PDT Physics Core

PDT物理核心

• 批准号: 8219263
• 负责人: Timothy C. Zhu
• 金额: $ 19.38万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-07 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8219263
• 关键词: Blood flow; Cells; Clinical Treatment; Clinical Trials; Devices; Disease; Ensure; Equipment; Fluorescence Spectroscopy; Goals; Housing; Human; Individual; Institutes; Lasers; Light; Lung diseases; Measurement; Mus; Optics; Output; Patients; Pharmaceutical Preparations; Photochemotherapy; Physics; Pleural; Property; Safety; Science; Source; Surface; System; Techniques; Technology; Tissues; Translating; Work; absorption; cancer therapy; clinical application; dosimetry; improved; in vivo; intraperitoneal; neoplastic; quality assurance; research study; tissue oxygenation; treatment planning

The goals of the PDT Physics core are to: 1) Provide Laser and other light source support for all projects; 2) Perform high-quality and reliable in vivo light dosimetry for projects (1,3,4 and 5); 3) Provide absolute light dosimetry standards for all projects; 4) Provide explicit PDT dosimetry for tissue optical properties, drug concentrations, and tissue oxygenation before, after, and during PDT. The physics core is responsible for calibrating the absolute output power of laser sources, ensuring that they are traceable to standards maintained by the National Institute of Science and Technology (NIST). The core performs in vivo light dosimetry to achieve accurate light fluence measurement in PDT treatments, such as the Intraperitoneal and Pleural PDT studies. Laser equipment operating at treatment wavelengths (532-730 nm) for PDT are maintained, along with light sources covering wavelengths between 400 - 900 nm for absorption and fluorescence spectroscopy. The physics core translates the spectroscopic techniques developed in the physics project for in vivo PDT dosimetry into clinical trials. The physics core ensures laser safety, maintains quality assurance of physics equipment, and works to characterize light fluence distributions in tissue. It helps to implement useful technologies developed in the physics project (Project 4) to routine clinical applications.

PDT物理核心的目标是：1）为所有项目提供激光和其他光源支持; 2） 为项目（1、3、4和5）进行高质量和可靠的体内光剂量测定; 3）提供绝对光 所有项目的剂量测定标准; 4）为组织光学特性、药物提供明确的PDT剂量测定 在PDT之前、之后和过程中的浓度和组织氧合。 物理核心负责校准激光源的绝对输出功率，确保它们 可追溯至美国国家科学技术研究所（NIST）维护的标准。核心 进行体内光剂量测定，以实现PDT治疗中精确的光通量测量，例如 腹膜内和胸膜PDT研究。在治疗波长下运行的激光设备（532-730 沿着，光源覆盖400 - 900 nm之间的波长， 吸收和荧光光谱。物理核心将光谱技术 在物理项目中开发的用于体内PDT剂量测定的临床试验。物理核心确保激光 安全，保持物理设备的质量保证，并致力于表征光通量 组织中的分布。它有助于实现物理项目（项目4）中开发的有用技术 常规临床应用。