Administrative Core

项目总结--行政核心 行政核心将提供必要的基础设施，以确保有效的协调、整合、 规划和评估与拟议的CAP-IT中心相关的所有代理发现活动。《核心》 为参与成员之间的科学协作提供综合的多学科框架 和fccc的共享资源。为了促进生产力，行政核心将提供财政 管理和文书支助，以及确保科学严谨性、数据重复性、重视 生物变量、透明度和一致的沟通。重要的是，行政核心将服务于 作为NCI和其他专门的CAP-IT中心的联络人，并利用信息学的支持 核心以有效地与数据和资源协调中心接触。CAP-IT的积极参与 参加履约协助方案--信息技术网络会议、讲习班和活动的成员将通过 管理核心。这些活动将根据四个具体目标来完成：1)保持 通过强大的沟通和应用，有效地整合多学科研究活动 组织能力，并经常监测研究进展；2)通过以下方式促进跨网络合作 协调和参加履约协助方案-IT网络会议，组织方案间研讨会和 讲习班；3)让早期调查人员参与精确的癌症预防-拦截研究和 向科学界传播研究结果和能力；以及4)评估拟议的 CAP-使用标准交付成果和定义的成功指标和里程碑的IT中心。领导层 团队由在遗传性癌症综合征、靶点验证、 药剂筛选、体内疗效测试和信息学将监督研究的所有方面 项目，并在发现管道的关键时刻做出明智的决定。与……密切协商 NCI、FCCC CAP-IT将利用其独特的资源和技术专长来推动 在CAP-IT网络内外用于癌症预防和拦截的代理。

PROJECT SUMMARY - ADMINISTRATIVE CORE The Administrative Core will provide the infrastructure required to ensure efficient coordination, integration, planning, and evaluation of all agent discovery activities associated with the proposed CAP-IT Center. The Core provides an integrated multidisciplinary framework for scientific collaboration among the participating members and Shared Resources at FCCC. To facilitate productivity, the Administrative Core will provide fiscal management and clerical support, as well as ensure scientific rigor, data reproducibility, attention to important biological variables, transparency, and consistent communication. Importantly, the Administrative Core will serve as a liaison with the NCI and other Specialized CAP-IT Centers, and leverage the support of the Informatics Core to effectively engage with the Data and Resource Coordinating Center. Active participation of CAP-IT members in meetings, workshops and activities of the CAP-IT Network will be coordinated through the Administrative Core. These activities will be accomplished according to four specific aims to: 1) Maintain an effective framework of well-integrated multidisciplinary research activities by applying strong communication and organizational skills, and frequently monitoring research progress; 2) Promote trans-Network collaborations by coordinating and participating in CAP-IT Network meetings, and organizing inter-programmatic seminars and workshops; 3) Engage early-stage investigators in precision cancer prevention – interception research and disseminate findings and capabilities to the scientific community; and 4) Evaluate the progress of the proposed CAP-IT Center using standard deliverables and defined metrics and milestones of success. The Leadership Team, comprised of accomplished investigators with expertise in hereditary cancer syndromes, target validation, agent screening, in vivo efficacy testing, and informatics, will provide oversight of all aspects of the research projects, and make informed decisions at critical junctures of the discovery pipeline. In close consultation with the NCI, the FCCC CAP-IT will leverage its unique resources and technical expertise to fuel the discovery of agents for cancer prevention and interception within the CAP-IT Network and beyond.