Duke Center for HIV Structural Biology
杜克大学艾滋病毒结构生物学中心
基本信息
- 批准号:10506661
- 负责人:
- 金额:$ 550.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-14 至 2027-03-31
- 项目状态:未结题
- 来源:
- 关键词:AIDS/HIV problemAcquired Immunodeficiency SyndromeAdherenceAntibodiesAutologousB-Cell ActivationB-Cell Antigen ReceptorB-LymphocytesBehaviorBiologyCell membraneCellsChronic DiseaseClinical ManagementClonal ExpansionComplexDevelopmentDiseaseDisease remissionEconomic BurdenElementsEpitopesEvolutionFab ImmunoglobulinsGlycoproteinsGoalsHIVHIV Envelope Protein gp120HIV InfectionsHIV-1ImmuneImmune responseImmune systemImmunobiologyImmunoglobulin Somatic HypermutationIndividualInfectionKineticsKnowledgeMediatingMembraneMethodsMolecular ConformationMovementOutcomePathway interactionsPeptidesPersonsPlayProcessProvirusesReceptor ActivationReceptor SignalingResearchResearch PersonnelResolutionResourcesRoleSeriesSignal PathwaySignal TransductionSpecificityStructureSurfaceTechniquesTherapeuticTimeVaccinationVaccinesViralViral reservoirViremiaVirusantiretroviral therapyatomic interactionscareerglobal healthimmune activationinnovationinsightlatent HIV reservoirmolecular dynamicsmultilevel analysisneutralizing antibodynew therapeutic targetpandemic diseasepreventreceptorreceptor bindingresistance mechanismresponsestructural biologytemporal measurementtherapeutic targettraining opportunityvaccine developmentvaccine responsevaccine trialviral rebound
项目摘要
Abstract – Overall
Approximately 40 million people worldwide are living with HIV/AIDS; however, a protective vaccine or
functional cure remain elusive despite four decades of intense research. HIV-1 evades the immune system
through its rapid structural evolution during infection and replication. The proposed Duke Center for HIV
Structural Biology will provide new insights into the dynamics of HIV-1 entry and fusion with the host
membrane, the Env-initiated immune activation of B-cell receptors, and the role of anti-Env antibodies in
blocking viral rebound. The Center will pursue structural studies that aim to 1) to develop a complete, time
resolved and atomically detailed mechanism of HIV-1 Env fusion; 2) to define BCR complex structures with
specificity of autologous (anAb) and broadly neutralizing antibodies (bnAb); and 3) to achieve an atomic level
understanding of antibody-mediated control of rebound from latent HIV-1 reservoirs. The ultimate goal of these
studies is to advance structural biology techniques and knowledge of HIV-1 Env structure-derived disease
mechanisms in HIV-1 infection and rebound. Additionally, through its Developmental Core, the Center will
provide resources and training opportunities for early career investigators and trainees who are pursuing
careers in the field of HIV-1 structural biology.
摘要--总体
全世界约有4000万人感染艾滋病毒/艾滋病;然而,保护性疫苗或
尽管进行了40年的紧张研究,但功能性治愈仍然难以捉摸。HIV-1逃避免疫系统
通过其在感染和复制过程中的快速结构演变。拟建的杜克艾滋病毒中心
结构生物学将为HIV-1进入和与宿主融合的动态提供新的见解
膜、Env启动的B细胞受体免疫激活以及抗Env抗体在血管内皮细胞瘤中的作用
阻止病毒反弹。该中心将进行结构研究,旨在1)开发一个完整的,时间
解析和原子详细的HIV-1 env融合机制;2)确定BCR复杂结构
自身抗体(Anab)和广谱中和抗体(BNab)的特异性;以及3)达到原子水平
了解抗体介导的控制潜伏的HIV-1储备库的反弹。这些项目的最终目标是
研究是推进HIV-1环境结构衍生疾病的结构生物学技术和知识
HIV-1感染和反弹的机制。此外,通过其发展核心,该中心将
为从事早期职业研究的人员和实习生提供资源和培训机会
HIV-1结构生物学领域的职业。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Priyamvada Acharya其他文献
Priyamvada Acharya的其他文献
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{{ truncateString('Priyamvada Acharya', 18)}}的其他基金
Effect of natural and engineered variations on structure and biophysics of SARS-CoV-2 spike
自然和工程变异对 SARS-CoV-2 刺突结构和生物物理学的影响
- 批准号:
10558637 - 财政年份:2022
- 资助金额:
$ 550.51万 - 项目类别:
Project 3 - Dynamics of latent HIV-1 reservoirs: High resolution antigenic mapping and strategies to block rebound
项目 3 - 潜在 HIV-1 储存库的动态:高分辨率抗原图谱和阻止反弹的策略
- 批准号:
10506669 - 财政年份:2022
- 资助金额:
$ 550.51万 - 项目类别:
Dissecting the mechanisms of HIV resistance in vivo to broadly neutralizing antibodies
剖析 HIV 体内对广泛中和抗体的耐药机制
- 批准号:
10458981 - 财政年份:2022
- 资助金额:
$ 550.51万 - 项目类别:
Dissecting the mechanisms of HIV resistance in vivo to broadly neutralizing antibodies
剖析 HIV 体内对广泛中和抗体的耐药机制
- 批准号:
10680388 - 财政年份:2022
- 资助金额:
$ 550.51万 - 项目类别:
Effect of natural and engineered variations on structure and biophysics of SARS-CoV-2 spike
自然和工程变异对 SARS-CoV-2 刺突结构和生物物理学的影响
- 批准号:
10453964 - 财政年份:2022
- 资助金额:
$ 550.51万 - 项目类别:
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