Core 1 - Structural Biology Core

核心 1 - 结构生物学核心

基本信息

  • 批准号:
    10643911
  • 负责人:
  • 金额:
    $ 111.15万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-06-14 至 2027-03-31
  • 项目状态:
    未结题

项目摘要

Abstract – Core 1 – Structural Biology Core Approximately 40 million people worldwide are living with HIV/AIDS; however, a protective vaccine or functional cure remain elusive despite four decades of intense research. HIV-1 evades the immune system through its rapid structural evolution during infection and replication. The Duke Center for HIV Structural Biology will pursue structural studies of the evolution of the HIV-1 Envelope (Env) protein to elucidate structure-function mechanisms for viral entry, B-cell and T-cell activation, and viral rebound after antiretroviral therapy ART. The Structural Biology Core (Core 1) will support the overall mission of the Center by establishing a state-of-the-art pipeline for structural analysis of HIV-1 Env using a wide range of experimental techniques. The Core will provide access to cutting-edge techniques for structure determination and have a strong component of technology development that will ultimately advance our mechanistic understanding of Env. The research projects will benefit from having access to established protocols for structure determination as well as new methods resulting from the technology development efforts of the core. The Specific Aims of the Structural Biology Core are 1) to establish a high- throughput pipeline for routine characterization of the structure and dynamics of soluble HIV-1 trimers using high- resolution single-particle cryo-EM; 2) to develop advanced workflows for structural analysis of native HIV-1 samples imaged in-situ using cryo-electron tomography (ET) at near-atomic resolution; and 3) to establish structural methods for microsecond time resolution structural studies of HIV-1 Env. Completion of the three proposed aims will provide a solid infrastructure in structural biology needed to support the overall goals of the Center and its components. By providing access to state-of-the-art technology for the determination of structures of HIV-1 at the highest possible spatial and temporal resolution, will provide unique opportunities for visualizing key intermediates that could inform our understanding of HIV viral infection. The ability to determine high-resolution structures of soluble or native forms of Env will be critical to improve our understanding of HIV. The technologies developed as part of the Structural Biology Core will have implications beyond the field of HIV and would benefit structural studies of other biological systems. By making our tools available to the structural biology community, the activities of the core will have an even wider impact.
摘要-核心1 -结构生物学核心

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Priyamvada Acharya其他文献

Priyamvada Acharya的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Priyamvada Acharya', 18)}}的其他基金

Effect of natural and engineered variations on structure and biophysics of SARS-CoV-2 spike
自然和工程变异对 SARS-CoV-2 刺突结构和生物物理学的影响
  • 批准号:
    10558637
  • 财政年份:
    2022
  • 资助金额:
    $ 111.15万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10643907
  • 财政年份:
    2022
  • 资助金额:
    $ 111.15万
  • 项目类别:
Project 3 - Dynamics of latent HIV-1 reservoirs: High resolution antigenic mapping and strategies to block rebound
项目 3 - 潜在 HIV-1 储存库的动态:高分辨率抗原图谱和阻止反弹的策略
  • 批准号:
    10506669
  • 财政年份:
    2022
  • 资助金额:
    $ 111.15万
  • 项目类别:
Duke Center for HIV Structural Biology
杜克大学艾滋病毒结构生物学中心
  • 批准号:
    10643906
  • 财政年份:
    2022
  • 资助金额:
    $ 111.15万
  • 项目类别:
Core 1 - Structural Biology Core
核心 1 - 结构生物学核心
  • 批准号:
    10506664
  • 财政年份:
    2022
  • 资助金额:
    $ 111.15万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10506662
  • 财政年份:
    2022
  • 资助金额:
    $ 111.15万
  • 项目类别:
Dissecting the mechanisms of HIV resistance in vivo to broadly neutralizing antibodies
剖析 HIV 体内对广泛中和抗体的耐药机制
  • 批准号:
    10458981
  • 财政年份:
    2022
  • 资助金额:
    $ 111.15万
  • 项目类别:
Duke Center for HIV Structural Biology
杜克大学艾滋病毒结构生物学中心
  • 批准号:
    10506661
  • 财政年份:
    2022
  • 资助金额:
    $ 111.15万
  • 项目类别:
Dissecting the mechanisms of HIV resistance in vivo to broadly neutralizing antibodies
剖析 HIV 体内对广泛中和抗体的耐药机制
  • 批准号:
    10680388
  • 财政年份:
    2022
  • 资助金额:
    $ 111.15万
  • 项目类别:
Effect of natural and engineered variations on structure and biophysics of SARS-CoV-2 spike
自然和工程变异对 SARS-CoV-2 刺突结构和生物物理学的影响
  • 批准号:
    10453964
  • 财政年份:
    2022
  • 资助金额:
    $ 111.15万
  • 项目类别:

相似海外基金

RII Track-1: Interface of Change: Building Collaborations to Assess Harvested and Farmed Marine Species Prioritized by Gulf of Alaska Communities Facing Environmental Shifts
RII Track-1:变革界面:建立合作来评估面临环境变化的阿拉斯加湾社区优先考虑的捕捞和养殖海洋物种
  • 批准号:
    2344553
  • 财政年份:
    2024
  • 资助金额:
    $ 111.15万
  • 项目类别:
    Cooperative Agreement
Conference: Global Bioinformatics Education Summit 2024 — Energizing Communities to Power the Bioeconomy Workforce
会议:2024 年全球生物信息学教育峰会 — 激励社区为生物经济劳动力提供动力
  • 批准号:
    2421267
  • 财政年份:
    2024
  • 资助金额:
    $ 111.15万
  • 项目类别:
    Standard Grant
CAREER: Evaluating Cooperative Intelligence in Connected Communities
职业:评估互联社区中的合作智能
  • 批准号:
    2339497
  • 财政年份:
    2024
  • 资助金额:
    $ 111.15万
  • 项目类别:
    Continuing Grant
Improving Resilience of MCDI for Water Supply in Remote Communities
提高偏远社区供水的 MCDI 弹性
  • 批准号:
    DP240101469
  • 财政年份:
    2024
  • 资助金额:
    $ 111.15万
  • 项目类别:
    Discovery Projects
Reconnecting Warlpiri communities with cultural heritage materials
重新连接瓦尔皮里社区与文化遗产材料
  • 批准号:
    LP220200211
  • 财政年份:
    2024
  • 资助金额:
    $ 111.15万
  • 项目类别:
    Linkage Projects
Creating cosmopolitan rural communities through Japanese crafts: a comparative perspective with Portugal and Brazil
通过日本手工艺创建国际化农村社区:与葡萄牙和巴西的比较视角
  • 批准号:
    24K21000
  • 财政年份:
    2024
  • 资助金额:
    $ 111.15万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Understanding Material Interactions and Effects on Polymicrobial Communities at Surfaces
了解材料相互作用和对表面多种微生物群落的影响
  • 批准号:
    BB/Y512412/1
  • 财政年份:
    2024
  • 资助金额:
    $ 111.15万
  • 项目类别:
    Training Grant
An interdisciplinary analytical framework for high-mountain landslides and cascading hazards: implications for communities and infrastructure
高山滑坡和级联灾害的跨学科分析框架:对社区和基础设施的影响
  • 批准号:
    NE/Z503502/1
  • 财政年份:
    2024
  • 资助金额:
    $ 111.15万
  • 项目类别:
    Research Grant
Doctoral Dissertation Research: Spatial and Geological Mapping in Local Communities
博士论文研究:当地社区的空间和地质测绘
  • 批准号:
    2342887
  • 财政年份:
    2024
  • 资助金额:
    $ 111.15万
  • 项目类别:
    Standard Grant
Building Capacity through Professional Learning Communities to Advance Identity Integration in STEM Pre-Service Teacher Preparation
通过专业学习社区进行能力建设,促进 STEM 职前教师准备中的身份整合
  • 批准号:
    2345042
  • 财政年份:
    2024
  • 资助金额:
    $ 111.15万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了