The Impact of Environmental Stressors on Chronic Disease Disparities in Women

环境压力因素对女性慢性病差异的影响

• 批准号: 10517205
• 负责人: NICOLE R NUGENT
• 金额: $ 63.42万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10517205
• 关键词: Impact; Environmental; Stressors; Chronic; Disease

Project Summary The overall objective of this project is to determine the impact of social stressors on epigenetic age acceleration and chronic health disparities and to test whether the social environment, individual health behaviors, and race/geography/SES modify or mediate the association between traumatic stress and health (disparities), directly or indirectly through biologic age acceleration. We expect that the trauma burden will impact chronic diseases through DNA methylation (DNAm) age acceleration. The WaTCH cohort is an important, highly trauma- exposed sample of women uniquely poised for a third wave of data collection that continues assessing trauma exposure, depression, PTSD, social context, physical health, and collection of an additional blood specimen eight years after the baseline to examine of DNAm age. Aim 1 will investigate disparities in psychological health (PTSD, depression), physical health (diabetes, hypertension, and cancer), and DNAm age acceleration as women age, particularly as influenced by cumulative trauma burden. Aim 2 will examine the influences of contextual variables, including social capital and financial strain, that may mediate or moderate the effects of cumulative trauma burden on adverse psychological and physical health outcomes. Aim 3 will explore the mediating effects of DNAm age acceleration on physical and mental health outcomes. The proposed study will use the WaTCH cohort of 2800 women exposed to the Deepwater Horizon Oil Spill in coastal Louisiana in 2010. It will entail the third wave of data and biospecimen collection and incorporate data already gathered through two previous waves of data collection. Self-reported health data on demographic, income and financial stressors, oil spill exposure, neighborhood context, social capital, health behaviors, trauma history, psychological symptoms, and physical health will be collected through telephone interviews. Repeat blood samples will be collected from up to 1058 women with baseline samples.

项目摘要 这个项目的总体目标是确定社会压力对表观遗传的影响。 年龄加速和慢性健康差异，并测试社会环境， 个人健康行为和种族/地理/社会经济地位改变或介导了这种关联 创伤压力和健康之间的差异，直接或间接通过生物年龄 加速度我们预计创伤负担将通过DNA影响慢性疾病 DNA甲基化（DNAm）加速衰老。WaTCH队列是一个重要的，高度创伤- 暴露的妇女样本独特地准备为第三波数据收集，继续 评估创伤暴露，抑郁症，PTSD，社会背景，身体健康，以及收集 基线后8年的额外血液样本，以检查DNA年龄。目标1将 调查心理健康（创伤后应激障碍，抑郁症），身体健康（糖尿病， 高血压和癌症），以及随着女性年龄的增长，特别是 受到累积创伤负担的影响。目标2将考察语境的影响 变量，包括社会资本和财政紧张，可能介导或缓和的影响， 累积创伤负担对不良心理和身体健康结果的影响。目标3将 探讨DNA年龄加速对身心健康的中介作用 结果。 拟议的研究将使用2800名暴露于深水的妇女的WaTCH队列 2010年路易斯安那州沿海的地平线石油泄漏。这将带来第三波数据， 生物标本收集和合并已经通过前两波收集的数据， 数据收集。自我报告的关于人口、收入和财务压力因素的健康数据，石油 泄漏暴露，邻里环境，社会资本，健康行为，创伤史， 心理症状和身体健康状况将通过电话访问收集。 将从多达1058名具有基线样本的女性中重复采集血液样本。