Sudden Death Associated with Substance Use

与药物使用相关的猝死

• 批准号: 10508030
• 负责人: Faye Norby
• 金额: $ 14.12万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10508030
• 关键词: Address; Affect; Arrhythmia; Autopsy; Cardiac; Cardiovascular system; Caring; Cessation of life; Clinical; Clinical Data; Cocaine; Communities; County; Data; Drug Combinations; Drug usage; Elements; Epidemiology; Event; Familiarity; Frequencies; Funding; General Population; Goals; Grant; Heart; Heart Arrest; Home; Hypertrophic Cardiomyopathy; Individual; Infrastructure; Institutes; Investigative Reports; K-Series Research Career Programs; Knowledge; Lead; Location; Long QT Syndrome; Measures; Mental disorders; Mentored Research Scientist Development Award; Mentorship; Methods; Motivation; National Heart, Lung, and Blood Institute; Opioid; Overdose; Persons; Pharmaceutical Preparations; Pharmacoepidemiology; Phenotype; Physiologic pulse; Plasma; Population; Prevention; Prevention approach; Public Health; Publishing; Reaction Time; Records; Registries; Reporting; Research; Research Activity; Research Design; Research Personnel; Research Training; Resources; Resuscitation; Series; Sudden Death; Survival Rate; System; Toxicology; Training; Training Activity; United States; Work; base; career development; community setting; data archive; design; epidemiology study; health record; high risk population; improved; injury-related death; mortality; multimodality; non-drug; non-opioid analgesic; novel; opioid epidemic; out-of-hospital cardiac arrest; overdose death; polysubstance use; prevent; programs; prospective; psychostimulant; response; skills; substance use; survival prediction; synthetic opioid; tool

PROJECT SUMMARY Sudden cardiac arrest (SCA), a sudden catastrophic loss of the pulse, continues to be a major public health issue. A proportion of SCA events occur in persons engaging in drug use and given that drug overdose deaths are at unprecedented levels in the United States, the epidemiology of drug related SCA is changing rapidly. Recognition and characterization of drug related SCA events is critical for accurate estimates of mortality associated with drug use, and to inform public health measures, especially in the context of the ongoing opioid epidemic. This proposed study will address several of the major knowledge gaps. This K01 Career Development Award leverages the existing infrastructure and clinical data archive of two ongoing prospective community-based studies of SCA. Dr. Norby will use this data to examine the epidemiology of SCA associated with drug use, with the overall goal of improving community-based approaches to SCA prevention. This proposal aims to 1) identify opportunities that will improve survival from SCA in the setting of drug use, and 2) identify substrate-trigger factors that initiate SCA in the presence of drug use. Taken together, these aims will interface community-based surveillance and comprehensive investigative reports to fill in the epidemiology and research gaps in SCA events related to substance use. To address these research aims, Dr. Norby will assemble records and reports in these two communities for SCA cases that have previously been excluded due to evidence of drug use. The overall goal of this K01 is to inform a sequence of R series grants to further investigate the prediction and prevention of SCA, and to improve survival after an SCA event related to drug use. With the support of this K01 award, Dr. Norby will be able to pursue this goal and transition to independent investigator status through essential training and mentorship. She will gain advanced training in 1) combining multimodal health records across systems and extracting pertinent information; 2) pharmacoepi drug use research and analysis of drug-drug combination; and 3) SCA mechanisms, SCA response and care, and additionally gain familiarity with toxicology and autopsy reports. Cedars-Sinai Smidt Heart Institute provides the ideal infrastructure to complete the research and training activities. Through the proposed research, training, and career development Dr. Norby will gain the scientific and professional skills necessary to become a successful independent investigator and lead a research program that advances the field of SCA associated with drug use.

项目摘要 心脏骤停（SCA）是一种突然的灾难性脉搏丧失，仍然是一种主要的公共健康问题。 问题.一定比例的SCA事件发生在药物使用者中，并且药物过量 在美国，死亡人数处于前所未有的水平，与药物相关的SCA的流行病学正在发生变化 迅速药物相关SCA事件的识别和表征对于准确估计 与吸毒有关的死亡率，并为公共卫生措施提供信息，特别是在 阿片类药物的流行这项拟议的研究将解决几个主要的知识差距。K01 职业发展奖利用现有的基础设施和临床数据档案， SCA的前瞻性社区研究。诺比博士将利用这些数据来研究 与药物使用相关的严重急性呼吸道感染，总体目标是改进以社区为基础的应对严重急性呼吸道感染的方法 预防本提案旨在：1）确定可改善SCA生存的机会， 药物使用的设置，和2）确定在药物使用的存在下启动SCA的底物触发因子。 总之，这些目标将结合以社区为基础的监测和全面的调查， 报告，以填补与物质使用有关的SCA事件的流行病学和研究空白。解决 为了达到这些研究目的，诺比博士将收集这两个社区的SCA病例记录和报告 之前因为有吸毒证据而被排除在外本K 01的总体目标是告知 一系列R系列赠款，以进一步研究SCA的预测和预防，并提高 与药物使用相关的SCA事件后的生存率。在K 01奖的支持下，诺比博士将能够 追求这一目标，并通过必要的培训过渡到独立调查员的地位， 导师制她将获得1）跨系统组合多模式健康记录的高级培训 并提取相关信息; 2）药物表药物使用研究和药物-药物分析 组合;和3）SCA机制，SCA反应和护理，并额外熟悉 毒理学和尸检报告雪松西奈山心脏研究所提供了理想的基础设施， 完成研究和培训活动。通过拟议的研究、培训和职业生涯， 诺比博士将获得必要的科学和专业技能，成为一个成功的 独立调查员，并领导一项研究计划，推进与药物相关的SCA领域 使用.