An Immersive, Interdisciplinary Training Program for Workforce Development and Sustained Engagement in Entrepreneurship and Translational Research for Alzheimer's Disease and Related Disorders

沉浸式跨学科培训计划，旨在促进劳动力发展和持续参与阿尔茨海默病及相关疾病的创业和转化研究

• 批准号: 10501041
• 负责人: Nalaka S Gooneratne
• 金额: $ 16.19万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10501041
• 关键词: Active Learning; Alzheimer' s Disease; Applications Grants; Businesses; Diagnostic; Disease; Entrepreneurship; Funding; Grant; Immersion; Pathway interactions; Research; Therapeutic Intervention; Training; Training Programs; Translational Research; United States National Institutes of Health; Workforce Development; innovation; product development

Project Summary This is an entrepreneurship-focused educational program with the overarching goal of training the workforce of the future with the necessary broad knowledge base required for the successful commercialization of promising clinical and translational research that will help to address the growing public health crisis posed by Alzheimer’s Disease and AD Related Disorders (ADRD). We will be taking a national approach to this challenging area in order to engage with the most promising graduate and postdoctoral researchers from around the country, leveraging the robust NIH investment in Alzheimer’s Disease Research Centers (ADRCs) and Clinical and Translational Science Award (CTSA) programs. This R25 program will provide trainees with a keen understanding of the interdisciplinary, clinical and translational nature of research and commercialization related to ADRD, how it depends on fundamental underpinnings of both science, engineering and regulatory science, and how commercial products are developed. The knowledge base, mentorship and ecosystem supported by this R25 will help them prepare competitive SBIR/STTR grants to further their work. We have identified a robust network of commercial, regulatory and academic experts that will allow us to address our core aims: 1) Training in entrepreneurial skill development for ADRD technologies in a structured didactic curriculum that includes foundational elements, case-based learning, and personalized components tailored to their specific domain (i.e., ADRD small molecule development, biologics, digital health, etc.) leveraging the extensive resources developed at the University of Pennsylvania, including the Academic Entrepreneurship for Medical and Health Scientists textbook (of which Dr. Gooneratne is the lead editor); 2) Mentored research experience with tailored guidance to maximize stakeholder/customer discovery and product iteration and experiential learning opportunities to complement any gaps in their commercialization plans; 3) Curriculum development through innovative modification of Individual Development Plans (IDPs) to incorporate entrepreneurship; and 4) Workforce diversity enhancement through efforts to support participation of under-represented minorities (URM). Five to ten trainees will be enrolled each year, and they will have a research mentor, a business mentor and an R25 program mentor to ensure that they receive comprehensive support and guidance. Trainees will participate in the program for two years, with the first year dedicated to learning and development with the goal of submitting an initial SBIR/STTR grant application by month 15 or sooner, then the second year devoted to additional activities to support a grant resubmission or successfully initiate the funded grant. We seek ultimately to develop a community of highly trained entrepreneurs and researchers in ADRD that can engage in interdisciplinary team science with sustained engagement through an active, participatory ecosystem to serve as the nidus for meaningful advances as we confront the looming healthcare challenge posed by ADRD.

项目摘要 这是一个以创业为重点的教育计划，总体目标是培训未来的劳动力，拥有必要的广泛知识基础，以成功地将有前途的临床和转化研究商业化，这些研究将有助于解决阿尔茨海默氏症和AD相关疾病(ADRD)带来的日益严重的公共健康危机。我们将在这个具有挑战性的领域采取全国性的方法，以便接触到来自全国各地最有前途的研究生和博士后研究人员，利用NIH对阿尔茨海默病研究中心(ADRC)以及临床和翻译科学奖(CTSA)计划的强劲投资。该R25项目将为学员提供对与ADRD相关的研究和商业化的跨学科、临床和翻译性质的敏锐理解，它如何依赖于科学、工程和监管科学的基本基础，以及商业产品是如何开发的。R25所支持的知识库、指导和生态系统将帮助他们准备具有竞争力的SBIR/STTR赠款，以进一步开展他们的工作。 我们已经确定了一个由商业、监管和学术专家组成的强大网络，这将使我们能够实现我们的核心目标：1)在结构化教学课程中为ADRD技术提供创业技能发展培训，其中包括基础元素、基于案例的学习和针对其特定领域量身定做的个性化组件(即ADRD小分子开发、生物制品、数字健康等)。利用宾夕法尼亚大学开发的广泛资源，包括医学和健康科学家学术创业教科书(Gooneratne博士是该教科书的主编)；2)通过量身定制的指导，最大限度地指导研究经验，以最大限度地发现利益相关者/客户，并提供产品迭代和体验式学习机会，以弥补其商业化计划中的任何空白；3)通过创新修改个人发展计划(IDP)来制定课程，以纳入创业精神；以及4)通过努力支持代表不足的少数群体(URM)的参与，增强劳动力多样性。每年招收5至10名学员，他们将拥有一名研究导师、一名商业导师和一名R25项目导师，以确保他们得到全面的支持和指导。学员将参加为期两年的计划，第一年致力于学习和发展，目标是在15个月或更早之前提交SBIR/STTR的初始赠款申请，然后第二年专门用于支持重新提交赠款或成功启动资助赠款的额外活动。我们最终寻求在ADRD建立一个由训练有素的企业家和研究人员组成的社区，能够通过积极、参与式的生态系统持续参与跨学科团队科学，在我们应对ADRD带来的迫在眉睫的医疗挑战时，作为有意义进展的核心。