:
Timothy C. Zhu;B. Bjärngard - 通讯作者:
B. Bjärngard
Photobleaching as an optimization variable for the macroscopic model of singlet oxygen in PDT
- DOI:
10.1016/j.pdpdt.2015.07.028 - 发表时间:
2015-09-01 - 期刊:
- 影响因子:
- 作者:
Michele M. Kim;Jarod C. Finlay;Timothy C. Zhu - 通讯作者:
Timothy C. Zhu
Reactive Oxygen Species Explicit dosimetry for Pleural PDT
- DOI:
10.1016/j.pdpdt.2024.104164 - 发表时间:
2024-04-01 - 期刊:
- 影响因子:
- 作者:
Timothy C. Zhu;Hongjing Sun;Weibing Yang;Andreea Dimofte;Sunil Singhal;Keith A. Cengel - 通讯作者:
Keith A. Cengel
Performance characterization of a low-cost spatial frequency domain imaging system for the determination of optical properties in tissue-simulating phantoms and in vivo
- DOI:
10.1016/j.pdpdt.2015.07.032 - 发表时间:
2015-09-01 - 期刊:
- 影响因子:
- 作者:
Arash Darafsheh;Emily A. Kraus;Michele M. Kim;Timothy C. Zhu;Jarod C. Finlay - 通讯作者:
Jarod C. Finlay
Determination of light fluence inside a pleural cavity
- DOI:
10.1016/j.pdpdt.2015.07.081 - 发表时间:
2015-09-01 - 期刊:
- 影响因子:
- 作者:
Michele M. Kim;Rozhin Penjweini;Timothy C. Zhu - 通讯作者:
Timothy C. Zhu
Timothy C. Zhu的其他文献
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{{ truncateString('Timothy C. Zhu', 18)}}的其他基金
Cherenkov imaging incorporating 3D surface imaging for TSET
切伦科夫成像结合 TSET 的 3D 表面成像
- 批准号:
10689148 - 财政年份:2022
- 资助金额:
$ 47.28万 - 项目类别:
Cherenkov imaging of Total Skin Electron Therapy (TSET)
全皮肤电子治疗 (TSET) 的切伦科夫成像
- 批准号:
10059190 - 财政年份:2019
- 资助金额:
$ 47.28万 - 项目类别:
Image-guided treatment planning for pleural Photodynamic Therapy
图像引导的胸膜光动力治疗治疗计划
- 批准号:
8777007 - 财政年份:2012
- 资助金额:
$ 47.28万 - 项目类别:
Image-guided treatment planning for pleural Photodynamic Therapy
图像引导的胸膜光动力治疗治疗计划
- 批准号:
8585834 - 财政年份:2012
- 资助金额:
$ 47.28万 - 项目类别:
Image-guided treatment planning for pleural Photodynamic Therapy
图像引导的胸膜光动力治疗治疗计划
- 批准号:
8442277 - 财政年份:2012
- 资助金额:
$ 47.28万 - 项目类别:
Real-Time PDT Dosimetry with Feedback Light Delivery
带反馈光传输的实时 PDT 剂量测定
- 批准号:
7406812 - 财政年份:2005
- 资助金额:
$ 47.28万 - 项目类别:
Real-Time PDT Dosimetry with Feedback Light Delivery
带反馈光传输的实时 PDT 剂量测定
- 批准号:
6985587 - 财政年份:2005
- 资助金额:
$ 47.28万 - 项目类别:
Real-Time PDT Dosimetry with Feedback Light Delivery
带反馈光传输的实时 PDT 剂量测定
- 批准号:
7237274 - 财政年份:2005
- 资助金额:
$ 47.28万 - 项目类别:
Real-Time PDT Dosimetry with Feedback Light Delivery
带反馈光传输的实时 PDT 剂量测定
- 批准号:
7082947 - 财政年份:2005
- 资助金额:
$ 47.28万 - 项目类别:
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