Transcranial focused ultrasound platform for noninvasive neuromodulation

用于无创神经调节的经颅聚焦超声平台

• 批准号: 10505912
• 负责人: Brian E Russ
• 金额: $ 45.22万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-10 至 2024-08-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10505912
• 关键词: 3-Dimensional; Acoustics; Alzheimer' s Disease; Behavior; Blood - brain barrier anatomy; Complement; Electric Stimulation; Focused Ultrasound; Funding; Human; Institutes; Magnetic Resonance Imaging; Magnetism; Major Depressive Disorder; Mental Health; Neuronavigation; Neurophysiology - biologic function; Post-Traumatic Stress Disorders; Recording of previous events; Request for Applications; Research; Research Project Grants; Resolution; Rest; S10 grant; Schizophrenia; System; Techniques; Technology; Testing; Therapeutic Effect; Time; Transcranial magnetic stimulation; Ultrasonics; biomedical imaging; instrument; instrumentation; neuroregulation; nonhuman primate; novel; optogenetics; receptor expression; relating to nervous system; translational neuroscience; ultrasound; vibration

Project Summary This S10 grant application requests funds to purchase a transcranial focused ultrasound (FUS) instrument platform for translational neuroscience studies in human and nonhuman primates. FUS is a means of non- invasively modulating neural activity, similar to transcranial magnetic stimulation (TMS) and electrical stimulation, through the application of ultrasonic acoustic vibrations, and can be implemented safely across a variety of species. Importantly, FUS has a number of important advantages over magnetic and electrical neuromodulation, including better spatial resolution (as small as .5 mm), and true three-dimensional targeting. Additionally, FUS technology has novel applications beyond direct stimulation, such as the ability to fenestrate the blood brain barrier for defined periods of time, with high spatial precision, opening new avenues for inducing noninvasive chemogenetic and optogenetic receptor expression. These strengths make FUS an ideal translational neuromodulatory technology for testing the causal relationship between neural functioning and behavior in a variety of species. Here we are requesting the funds to outfit the Center for Biomedical Imaging and Neuromodulation (C-BIN) at the Nathan Kline Institute with state-of-the-art, MRI compatible ultrasound instrumentation that is integrated with neuronavigation. This instrument system will complement our current TMS and transcranial electrical stimulation instruments. C-BIN has a long history of implementing novel neuroscientific techniques, and the integration of FUS would complement a number of mental health research projects that are ongoing and proposed within the institute. As a form of noninvasive neuromodulation, the proposed instruments would provide a benefit to current mental health research investigating the therapeutic effects of neuromodulation in major depressive disorder and Alzheimer’s Disease, schizophrenia, and post- traumatic stress disorder, and the neural underpinning of functional resting-state in nonhuman primates and humans. The addition of FUS as a translational neuromodulatory technique also opens the door to a large variety of new mental health related projects.

项目摘要 该S10赠款申请要求资金购买thrancranial专注的超声（FUS）仪器 人类和非人类隐私的转化神经科学研究平台。 FUS是一种非 - 侵入性调节神经元活性，类似于扭转磁刺激（TMS）和电气 通过应用超声声音振动的刺激，可以安全地实施 多种物种。重要的是，FUS与磁性和电气具有许多重要的优势 神经调节，包括更好的空间分辨率（小至0.5 mm）和真实的三维靶向。 此外，FUS技术还具有超出直接刺激的新颖应用，例如发声的能力 定义时期的血脑屏障，具有很高的空间精度，为 诱导非侵入性化学发生和光遗传受体表达。这些优势使FUS成为理想 转化神经调节技术，用于测试神经功能与神经功能的因果关系 各种物种的行为。在这里，我们要求资金适合生物医学成像中心 Nathan Kline Institute的神经调节（C-BIN）具有最先进的MRI兼容超声 仪器与神经统计的仪器。该仪器系统将完成我们的当前 TMS和Trancranial电气模拟仪器。 C-bin有悠久的实施小说的历史 神经科学技术以及FUS的整合将完成许多心理健康研究 研究所内正在进行并提出的项目。作为无创神经调节的一种形式， 拟议的仪器将为当前的心理健康研究提供好处 神经调节在重度抑郁症和阿尔茨海默氏病，精神分裂症和后 创伤性应激障碍，以及在非人类隐私和 人类。添加FUS作为翻译的神经调节技术也为大门打开了大门 各种新的与心理健康相关的项目。