Research Methods Core: Cognitive Neuroscience

研究方法核心：认知神经科学

• 批准号: 8065455
• 负责人: Terry Goldberg
• 金额: $ 26.59万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8065455
• 关键词: Address; Adverse event; Antipsychotic Agents; Arts; Brain; Clinical; Controlled Clinical Trials; Data Analyses; Diffusion Magnetic Resonance Imaging; Dose; Drug Exposure; Feedback; Functional disorder; Generations; Goals; Growth; Individual; Intervention; Maps; Mediating; Methodology; Methods; Neurocognitive; Neurosciences Research; Outcome; Outcome Measure; Pathology; Patients; Positron-Emission Tomography; Rehabilitation therapy; Research Infrastructure; Research Methodology; Research Project Grants; Schizophrenia; Surface; Titrations; cognitive neuroscience; cohort; conventional therapy; effective intervention; effective therapy; functional outcomes; high standard; image processing; innovation; interest; investigator training; neurobiological mechanism; neuroimaging; neuropsychological; next generation; treatment response

The revolutionary growth of the cognitive neurosciences offers enormous promise for understanding the mechanisms underlying antipsychotic interventions. The overarching goal of the Research Methods Core is to support the application of state-of-the-art neurocognitive and neuroimaging methodologies that may help clarify the mechanisms underlying effective intervention in schizophrenia such as the prediction of treatment response, functional outcome, and adverse events in a unique cohort of first episode patients with minimal or no prior antipsychotic drug exposure. Compared to conventional treatment targets such as clinical symptomatology, cognitive neuroscience methods theoretically are more closely representative of brain dysfunction, and should ultimately be superior: (1) in classifying individuals who will benefit differentially from specific treatments, and some day, in the selection, dosing and titration of treatments; (2) in identifying the stable, enduring features of pathology that are most likely to predict distinctive outcomes, with implications for disposition and rehabilitative efforts; (3) in identifying neurobiological mechanisms that mediate treatment response with current, second-generation antipsychotics; and finally, (4) in serving as treatment targets themselves, possibly leading to the next generation of rationally-derived treatments. Moreover, information derived from cognitive neuroscience methods in well-controlled clinical trials will further provide crucial feedback to basic neuroscience research about the mechanisms underlying effective treatment. The Research Methods Core provides infrastructure support for the individual research projects, which include assessment of neurocognitive functioning, region-of-interest volumetric approaches, diffusion tensor imaging, cortical surface mapping and positron emission tomography to predict treatment response and multidimensional outcome measures. The specific aims of the Core include: (1) to integrate individual projects within the Center; (2) to develop innovative methods for data analysis and image processing; (3) to communicate findings and train investigators in neuropsychological and neuroimaging methods and (4) to maintain high standards of reliability for individual research projects. Mechanisms by which the Core accomplishes these aims will be addressed in turn, after a brief overview of the three major platforms for cognitive neuroscience research within the ZHH CIDAR.

认知神经科学的革命性发展为理解神经系统的功能提供了巨大的希望。 抗精神病药物干预的潜在机制。研究方法核心的总体目标是 支持最先进的神经认知和神经成像方法的应用， 阐明精神分裂症有效干预的机制，如治疗的预测 在一个独特的首次发作患者队列中， 没有服用过抗精神病药物与常规治疗目标相比， 认知神经科学的方法在理论上更能代表脑科学 功能障碍，并应最终是上级：（1）在分类的个人谁将受益于差异 具体的治疗，并有一天，在选择，剂量和滴定的治疗;（2）在确定 稳定的，持久的病理学特征，最有可能预测独特的结果， 用于处置和康复努力;（3）识别介导治疗的神经生物学机制 与当前的第二代抗精神病药的反应;最后，（4）作为治疗目标 可能导致下一代合理衍生的治疗方法。此外，信息 来自认知神经科学方法的良好对照临床试验将进一步提供关键的 反馈到基础神经科学研究中关于有效治疗的机制。的 研究方法核心为个别研究项目提供基础设施支持，包括 神经认知功能评估，感兴趣区容积法，弥散张量 成像、皮质表面映射和正电子发射断层扫描，以预测治疗反应， 多维度结果测量。核心的具体目标包括：（1）整合个人 （2）开发数据分析和图像处理的创新方法;（3） 交流研究结果，并对研究人员进行神经心理学和神经影像学方法的培训;（4） 保持高标准的可靠性为个别研究项目。核心小组通过何种机制 实现这些目标将依次讨论，在简要概述了三个主要平台， ZHH CIDAR中的认知神经科学研究。