Transcranial focused ultrasound platform for noninvasive neuromodulation

用于无创神经调节的经颅聚焦超声平台

• 批准号: 10505912
• 负责人: Brian E Russ
• 金额: $ 45.22万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-10 至 2024-08-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10505912
• 关键词: 3-Dimensional; Acoustics; Alzheimer' s Disease; Behavior; Blood - brain barrier anatomy; Complement; Electric Stimulation; Focused Ultrasound; Funding; Human; Institutes; Magnetic Resonance Imaging; Magnetism; Major Depressive Disorder; Mental Health; Neuronavigation; Neurophysiology - biologic function; Post-Traumatic Stress Disorders; Recording of previous events; Request for Applications; Research; Research Project Grants; Resolution; Rest; S10 grant; Schizophrenia; System; Techniques; Technology; Testing; Therapeutic Effect; Time; Transcranial magnetic stimulation; Ultrasonics; biomedical imaging; instrument; instrumentation; neuroregulation; nonhuman primate; novel; optogenetics; receptor expression; relating to nervous system; translational neuroscience; ultrasound; vibration

Project Summary This S10 grant application requests funds to purchase a transcranial focused ultrasound (FUS) instrument platform for translational neuroscience studies in human and nonhuman primates. FUS is a means of non- invasively modulating neural activity, similar to transcranial magnetic stimulation (TMS) and electrical stimulation, through the application of ultrasonic acoustic vibrations, and can be implemented safely across a variety of species. Importantly, FUS has a number of important advantages over magnetic and electrical neuromodulation, including better spatial resolution (as small as .5 mm), and true three-dimensional targeting. Additionally, FUS technology has novel applications beyond direct stimulation, such as the ability to fenestrate the blood brain barrier for defined periods of time, with high spatial precision, opening new avenues for inducing noninvasive chemogenetic and optogenetic receptor expression. These strengths make FUS an ideal translational neuromodulatory technology for testing the causal relationship between neural functioning and behavior in a variety of species. Here we are requesting the funds to outfit the Center for Biomedical Imaging and Neuromodulation (C-BIN) at the Nathan Kline Institute with state-of-the-art, MRI compatible ultrasound instrumentation that is integrated with neuronavigation. This instrument system will complement our current TMS and transcranial electrical stimulation instruments. C-BIN has a long history of implementing novel neuroscientific techniques, and the integration of FUS would complement a number of mental health research projects that are ongoing and proposed within the institute. As a form of noninvasive neuromodulation, the proposed instruments would provide a benefit to current mental health research investigating the therapeutic effects of neuromodulation in major depressive disorder and Alzheimer’s Disease, schizophrenia, and post- traumatic stress disorder, and the neural underpinning of functional resting-state in nonhuman primates and humans. The addition of FUS as a translational neuromodulatory technique also opens the door to a large variety of new mental health related projects.

项目摘要 这个S10助学金申请申请资金用于购买经颅聚焦超声(FUS)仪器 人类和非人类灵长类的翻译神经科学研究平台。FUS是一种非 侵入性调节神经活动，类似于经颅磁刺激(TMS)和电刺激 通过应用超声波声振进行刺激，并且可以安全地在 种类繁多。重要的是，与磁和电相比，FUS具有许多重要的优势 神经调节，包括更好的空间分辨率(小至0.5毫米)和真正的三维靶向。 此外，FUS技术在直接刺激之外还有新的应用，如开窗的能力 血脑屏障在规定的时间段内，具有高空间精度，为 诱导非侵入性的化学发生和光发生受体的表达。这些优势使FUS成为理想的选择 用于测试神经功能和神经功能之间因果关系的翻译神经调节技术 在各种物种中的行为。在这里，我们正在申请资金来装备生物医学成像中心 和神经调节(C-BIN)，在内森·克莱恩研究所使用最先进的磁共振兼容超声波 与神经导航相结合的仪器。这个仪器系统将补充我们目前的 TMS和经颅电刺激仪。C-BIN在实施新小说方面有很长的历史 神经科学技术，以及FUS的整合将补充一些精神健康研究 研究所内正在进行和提议的项目。作为非侵入性神经调节的一种形式， 建议的工具将为目前的心理健康研究提供好处，调查治疗 神经调节在重度抑郁障碍、阿尔茨海默病、精神分裂症和精神分裂症中的作用 创伤性应激障碍与非人类灵长类动物功能性静息状态的神经基础 人类。FUS的加入作为一种翻译神经调节技术也打开了一扇门， 各种与心理健康相关的新项目。