Cognitive Assessment and Adjudication Core

糖尿病预防的认知评估和裁定核心（认知核心）的目标 项目结果研究（DPPOS）阿尔茨海默病（AD）和AD相关痴呆（ADRD）项目是为了 进行与认知相关的所有培训、认证、质量保证（QA）和质量控制（QC）活动 测试和收集必要的数据，以测量认知能力下降，并定义轻度认知障碍的认知综合征。 认知障碍（MCI）和痴呆。此外，认知核心将与神经成像和 血浆生物标志物核心（生物标志物核心）和DPPOS临床操作和程序核心（临床 核心），以进一步将认知下降、MCI和痴呆分类为由于AD连续体、非AD病理性 变化，或血管对认知障碍和痴呆（VCID）的贡献，并与生物统计学和 数据基础设施核心（Data Core）用于分析认知数据及其解释。DPPOS包括 自2009年以来，西班牙语英语口语学习测试（SEVLT），数字符号替代测试（DSST）。和 自2015年以来，改良的简易精神状态检查（3 MS）。我们建议继续使用SEVLT、DSST和 3 MS在两个拟议的评估波，增加了全面的认知和功能测试，使用 国家阿尔茨海默病协调中心（NACC）统一数据集（UDS）表格的第三版。的 认知核心将通过以下目标实现其目标：（1）开发、维护、更新和实施 与认知和功能测试相关的培训、认证和QA程序，包括培训手册， 视频，以及SEVLT、DSST和3 MS的认证和再认证过程，NACC第3版- UDS认知、医生和功能评估;（2）制定和实施与以下相关的QC程序： 认知和功能测试，包括10%的测试表格和录音的集中检查 每季度进行一次所有测试，对DPPOS现场人员进行再培训和再认证， 通过电子邮件与专用核心进行真实的实时查询， （3）实施MCI、痴呆及其亚型诊断的裁定程序， 包括由有经验的认知判定者评估的认知和功能数据的汇总形式， 一个网站，用于分发摘要表格和由裁定者输入认知诊断，以及 裁定者之间分歧的解决过程;（4）进一步裁定MCI和痴呆为AD 在所有参与者中使用血浆ptau-181和淀粉样蛋白正电子发射的连续或非AD病理学 在接受脑成像的患者中进行PET扫描，探索使用脑血管数据裁定VCID 从MRI、临床脑成像和卒中史中，探索神经退行性疾病生物标志物的使用 和tau来定义tau和具有和不具有淀粉样蛋白阳性的神经变性;（5）协助数据核心， 分析所有项目的认知数据;（6）协助临床核心将认知诊断返回研究 参与者

The goal of the Cognitive Assessment and Adjudication Core (Cognition Core) of the Diabetes Prevention Program Outcomes Study (DPPOS) Alzheimer’s disease (AD) and AD related dementias (ADRD) project is to conduct all training, certification, quality assurance (QA) and quality control (QC) activities related to cognitive testing and collection of data necessary to measure cognitive decline and define the cognitive syndromes of mild cognitive impairment (MCI) and dementia. In addition, the Cognition Core will work with the Neuroimaging and Plasma Biomarkers core (Biomarkers Core) and the DPPOS Clinical Operations and Procedures Core (Clinical Core) to further classify cognitive decline, MCI, and dementia as due to AD continuum, non-AD pathologic change, or vascular contributions to cognitive impairment and dementia (VCID), and with the Biostatistics and Data Infrastructure Core (Data Core) in analyses of cognitive data and their interpretation. DPPOS has included the Spanish English Verbal Learning Test (SEVLT), the Digit Symbol Substitution Test (DSST), since 2009. And the Modified Mini-Mental Status Exam (3MS) since 2015. We propose to continue using the SEVLT, DSST, and 3MS in the two proposed assessment waves, adding comprehensive cognitive and functional testing using the third version of the National Alzheimer’s Coordinating Center (NACC) uniform dataset (UDS) forms. The cognition core will achieve its goal through the following aims: (1) To develop, maintain, update, and implement training, certification, and QA procedures related to cognitive and functional testing including training manuals, videos, and certification and recertification processes for the SEVLT, DSST, and 3MS, version 3 of the NACC- UDS cognitive, physician, and functional assessments; (2) To develop and implement QC procedures related to cognitive and functional testing including, central examination of testing forms and audio recordings from 10% of all tests administered on a quarterly basis, retraining and recertification of DPPOS site personnel as necessary, and continuous quality improvement through real time queries via email with a dedicated core manager; (3) To implement an adjudication procedure for the diagnoses of MCI, dementia, and their subtypes, including summary forms of cognitive and functional data to be evaluated by experienced cognitive adjudicators, a website for the distribution of the summary forms and entry of cognitive diagnoses by adjudicators, and a process for resolution of disagreements among adjudicators; (4) Further adjudicate MCI and dementia as AD continuum or non-AD pathology using plasma ptau-181 in all participants and amyloid positron emission tomography (PET) in those undergoing brain imaging, explore adjudicating VCID using cerebrovascular data from MRI, clinical brain imaging, and history of stroke, and explore the use of biomarkers of neurodegeneration and tau to define tau and neurodegeneration with and without amyloid positivity; (5) Assist the data core in the analyses of cognitive data for all projects; (6) Assist the Clinical Core in the return of cognitive diagnoses to study participants.