BLRD Research Career Scientist Award Application
BLRD 研究职业科学家奖申请
基本信息
- 批准号:10513328
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-10-01 至 2026-09-30
- 项目状态:未结题
- 来源:
- 关键词:ADRBK1 geneAdrenergic AgentsAdrenergic ReceptorAlzheimer&aposs DiseaseAmyloid beta-ProteinAngiotensinsAnimal ModelAsthmaAtrial FibrillationAwardBiosensorBrainCaliforniaCardiacCardiac MyocytesCardiac OutputCardiovascular DiseasesCardiovascular PhysiologyCardiovascular systemCell physiologyChronicChronic DiseaseChronic Obstructive Pulmonary DiseaseCirculationClinicalClinical TrialsCognitionCollaborationsComplexCyclic AMPCyclic AMP-Dependent Protein KinasesCyclic GMPDLG1 geneDataDepressed moodDevelopmentDiabetes MellitusDiseaseDrug ScreeningEFRACEmotionsEpinephrineFibrosisFunctional disorderFundingGRK5 geneGenesGeneticGenomicsGoalsGrantHealthHealth Care CostsHeart DiseasesHeart failureHomeostasisHormonesHumanHyperglycemiaHyperinsulinismImpairmentInflammationInflammatoryInsulinInsulin ReceptorInterleukin-1 betaInterventionInvestigationJointsLaboratoriesLearningLinkLongevityMembrane ProteinsMemoryMemory LossMentorsMetabolicMetabolic DiseasesMetabolic syndromeMetabolismMolecularMolecular TargetMuscle CellsNatureNerveNeurodegenerative DisordersNeurohormonesNeuronsNitric OxideOutcomePainParkinson DiseasePathogenesisPathologicPathway interactionsPatient CarePatientsPharmaceutical PreparationsPhysiciansPrevention strategyPrivatizationProstaglandinsProteinsProteomicsProtocols documentationQuality of lifeReceptor SignalingRegulationResearchResearch PersonnelRoleScienceScientistServicesSignal InductionSignal PathwaySignal TransductionSignaling MoleculeStressSynapsesSystemTherapeuticTherapeutic InterventionTissuesTransgenic ModelTranslatingUnited States National Institutes of HealthVeteransalpha synucleinbeta-2 Adrenergic Receptorsbeta-adrenergic receptorbiochemical toolscareerclinical practicecognitive functioncomorbiditycytokinedesensitizationdiabeticdiabetic patientflexibilityheart functionhormone regulationimprovedinhibitorinsightinsulin signalinginterestlive cell imagingmilitary veteranneurotoxicitynew therapeutic targetnovelnovel strategiesnovel therapeutic interventionprogramsprotein complexreceptorresponsesingle moleculespatiotemporalsynuclein
项目摘要
The overall goal of my research is to understand mechanisms underlying pathophysiology in chronic
diseases, in particular heart failure (HF) and Alzheimer’s disease (AD). I aim to discover unknowns, establish
new paradigms, and identify novel targets for drug screening and clinical therapy. We apply integrative
approaches that include single molecule analysis, live-cell imaging, genomic and proteomic analysis, and
transgenic model animals to understand the fundamentals of intracellular signaling networks and their functional
roles in development of diseases. Over the past 16 years, I have received continuous funding from NIH, VA, and
private agencies. I am currently supported by two NIH R01 grants, a VA merit award, and a joint California
TRDRP grant. The results from my laboratory have significantly deepened our understanding of signaling
regulation and offered novel therapeutic targets for HF and AD. Through these endeavors, I have received an
AHA established investigator award in 2010 and established myself as a global leader in cardiac signaling
transduction.
In the early years, my research focuses on novel features of cardiac beta-adrenergic receptor (bAR)
signaling such as spatiotemporal regulation of cAMP-PKA cascades in cardiac contractile function. Over the past
10 years, I have expanded my research program to understand regulatory signaling networks in disease
development under chronic conditions such as inflammation and metabolic disorders. One of the highlights is
that we have described a membrane protein complex of insulin receptor (InsR) and b2AR broadly expressed in
different tissues. Activation of b2AR and InsR are critical regulatory mechanisms of both cardiovascular function
and metabolism. These receptors also modulate cognitive function including memory and learning, pain, emotion
and stress in the central nerve system. Dysregulation of these receptor signaling pathways has been linked to
development of HF and AD. Our recent studies have opened an exciting avenue in understanding cardiovascular
complications and neurodegenerative diseases associated with diabetes and metabolic syndromes. Several
active projects below are supported by ongoing funding from NIH and VA. The current VA merit grant aims to
characterize the essential roles of two proteins GRK5 and SAP97 in reduction (desensitization) of adrenaline
stimulation of a signaling molecule nitric oxide to enhance cardiac output. We will find how this regulation goes
wrong in heart diseases and thus offers novel strategies to treat heart diseases.
我研究的总体目标是了解慢性阻塞性肺疾病的病理生理机制
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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YANG K XIANG其他文献
YANG K XIANG的其他文献
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{{ truncateString('YANG K XIANG', 18)}}的其他基金
Phosphodiesterases govern nuclear cAMP signaling for gene expression
磷酸二酯酶控制基因表达的核 cAMP 信号传导
- 批准号:
10717183 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Desensitization of beta1 adrenergic receptor-nitric oxide signaling in cardiac diseases
心脏病中β1肾上腺素受体-一氧化氮信号的脱敏
- 批准号:
10367949 - 财政年份:2021
- 资助金额:
-- - 项目类别:
Desensitization of beta1 adrenergic receptor-nitric oxide signaling in cardiac diseases
心脏病中β1肾上腺素受体-一氧化氮信号的脱敏
- 批准号:
10618826 - 财政年份:2021
- 资助金额:
-- - 项目类别:
Molecular Regulation of cardiac adrenergic signaling
心脏肾上腺素信号传导的分子调节
- 批准号:
10425249 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Molecular Regulation of cardiac adrenergic signaling
心脏肾上腺素信号传导的分子调节
- 批准号:
9922716 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Molecular Regulation of cardiac adrenergic signaling
心脏肾上腺素信号传导的分子调节
- 批准号:
10155584 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Novel mechanism on subpopulation-dependent biased GPCR signaling in neurons
神经元亚群依赖性偏向 GPCR 信号传导的新机制
- 批准号:
10174956 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Novel mechanism on subpopulation-dependent biased GPCR signaling in neurons
神经元亚群依赖性偏向 GPCR 信号传导的新机制
- 批准号:
9929881 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Novel mechanism on subpopulation-dependent biased GPCR signaling in neurons
神经元亚群依赖性偏向 GPCR 信号传导的新机制
- 批准号:
10372289 - 财政年份:2018
- 资助金额:
-- - 项目类别:
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肾上腺素能药物治疗AD疗效的临床前试验
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甲基苯丙胺肾上腺素药物:门诊试验
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