Socio-spatial Networks and Tuberculosis Infection in Youth in Rural Uganda

项目概要/摘要 儿童和青少年结核病（TB）的负担是巨大的， 4，6 - 8，10扩大家庭以外结核病控制的新战略 进入社区，儿童获得估计80%的新结核病感染，11-12 needed.然而，对青年人在何处和从谁那里获得结核病以及这些结核病是如何传播的不完全了解， 驱动因素在整个生命早期过程中不断变化，阻碍了新干预措施的设计。因此，我们建议 有史以来第一个具有人口代表性的纵向结核感染发病率队列，对象为1至18岁的青年， 在乌干达的农村社区。使用流行病学和网络分析技术相结合， 研究将解决3个社会空间网络中有关结核病传播的关键基础知识差距， 青年：家庭网络、非家庭社会网络（密切接触者）和休闲网络 在社区场所遇到的联系人。在目标1中，我们将描述家庭社会 结核病感染在整个生命早期过程中的网络。在目标2中，我们将使用社会网络分析， 评估儿童和青少年结核病感染与其社区社会 在目标3中，我们将使用基于位置的网络来评估社区之间的关系。 场所和青少年结核病感染事件。来自该提案的数据将直接告知新颖的，特定年龄的， 这将有助于加强以社区为基础的结核病控制战略，并将有助于优化现有的以家庭为基础的战略。

PROJECT SUMMARY/ABSTRACT The burden of tuberculosis (TB) in children and adolescents is massive and current TB control strategies, even at full scale-up, are insufficient to address it.4,6-8,10 Novel strategies to expand TB control outside of the home and into the community, where children acquire an estimated 80% of new TB infections,11-12 are urgently needed. However, an incomplete understanding of where and from whom youth acquire TB, and how these drivers change throughout the early life-course, hampers the design of novel interventions. Thus, we propose the first-ever population-representative, longitudinal TB Infection Incidence Cohort of youth ages 1 to 18 years, in rural communities in Uganda. Using a combination of epidemiologic and network analytic techniques, this study will address key foundational knowledge gaps about TB transmission within 3 socio-spatial networks of youth: the household network, the non-household social network (close contacts), and the network of casual contacts encountered in community venues. In Aim 1 we will characterize the role of the household social network in TB infection throughout the early life course. In Aim 2 we will employ social network analysis to assess the relationships between child and adolescent TB infections and their community-based social network, and in Aim 3 we will use location-based networks to assess the relationships between community venues and incident TB infections in youth. Data from this proposal will directly inform novel, age-specific, community-based TB control strategies and will help optimize existing household-based strategies.