BDNF val66met Genotype and Age: Hurricane Sandy Supplement

BDNF val66met 基因型和年龄：飓风桑迪补充剂

• 批准号: 8744534
• 负责人: Terry Goldberg
• 金额: $ 14.62万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-12-20 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8744534
• 关键词: 11p13; Administrative Supplement; Affective; Age; Aging; Alleles; Area; Award; BDNF gene; Behavior; Behavioral; Biological; Biological Assay; Biological Markers; Brain; Brain-Derived Neurotrophic Factor; Budgets; Chromosomes; Cognition; County; Direct Costs; Docking; Electricity; Emotional; Enrollment; Episodic memory; Exercise; Floods; Frequencies; Funding; Funding Opportunities; Gasoline; Gene Expression Profiling; Genes; Genetic Polymorphism; Genetic Transcription; Genotype; Goals; Grant; Guidelines; Hippocampus (Brain); Homozygote; Human; Hurricane; Individual; Individual Differences; Institutes; Long Island; Magnetic Resonance Imaging; Manuscripts; Measures; Medial; Medical Research; Memory; Mental Depression; Methionine; Molecular; Neuroanatomy; Notification; Outcome; Pathway interactions; Pattern; Performance; Phase; Play; Postdoctoral Fellow; Procedures; Property; Protein Biosynthesis; Proteins; Publications; Recruitment Activity; Regulation; Research; Research Personnel; Role; Sampling; Schools; Specific qualifier value; Statistical Data Interpretation; Structure; Temporal Lobe; Testing; Time; TimeLine; Tissues; Transcript; Travel; United States National Institutes of Health; Valine; Variant; Vesicle; base; brain tissue; cost; experience; in vivo; interest; meetings; memory process; neurochemistry; neurocognitive test; postsynaptic; presynaptic; receptor; residence; response; risk variant; stem; trafficking

We are requesting a 24 month extension (as per the specific and stated RFA guidelines) of grant 1RO1AG038734 under the RFA-OD-13-199, NIH Administrative Supplement to Recover Losses due to Hurricane Sandy, the funded extension option. The first 12 months will be funded in Year 6 of our grant, and the next 12 months will be at no cost, as directly specified in the Funding Opportunity Purpose, point 1, and Award Budget of the RFA. We believe that we are eligible for this award due to the recruiting shortfall we experienced as a result of the hurricane. The additional time will be used to recruit, enroll, and assess subjects for Aim 2 of our grant and conduct statistical analyses of the data and prepare manuscripts for publication. The extension will be used to fund additional Research Assistant, Post Doctoral Fellow, Co-Investigator and PI time for these purposes. Importantly, funds will not be requested for direct subject procedures (neurocognitive testing, MRI, genotyping, assay costs), as these funds are already included in the original budget and overall subject numbers will not change. We are requesting $ 129,692 in direct costs. Nevertheless, we appreciate that this specified time period is perhaps rather ample for our needs. It could result in over-recruitment, though we would view this outcome very positively. We are requesting no other Hurricane Sandy related support. Our detailed rationale follows: Our Institute (Feinstein Institute for Medical Research) is on Long Island (Nassau County) which suffered major damage during Hurricane Sandy. During the hurricane and in the weeks following, there was a significant disruption to staffing and to our subject recruitment pool. Disruptions stemmed from loss of electricity (generally in the two week range), school cancellations (in some areas for up to several months), and to loss of residences due to flooding. Subjects suffered similar disruptions, as the majority of them also reside in Nassau County and western Suffolk County on Long Island. Further worsening this situation was a gasoline shortage that made travel nearly impossible for weeks. The region was slow to recover from the effects of the storm, and it took several months for participation in our research trials to rebound to previous levels. Further impacting our grant timeline was the recent notification from NIA (Ryan Blakeney, Aug 21, 2013) that our grant period will be shortened by an additional three months due to changes in the fiscal year.

我们请求将补助金延长24个月（根据RFA的具体和规定的指导方针） RFA-OD-13-199下的1 RO 1AG 038734，NIH行政补充，以恢复由于 飓风桑迪，资金延期选项。前12个月将在我们赠款的第6年资助， 接下来的12个月将是免费的，直接在资金机会目的第1点中指定， RFA的奖励预算。我们认为，我们有资格获得这一奖项，由于招聘短缺，我们 由于飓风的影响。额外的时间将用于招募、入组和评估受试者 为我们的资助目标2，并进行数据的统计分析和准备出版的手稿。 延期将用于资助额外的研究助理、博士后研究员、合作研究者和PI 时间为这些目的。重要的是，直接受试者程序（神经认知）不会要求资金 检测、MRI、基因分型、化验费用），因为这些资金已经包括在原始预算中， 受试者编号不变。我们要求129，692美元的直接费用。尽管如此，我们赞赏 这段时间也许足够满足我们的需要。但这可能会导致过度招聘 我们将非常积极地看待这一结果。 我们不要求其他与飓风桑迪有关的支持。我们的详细理由如下： 我们的研究所（范斯坦医学研究所）位于长岛（拿骚县）， 飓风桑迪造成的损失。在飓风期间和接下来的几周里， 人员配备和受试者招募库的中断。停电造成的中断 （一般在两周范围内），学校取消（在某些地区长达数月），以及失去 由于洪水，居民。受试者遭受了类似的干扰，因为他们中的大多数也居住在拿骚 长岛的萨福克县和西部。进一步恶化这种情况是汽油短缺 这使得几周内旅行几乎不可能。该地区从风暴的影响中恢复缓慢， 参与我们的研究试验的人数花了几个月的时间才恢复到以前的水平。 进一步影响我们的拨款时间轴的是NIA最近的通知（Ryan布莱克尼，2013年8月21日）， 由于财政年度的改变，我们的资助期将额外缩短三个月。