The Impact of Environmental Stressors on Chronic Disease Disparities in Women

项目概要 该项目的总体目标是确定社会压力源对表观遗传的影响 年龄加速和长期健康差异，并测试社会环境是否， 个人健康行为、种族/地理/社会经济地位会改变或调节这种关联 创伤应激与健康之间（差异），直接或间接地通过生物年龄 加速度。我们预计创伤负担将通过 DNA 影响慢性疾病 甲基化（DNAm）年龄加速。 WatchCH 队列是一个重要的、高度创伤的群体 暴露的女性样本独特地准备好继续进行第三波数据收集 评估创伤暴露、抑郁、创伤后应激障碍、社会背景、身体健康以及收集 基线八年后额外采集一份血液样本以检查 DNAm 年龄。目标1将 调查心理健康（创伤后应激障碍、抑郁症）、身体健康（糖尿病、 高血压和癌症），以及 DNAm 年龄随着女性年龄的增长而加速，特别是 受累积创伤负担的影响。目标 2 将检验情境的影响 可能调节或缓和影响的变量，包括社会资本和财务压力 累积创伤负担对不良心理和身体健康结果的影响。目标3将 探讨DNAm年龄加速对身心健康的中介作用 结果。 拟议的研究将使用由 2800 名暴露于深水的女性组成的 WatchCH 队列 2010 年路易斯安那州沿海发生地平线漏油事件。这将带来第三波数据和 生物样本收集并合并通过前两波已经收集的数据 数据收集。关于人口、收入和财务压力因素、石油的自我报告健康数据 泄漏暴露、邻里环境、社会资本、健康行为、创伤史、 心理症状和身体健康状况将通过电话访谈收集。 将从多达 1058 名具有基线样本的女性中采集重复血样。

Project Summary The overall objective of this project is to determine the impact of social stressors on epigenetic age acceleration and chronic health disparities and to test whether the social environment, individual health behaviors, and race/geography/SES modify or mediate the association between traumatic stress and health (disparities), directly or indirectly through biologic age acceleration. We expect that the trauma burden will impact chronic diseases through DNA methylation (DNAm) age acceleration. The WaTCH cohort is an important, highly trauma- exposed sample of women uniquely poised for a third wave of data collection that continues assessing trauma exposure, depression, PTSD, social context, physical health, and collection of an additional blood specimen eight years after the baseline to examine of DNAm age. Aim 1 will investigate disparities in psychological health (PTSD, depression), physical health (diabetes, hypertension, and cancer), and DNAm age acceleration as women age, particularly as influenced by cumulative trauma burden. Aim 2 will examine the influences of contextual variables, including social capital and financial strain, that may mediate or moderate the effects of cumulative trauma burden on adverse psychological and physical health outcomes. Aim 3 will explore the mediating effects of DNAm age acceleration on physical and mental health outcomes. The proposed study will use the WaTCH cohort of 2800 women exposed to the Deepwater Horizon Oil Spill in coastal Louisiana in 2010. It will entail the third wave of data and biospecimen collection and incorporate data already gathered through two previous waves of data collection. Self-reported health data on demographic, income and financial stressors, oil spill exposure, neighborhood context, social capital, health behaviors, trauma history, psychological symptoms, and physical health will be collected through telephone interviews. Repeat blood samples will be collected from up to 1058 women with baseline samples.