Processing of Communication Signals in Prefrontal Cortex

前额皮质通信信号的处理

• 批准号: 7290972
• 负责人: Brian E Russ
• 金额: $ 3.85万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-29 至 2008-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7290972
• 关键词: Auditory; Categories; Class; Code; Communication; Event; Facial Expression; Fire - disasters; Macaca mulatta; Modality; Neurons; Neurophysiology - biologic function; Play; Prefrontal Cortex; Process; Production; Property; Rate; Role; Signal Transduction; Stimulus; Testing; abstracting; base; neuromechanism; relating to nervous system; response; visual stimulus; vocalization

DESCRIPTION (provided by applicant): This proposal examines the role of the ventrolateral prefontal cortex (vPFC) in the processing of multimodal communication signals. In many cases, auditory and visual stimuli provide complementary information, and this especially true of communication signals. Rhesus macaques are sensitive to the correlations that exist between the production of vocalizations and the facial expressions that accompany them. Fundamental to the process of understanding multimodal stimuli is to combine both modalities into a unified representation. In Aim #1, we test the role of the vPFC in processing multimodal communication signals. We hypothesize that vPFC neurons respond preferentially to auditory and visual stimuli that convey complementary information. In Aim #2, we test the role of the vPFC in the categorization of multimodal communication signals. Rhesus monkeys discriminate between certain classes of species specific vocalizations based on relatively abstract categories as opposed to raw perceptual features, and this categorization can be seen in the firing rates of vPFC neurons. We hypothesize that vPFC neurons code multimodal stimuli into categories that are based on the information they convey as opposed to their morphological properties.

描述（由申请人提供）：该提案研究了腹外侧外皮层（VPFC）在多模式通信信号处理中的作用。在许多情况下，听觉和视觉刺激提供了互补的信息，而沟通信号尤其如此。恒河猕猴对发声的产生与伴随的面部表情之间存在的相关性很敏感。理解多模式刺激过程的基础是将这两种模式结合成统一的表示。在AIM＃1中，我们测试了VPFC在处理多模式通信信号中的作用。我们假设VPFC神经元对传达互补信息的听觉和视觉刺激的反应优先响应。在AIM＃2中，我们测试了VPFC在多模式通信信号分类中的作用。恒河猴会根据相对抽象的类别而不是原始感知特征区分某些类别的物种特定的发声，并且在VPFC神经元的触发速率中可以看到这种分类。我们假设VPFC神经元将多模式刺激编码为基于它们传达的信息而不是形态学特性的类别。