课题基金 / 基金详情

Development and function of inflammatory innate lymphoid cells

Development and function of inflammatory innate lymphoid cells
炎症先天淋巴细胞的发育和功能
批准号:
10533596
负责人:
Qi yang
金额:
$23.63万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-04-15 至 2023-03-31

项目摘要

项目成果

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中文摘要
翻译
项目总结/文摘
英文摘要
Project Summary/Abstract The goal of this project is to understand the mechanisms that control effector lymphocyte stability and plasticity, and how this regulation influences human health and disease. Recent studies indicate that innate lymphocytes possess substantial plasticity. The underlying mechanisms, and the implications for health and disease, remain unknown. Our preliminary data indicate that exposure to Notch signaling can elicit innate lymphocyte plasticity and train mature group-2 innate lymphoid cells (ILC2) to acquire the ability to co-produce large amounts of both ILC2- and ILC3- characteristic cytokines, thus converting natural ILC2 (nILC2) into plastic inflammatory ILC2 (iILC2). Our new data suggest that such plastic iILC2 are relatively enriched in the airway of patients with severe refractory asthma. In this project, we will use adoptive transfer, chromatin immunoprecipitation, and RNA sequencing experiments to explore the cellular and molecular mechanisms by which Notch signaling elicits ILC2 plasticity. We will also examine the capability of human and mouse iILC2 to mediate airway inflammation and hyperresponsiveness. Finally, we will investigate the association between the development of plastic iILC2 and the susceptibility to severe refractory asthma in human adult patients. Together, these experiments will shed light on the mechanisms that govern lymphocyte lineage stability and plasticity, and will inform strategies of targeted therapy to treat patients with asthma and other auto-immune and inflammatory disorders.
期刊论文(12)
专著(0)
科研奖励(0)
会议论文
Adventitial stromal cells and myofibroblasts recruit pro- and anti-inflammatory immune cells in allergic airway inflammation.
外膜基质细胞和肌成纤维细胞在过敏性气道炎症中招募促炎和抗炎免疫细胞。
DOI: 10.1111/all.15766
发表时间: 2023
期刊: Allergy
影响因子: 12.4
作者: [Xu,En, Cao,Gaoyuan, Yang,Zhi, Zhang,Yuanyue, Si,Youwen, Singh,Kunal, Jude,Joseph, An,StevenS, Koziol-White,CynthiaJ, PanettieriJr,ReynoldA, Yang,Qi]
通讯作者: Yang,Qi
DOI: 10.1186/s12974-021-02202-2
发表时间: 2021-07-06
期刊: Journal of neuroinflammation
影响因子: 9.3
作者: [Fung ITH, Zhang Y, Shin DS, Sankar P, Sun X, D'Souza SS, Song R, Kuentzel ML, Chittur SV, Zuloaga KL, Yang Q]
通讯作者: Yang Q
DOI: 10.1111/acel.13470
发表时间: 2021-10
期刊: Aging cell
影响因子: 7.8
作者: [D'Souza SS, Zhang Y, Bailey JT, Fung ITH, Kuentzel ML, Chittur SV, Yang Q]
通讯作者: Yang Q
DOI: 10.1038/s41590-022-01349-1
发表时间: 2022-12
期刊: NATURE IMMUNOLOGY
影响因子: 30.5
作者: [Zhang, Yuanyue, Bailey, Jacob T., Xu, En, Singh, Kunal, Lavaert, Marieke, Link, Verena M., D'Souza, Shanti, Hafiz, Alex, Cao, Jian, Cao, Gaoyuan, Sant'Angelo, Derek B., Sun, Wei, Belkaid, Yasmine, Bhandoola, Avinash, McGavern, Dorian B., Yang, Qi]
通讯作者: Yang, Qi
The development and function of aging-associate innate lymphoid cells in the choroid plexus
Function and regulation of mucosal associated invariant T cells in the lung
  • 批准号:
    10291011
  • 项目类别:
  • 资助金额:
    $5.82万
  • 财政年份:
    2021
  • 负责人:
    Qi yang
  • 依托单位:
Innate Lymphoid Cell Aging
Function and regulation of mucosal associated invariant T cells in the lung
国内基金
海外基金
PRNP调控巨噬细胞M2极化并减弱吞噬功能促进子宫内膜异位症进展的机制研究
  • 批准号:
    82371651
  • 项目类别:
    面上项目
  • 资助金额:
    49.00万元
  • 批准年份:
    2023
  • 负责人:
    赵栋
  • 依托单位:
CBP/p300-HADH轴在基础胰岛素分泌调节中的作用和机制研究
  • 批准号:
    82370798
  • 项目类别:
    面上项目
  • 资助金额:
    49.00万元
  • 批准年份:
    2023
  • 负责人:
    王晓
  • 依托单位:
配子生成素GGN不同位点突变损伤分子伴侣BIP及HSP90B1功能导致精子形成障碍的发病机理
  • 批准号:
    82371616
  • 项目类别:
    面上项目
  • 资助金额:
    49.00万元
  • 批准年份:
    2023
  • 负责人:
    姚晨成
  • 依托单位:
Idh3a作为线粒体代谢—表观遗传检查点调控产热脂肪功能的机制研究
  • 批准号:
    82370851
  • 项目类别:
    面上项目
  • 资助金额:
    48.00万元
  • 批准年份:
    2023
  • 负责人:
    包玉倩
  • 依托单位: