Duke Center for HIV Structural Biology
杜克大学艾滋病毒结构生物学中心
基本信息
- 批准号:10506661
- 负责人:
- 金额:$ 550.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-14 至 2027-03-31
- 项目状态:未结题
- 来源:
- 关键词:AIDS/HIV problemAcquired Immunodeficiency SyndromeAdherenceAntibodiesAutologousB-Cell ActivationB-Cell Antigen ReceptorB-LymphocytesBehaviorBiologyCell membraneCellsChronic DiseaseClinical ManagementClonal ExpansionComplexDevelopmentDiseaseDisease remissionEconomic BurdenElementsEpitopesEvolutionFab ImmunoglobulinsGlycoproteinsGoalsHIVHIV Envelope Protein gp120HIV InfectionsHIV-1ImmuneImmune responseImmune systemImmunobiologyImmunoglobulin Somatic HypermutationIndividualInfectionKineticsKnowledgeMediatingMembraneMethodsMolecular ConformationMovementOutcomePathway interactionsPeptidesPersonsPlayProcessProvirusesReceptor ActivationReceptor SignalingResearchResearch PersonnelResolutionResourcesRoleSeriesSignal PathwaySignal TransductionSpecificityStructureSurfaceTechniquesTherapeuticTimeVaccinationVaccinesViralViral reservoirViremiaVirusantiretroviral therapyatomic interactionscareerglobal healthimmune activationinnovationinsightlatent HIV reservoirmolecular dynamicsmultilevel analysisneutralizing antibodynew therapeutic targetpandemic diseasepreventreceptorreceptor bindingresistance mechanismresponsestructural biologytemporal measurementtherapeutic targettraining opportunityvaccine developmentvaccine responsevaccine trialviral rebound
项目摘要
Abstract – Overall
Approximately 40 million people worldwide are living with HIV/AIDS; however, a protective vaccine or
functional cure remain elusive despite four decades of intense research. HIV-1 evades the immune system
through its rapid structural evolution during infection and replication. The proposed Duke Center for HIV
Structural Biology will provide new insights into the dynamics of HIV-1 entry and fusion with the host
membrane, the Env-initiated immune activation of B-cell receptors, and the role of anti-Env antibodies in
blocking viral rebound. The Center will pursue structural studies that aim to 1) to develop a complete, time
resolved and atomically detailed mechanism of HIV-1 Env fusion; 2) to define BCR complex structures with
specificity of autologous (anAb) and broadly neutralizing antibodies (bnAb); and 3) to achieve an atomic level
understanding of antibody-mediated control of rebound from latent HIV-1 reservoirs. The ultimate goal of these
studies is to advance structural biology techniques and knowledge of HIV-1 Env structure-derived disease
mechanisms in HIV-1 infection and rebound. Additionally, through its Developmental Core, the Center will
provide resources and training opportunities for early career investigators and trainees who are pursuing
careers in the field of HIV-1 structural biology.
摘要-总体
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Priyamvada Acharya其他文献
Priyamvada Acharya的其他文献
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{{ truncateString('Priyamvada Acharya', 18)}}的其他基金
Effect of natural and engineered variations on structure and biophysics of SARS-CoV-2 spike
自然和工程变异对 SARS-CoV-2 刺突结构和生物物理学的影响
- 批准号:
10558637 - 财政年份:2022
- 资助金额:
$ 550.51万 - 项目类别:
Project 3 - Dynamics of latent HIV-1 reservoirs: High resolution antigenic mapping and strategies to block rebound
项目 3 - 潜在 HIV-1 储存库的动态:高分辨率抗原图谱和阻止反弹的策略
- 批准号:
10506669 - 财政年份:2022
- 资助金额:
$ 550.51万 - 项目类别:
Dissecting the mechanisms of HIV resistance in vivo to broadly neutralizing antibodies
剖析 HIV 体内对广泛中和抗体的耐药机制
- 批准号:
10458981 - 财政年份:2022
- 资助金额:
$ 550.51万 - 项目类别:
Dissecting the mechanisms of HIV resistance in vivo to broadly neutralizing antibodies
剖析 HIV 体内对广泛中和抗体的耐药机制
- 批准号:
10680388 - 财政年份:2022
- 资助金额:
$ 550.51万 - 项目类别:
Effect of natural and engineered variations on structure and biophysics of SARS-CoV-2 spike
自然和工程变异对 SARS-CoV-2 刺突结构和生物物理学的影响
- 批准号:
10453964 - 财政年份:2022
- 资助金额:
$ 550.51万 - 项目类别:
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3554155 - 财政年份:1991
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3554156 - 财政年份:1991
- 资助金额:
$ 550.51万 - 项目类别:
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