Administrative Core

项目摘要-行政核心 行政核心将提供确保高效协调、整合所需的基础设施， 规划和评估与建议的CAP-IT中心相关的所有代理发现活动。核心 为参与成员之间的科学合作提供了一个综合的多学科框架 和FCCC的共享资源。为了提高生产力，行政核心将提供财政支持， 管理和文书支持，以及确保科学的严谨性，数据的可重复性，重视重要的 生物变量、透明度和一致的沟通。重要的是，行政核心将 作为与NCI和其他专门的CAP-IT中心的联络人，并利用信息学的支持 核心是有效地与数据和资源协调中心合作。CAP-IT的积极参与 将通过协调委员会协调成员参加信息技术协助方案网络的会议、讲习班和活动， 行政核心。这些活动将根据四个具体目标来完成，即： 通过强有力的沟通和交流，建立有效的多学科综合研究活动框架， 组织能力，并经常监测研究进展; 2）促进跨网络合作， 协调和参加信息技术能力建设方案网络会议，组织方案间研讨会， 3）让早期研究人员参与精确癌症预防-拦截研究， 向科学界传播研究结果和能力; 4）评估拟议的 CAP-IT中心使用标准交付成果和定义的成功指标和里程碑。领导 团队，由在遗传性癌症综合征，目标验证， 药物筛选、体内功效测试和信息学将对研究的各个方面进行监督 项目，并在发现管道的关键节点做出明智的决策。密切协同 作为国家癌症研究所，气候变化框架公约CAP-IT将利用其独特的资源和技术专长， CAP-IT网络内外的癌症预防和拦截剂。

PROJECT SUMMARY - ADMINISTRATIVE CORE The Administrative Core will provide the infrastructure required to ensure efficient coordination, integration, planning, and evaluation of all agent discovery activities associated with the proposed CAP-IT Center. The Core provides an integrated multidisciplinary framework for scientific collaboration among the participating members and Shared Resources at FCCC. To facilitate productivity, the Administrative Core will provide fiscal management and clerical support, as well as ensure scientific rigor, data reproducibility, attention to important biological variables, transparency, and consistent communication. Importantly, the Administrative Core will serve as a liaison with the NCI and other Specialized CAP-IT Centers, and leverage the support of the Informatics Core to effectively engage with the Data and Resource Coordinating Center. Active participation of CAP-IT members in meetings, workshops and activities of the CAP-IT Network will be coordinated through the Administrative Core. These activities will be accomplished according to four specific aims to: 1) Maintain an effective framework of well-integrated multidisciplinary research activities by applying strong communication and organizational skills, and frequently monitoring research progress; 2) Promote trans-Network collaborations by coordinating and participating in CAP-IT Network meetings, and organizing inter-programmatic seminars and workshops; 3) Engage early-stage investigators in precision cancer prevention – interception research and disseminate findings and capabilities to the scientific community; and 4) Evaluate the progress of the proposed CAP-IT Center using standard deliverables and defined metrics and milestones of success. The Leadership Team, comprised of accomplished investigators with expertise in hereditary cancer syndromes, target validation, agent screening, in vivo efficacy testing, and informatics, will provide oversight of all aspects of the research projects, and make informed decisions at critical junctures of the discovery pipeline. In close consultation with the NCI, the FCCC CAP-IT will leverage its unique resources and technical expertise to fuel the discovery of agents for cancer prevention and interception within the CAP-IT Network and beyond.