The Impact of Environmental Stressors on Chronic Disease Disparities in Women

项目摘要 该项目的总体目标是确定社会应激源对表观遗传学的影响。 年龄加速和慢性健康差距，并测试社会环境， 个人健康行为和种族/地理/社会经济状况改变或调节这种联系 创伤应激与健康之间的差异，直接或间接地通过生物年龄 加速。我们预计创伤负担将通过DNA影响慢性疾病 甲基化(DNaM)年龄加速。值班队伍是一个重要的，高度的创伤- 暴露的女性样本为继续进行的第三波数据收集做好了独特的准备 评估创伤暴露、抑郁、创伤后应激障碍、社会背景、身体健康和收集 基线后8年再取一份血样，以检测dNaM年龄。目标1将 调查心理健康(创伤后应激障碍、抑郁)、身体健康(糖尿病、 高血压和癌症)，以及随着女性年龄的增长而加速的dNaM年龄，特别是在 受累积创伤负担的影响。目标2将考察语境的影响 可能调解或缓和影响的变量，包括社会资本和财政压力 累积创伤负担对不利的心理和身体健康结果的影响。目标3将 探讨dNaM年龄加速对身心健康的中介作用 结果。 这项拟议的研究将使用2800名接触深水的女性的观察队列 2010年路易斯安那州沿海的地平线漏油事件。这将带来第三波数据和 Biosecimen收集和整合已经通过前两波 数据收集。关于人口、收入和财务压力来源的自我报告的健康数据，石油 泄漏暴露，邻里环境，社会资本，健康行为，创伤史， 将通过电话采访收集心理症状和身体健康情况。 将从多达1058名具有基线样本的妇女身上收集重复血液样本。

Project Summary The overall objective of this project is to determine the impact of social stressors on epigenetic age acceleration and chronic health disparities and to test whether the social environment, individual health behaviors, and race/geography/SES modify or mediate the association between traumatic stress and health (disparities), directly or indirectly through biologic age acceleration. We expect that the trauma burden will impact chronic diseases through DNA methylation (DNAm) age acceleration. The WaTCH cohort is an important, highly trauma- exposed sample of women uniquely poised for a third wave of data collection that continues assessing trauma exposure, depression, PTSD, social context, physical health, and collection of an additional blood specimen eight years after the baseline to examine of DNAm age. Aim 1 will investigate disparities in psychological health (PTSD, depression), physical health (diabetes, hypertension, and cancer), and DNAm age acceleration as women age, particularly as influenced by cumulative trauma burden. Aim 2 will examine the influences of contextual variables, including social capital and financial strain, that may mediate or moderate the effects of cumulative trauma burden on adverse psychological and physical health outcomes. Aim 3 will explore the mediating effects of DNAm age acceleration on physical and mental health outcomes. The proposed study will use the WaTCH cohort of 2800 women exposed to the Deepwater Horizon Oil Spill in coastal Louisiana in 2010. It will entail the third wave of data and biospecimen collection and incorporate data already gathered through two previous waves of data collection. Self-reported health data on demographic, income and financial stressors, oil spill exposure, neighborhood context, social capital, health behaviors, trauma history, psychological symptoms, and physical health will be collected through telephone interviews. Repeat blood samples will be collected from up to 1058 women with baseline samples.