Duke Center for HIV Structural Biology

杜克大学艾滋病毒结构生物学中心

• 批准号: 10506661
• 负责人: Priyamvada Acharya
• 金额: $ 550.51万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-14 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10506661
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adherence; Antibodies; Autologous; B-Cell Activation; B-Cell Antigen Receptor; B-Lymphocytes; Behavior; Biology; Cell membrane; Cells; Chronic Disease; Clinical Management; Clonal Expansion; Complex; Development; Disease; Disease remission; Economic Burden; Elements; Epitopes; Evolution; Fab Immunoglobulins; Glycoproteins; Goals; HIV; HIV Envelope Protein gp120; HIV Infections; HIV-1; Immune; Immune response; Immune system; Immunobiology; Immunoglobulin Somatic Hypermutation; Individual; Infection; Kinetics; Knowledge; Mediating; Membrane; Methods; Molecular Conformation; Movement; Outcome; Pathway interactions; Peptides; Persons; Play; Process; Proviruses; Receptor Activation; Receptor Signaling; Research; Research Personnel; Resolution; Resources; Role; Series; Signal Pathway; Signal Transduction; Specificity; Structure; Surface; Techniques; Therapeutic; Time; Vaccination; Vaccines; Viral; Viral reservoir; Viremia; Virus; antiretroviral therapy; atomic interactions; career; global health; immune activation; innovation; insight; latent HIV reservoir; molecular dynamics; multilevel analysis; neutralizing antibody; new therapeutic target; pandemic disease; prevent; receptor; receptor binding; resistance mechanism; response; structural biology; temporal measurement; therapeutic target; training opportunity; vaccine development; vaccine response; vaccine trial; viral rebound

Abstract – Overall Approximately 40 million people worldwide are living with HIV/AIDS; however, a protective vaccine or functional cure remain elusive despite four decades of intense research. HIV-1 evades the immune system through its rapid structural evolution during infection and replication. The proposed Duke Center for HIV Structural Biology will provide new insights into the dynamics of HIV-1 entry and fusion with the host membrane, the Env-initiated immune activation of B-cell receptors, and the role of anti-Env antibodies in blocking viral rebound. The Center will pursue structural studies that aim to 1) to develop a complete, time resolved and atomically detailed mechanism of HIV-1 Env fusion; 2) to define BCR complex structures with specificity of autologous (anAb) and broadly neutralizing antibodies (bnAb); and 3) to achieve an atomic level understanding of antibody-mediated control of rebound from latent HIV-1 reservoirs. The ultimate goal of these studies is to advance structural biology techniques and knowledge of HIV-1 Env structure-derived disease mechanisms in HIV-1 infection and rebound. Additionally, through its Developmental Core, the Center will provide resources and training opportunities for early career investigators and trainees who are pursuing careers in the field of HIV-1 structural biology.

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