Socio-spatial Networks and Tuberculosis Infection in Youth in Rural Uganda

乌干达农村青年的社会空间网络与结核病感染

• 批准号: 10303055
• 负责人: Carina Marquez
• 金额: $ 67.02万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-11-16 至 2025-10-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10303055
• 关键词: 17 year old; Address; Adolescence; Adolescent; Adult; Africa; Africa South of the Sahara; Age; Age-Years; Baseline Surveys; Biological Assay; Case-Control Studies; Characteristics; Child; Cohort Studies; Communities; Data; Disease; Epidemic; Epidemiology; Foundations; HIV; Home; Hour; Household; Incidence; Infection; Intervention; Interview; Investigation; Knowledge; Life Cycle Stages; Location; Longitudinal cohort study; Measurement; Measures; Methodology; Methods; Molecular; Network-based; Outcome; Pathway Analysis; Persons; Population; Prevalence; Research Infrastructure; Role; Rural; Rural Community; School-Age Population; Social Network; Socialization; Source; Structure; Surveys; Techniques; Television; Testing; Time; Tuberculin Test; Tuberculosis; Uganda; Ursidae Family; Variant; Work; Youth; age group; base; burden of illness; case control; case finding; cohort; density; design; early childhood; epidemiology study; insight; novel; novel strategies; population based; preference; prospective; rural area; scale up; secondary analysis; sex; social; therapy design; transmission process; young adult

PROJECT SUMMARY/ABSTRACT The burden of tuberculosis (TB) in children and adolescents is massive and current TB control strategies, even at full scale-up, are insufficient to address it.4,6-8,10 Novel strategies to expand TB control outside of the home and into the community, where children acquire an estimated 80% of new TB infections,11-12 are urgently needed. However, an incomplete understanding of where and from whom youth acquire TB, and how these drivers change throughout the early life-course, hampers the design of novel interventions. Thus, we propose the first-ever population-representative, longitudinal TB Infection Incidence Cohort of youth ages 1 to 18 years, in rural communities in Uganda. Using a combination of epidemiologic and network analytic techniques, this study will address key foundational knowledge gaps about TB transmission within 3 socio-spatial networks of youth: the household network, the non-household social network (close contacts), and the network of casual contacts encountered in community venues. In Aim 1 we will characterize the role of the household social network in TB infection throughout the early life course. In Aim 2 we will employ social network analysis to assess the relationships between child and adolescent TB infections and their community-based social network, and in Aim 3 we will use location-based networks to assess the relationships between community venues and incident TB infections in youth. Data from this proposal will directly inform novel, age-specific, community-based TB control strategies and will help optimize existing household-based strategies.

项目总结/文摘