A Study Implementing Models for Mechanical Circulatory Support Presurgical Assessment in Congenital Heart Disease Treatment (IMMPACT)
先天性心脏病治疗中机械循环支持术前评估模型的研究 (IMMPACT)
基本信息
- 批准号:10507509
- 负责人:
- 金额:$ 17.09万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-25 至 2027-07-31
- 项目状态:未结题
- 来源:
- 关键词:3-Dimensional3D PrintAdvisory CommitteesAffectAnatomic ModelsAnatomyAwardBlood CirculationCannulasCardiacCardiac OutputCardiopulmonary BypassCharacteristicsClinicalClinical DataCollectionCommon VentricleComplexCongenital AbnormalityControl GroupsDataData SetDevelopment PlansDiagnosisDiseaseEarly DiagnosisEnrollmentFontan ProcedureGoalsHeartHeart AbnormalitiesHeart TransplantationHeart failureHospitalsImageImaging TechniquesImaging technologyIntensive CareInterventionInvestigationInvestigative ReportsLearningLearning ModuleLesionLifeLife ExpectancyLongevityMagnetic Resonance ImagingMeasuresMedicalMedical centerMentorsMethodsModelingMorbidity - disease rateMulti-Institutional Clinical TrialMulticenter StudiesOperating RoomsOperative Surgical ProceduresOutcomeOutcome MeasurePatient CarePatient imagingPatient-Focused OutcomesPatientsPediatric cardiologyPediatricsPerioperativePhysiologyPopulationPositioning AttributePostoperative PeriodProceduresQuestionnairesRandomizedRandomized Controlled TrialsReportingResearchResearch MethodologyResearch PersonnelRight ventricular structureSecondary toSiteSurgeonSurveysTechniquesTimeTrainingUnited States National Institutes of HealthUniversitiesVisualizationWaiting ListsX-Ray Computed Tomographycareer developmentcongenital heart disorderdesigndisorder subtypeeffective therapyexperiencehigh riskhospital readmissionimaging modalityimplantable deviceimprovedimproved outcomeinnovative technologiesleft ventricular assist devicemalformationmechanical circulatory supportmortalitypalliatepatient oriented researchprimary outcomeprofessorprospectiveresearch data disseminationresponseroutine careskillsstandard of carethree-dimensional modelingtooltwo-dimensionalventricular assist device
项目摘要
Abstract
Kanwal M. Farooqi, MD is an Assistant Professor of Pediatrics in the Division of Pediatric Cardiology at Columbia
University Irving Medical Center. Her long term goal is to create a shift in what is considered standard of care in
advanced imaging for patients with complex congenital heart disease (CHD). Specifically, she aims to
demonstrate the utility and need for inclusion of personalized 3D printed models for pre-procedural planning in
patients with complex cardiac abnormalities. To that end, she will be focusing on patients with CHD and heart
failure (HF). Ventricular assist devices (VAD) in patients with CHD and HF remain underutilized, in part due to
the highly variable cardiac anatomy and complex physiology. This disparity exists despite outcomes following
VAD placement having been shown to be similar in patients with and without CHD. Imaging technologies such
as computed tomography (CT) or magnetic resonance imaging (MRI) are limiting in that they demonstrate
cardiac anatomy in 2D planes. 3D printed models allow the surgeon to visualize the cardiac anatomy in 3D as
they will see it in the operating room.
This is a prospective multicenter randomized control trial assessing the utility of preoperative use of 3D printed
personalized models use for VAD and cannula placement planning. The aims of this study are: 1) To assess if
3D printed cardiac models improve visualization of VAD and cannula placement sites in CHD-HF patients as
compared to 2D imaging. 2) To determine if perioperative factors and patient outcomes improve in CHD-HF
patients with use of 3D printed model in VAD placement planning. These aims will be accomplished through
implementation of surgical survey tools and collection of clinical data to assess improvement in outcomes.
Surgeons will report on survey tools, the ease with which important surgical landmarks such as cannula sites
are visualized on routine modes of imaging as compared to a 3D printed model. Clinical data will be compared
between the model and control group to assess improvement in clinical variables such as cardiopulmonary
bypass time and VAD flows. CUIMC is the primary site for this study with Dr. Farooqi as the primary investigator.
Dr. Farooqi’s career development plan consists of the following learning modules and training goals: 1) Training
in patient oriented research methods and multicenter study conduction 2) Surgical survey design and
implementation 3) Image acquisition and model creation methods 4) Research dissemination and career
Development. The co-mentoring and advisory team which she has organized will help her to acquire these skills
and successfully complete her learning goals through this award. Through completion of this study, Dr. Farooqi
aims to demonstrate the significance of 3D printed in pre-procedural planning for patients with complex CHD.
This will lead to an independent NIH proposal aiming to demonstrate the importance of incorporation of these
models across a wider range of congenital heart lesions and procedures, changing the way we think of standard
of care for advanced image modality inclusion in the care of patients with complex CHD.
摘要
坎瓦尔湾Farooqi医学博士是哥伦比亚大学儿科心脏病学分部的儿科助理教授
欧文大学医学中心。她的长期目标是改变人们所认为的护理标准,
复杂先天性心脏病(CHD)患者的先进成像技术。具体来说,她的目标是
证明在术前计划中纳入个性化3D打印模型的实用性和必要性,
患有复杂心脏异常的患者。为此,她将重点关注冠心病和心脏病患者,
故障(HF)。CHD和HF患者中的心室辅助装置(VAD)仍未得到充分利用,部分原因是
多变的心脏解剖结构和复杂的生理机能尽管结果如下,
已证明VAD放置在患有和不患有CHD的患者中是相似的。成像技术
因为计算机断层扫描(CT)或磁共振成像(MRI)是有限的,因为它们证明
2D平面中的心脏解剖结构。3D打印模型允许外科医生以3D方式可视化心脏解剖结构,
他们会在手术室里看到的
这是一项前瞻性多中心随机对照试验,评估术前使用3D打印的
用于VAD和插管放置规划的个性化模型。本研究的目的是:1)评估是否
3D打印心脏模型改善了CHD-HF患者的VAD和插管放置部位的可视化,
与2D成像相比。2)确定围手术期因素和患者结局是否改善CHD-HF
在VAD放置计划中使用3D打印模型的患者。这些目标将通过
实施手术调查工具和收集临床数据,以评估结果的改善。
外科医生将报告调查工具,重要的手术标志,如插管部位,
与3D打印模型相比,在常规成像模式下可视化。将比较临床数据
模型组和对照组之间的差异,以评估临床变量的改善,
旁路时间和VAD流量。CUIMC是本研究的主要研究中心,Farooqi博士是主要研究者。
博士Farooqi的职业发展计划包括以下学习模块和培训目标:1)培训
以患者为中心的研究方法和多中心研究的进行2)手术调查设计和
实施3)图像获取和模型创建方法4)研究传播和职业生涯
发展她组织的共同指导和咨询团队将帮助她获得这些技能
并通过这次获奖成功完成她的学习目标。通过完成本研究,Farooqi博士
旨在证明3D打印在复杂CHD患者术前计划中的重要性。
这将导致一个独立的国家卫生研究院的建议,旨在证明纳入这些重要性,
模型在更广泛的先天性心脏病病变和程序,改变了我们认为的标准
在复杂冠心病患者的护理中纳入先进的影像模式。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Kanwal Majeed Farooqi其他文献
Kanwal Majeed Farooqi的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
Study on the use of 3D print models to improve understanding of geomorphic processes
研究使用 3D 打印模型来提高对地貌过程的理解
- 批准号:
22K13777 - 财政年份:2022
- 资助金额:
$ 17.09万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
3D print-on-demand technology for personalised medicines at the point of care
用于护理点个性化药物的 3D 按需打印技术
- 批准号:
10045111 - 财政年份:2022
- 资助金额:
$ 17.09万 - 项目类别:
Grant for R&D
Regenerative cooling optimisation in 3D-print rocket nozzles
3D 打印火箭喷嘴的再生冷却优化
- 批准号:
2749141 - 财政年份:2022
- 资助金额:
$ 17.09万 - 项目类别:
Studentship
Development of a New Powder Mix and Process Plan to 3D Print Ductile Iron Parts
开发用于 3D 打印球墨铸铁零件的新粉末混合物和工艺计划
- 批准号:
548945-2019 - 财政年份:2021
- 资助金额:
$ 17.09万 - 项目类别:
College - University Idea to Innovation Grants
Development of a New Powder Mix and Process Plan to 3D Print Ductile Iron Parts
开发用于 3D 打印球墨铸铁零件的新粉末混合物和工艺计划
- 批准号:
548945-2019 - 财政年份:2020
- 资助金额:
$ 17.09万 - 项目类别:
College - University Idea to Innovation Grants
Administrative Supplement for Equipment: 6-axis Positioner to Improve 3D Print Quality and Print Size
设备管理补充:用于提高 3D 打印质量和打印尺寸的 6 轴定位器
- 批准号:
10801667 - 财政年份:2019
- 资助金额:
$ 17.09万 - 项目类别:
SBIR Phase II: Pellet based 3D print extrusion process for shoe manufacturing
SBIR 第二阶段:用于制鞋的基于颗粒的 3D 打印挤出工艺
- 批准号:
1738138 - 财政年份:2017
- 资助金额:
$ 17.09万 - 项目类别:
Standard Grant
Development of "artificial muscle' ink for 3D print of microrobots
开发用于微型机器人3D打印的“人造肌肉”墨水
- 批准号:
17K18852 - 财政年份:2017
- 资助金额:
$ 17.09万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
I-Corps: Nanochon, a Commercial Venture to 3D Print Regenerative Implants for Joint Reconstruction
I-Corps:Nanochon,一家商业企业,致力于 3D 打印再生植入物进行关节重建
- 批准号:
1612567 - 财政年份:2016
- 资助金额:
$ 17.09万 - 项目类别:
Standard Grant
SBIR Phase I: Pellet based 3D print extrusion process for shoe manufacturing
SBIR 第一阶段:用于制鞋的基于颗粒的 3D 打印挤出工艺
- 批准号:
1621732 - 财政年份:2016
- 资助金额:
$ 17.09万 - 项目类别:
Standard Grant