BLR&D Research Career Scientist Award Application

BLR

• 批准号: 10516018
• 负责人: DIDIER MERLIN
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2025-09-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10516018
• 关键词: Adult; Affect; Anti-Inflammatory Agents; Award; Cellular biology; Child; Colitis; Collaborations; Colorectal Cancer; Crohn' s disease; Data; Development; Diagnosis; Digestive System Disorders; Discipline; Disease; Doctor of Philosophy; Environment; Etiology; Faculty; Focus Groups; Fostering; Foundations; Future; Gastroenterology; General Population; Grant; Healthcare; Inflammatory Bowel Diseases; Interdisciplinary Study; Intestines; Journals; K-Series Research Career Programs; Laboratories; Medical center; Mission; Molecular Biology; Mucosal Immunity; Nanotechnology; Neurofibromin 2; Pathogenesis; Pathologic; Patients; Peptides; Physicians; Population; Productivity; Publishing; Research; Research Personnel; Science; Scientist; Seminal; Series; Structure; Techniques; Training; Transcend; United States National Center for Health Statistics; Universities; Veterans; Work; candidate selection; career; clinical care; colitis associated cancer; gut inflammation; improved; indexing; interest; lectures; meetings; member; military veteran; next generation; novel; novel therapeutic intervention; programs; symposium; training opportunity; treatment strategy

D. Merlin Ph.D, Summary Our research program is directed toward understanding the pathogenesis of intestinal inflammation and formulating treatment strategies for intestinal inflammatory diseases such as IBD. Our work has been published consistently in reputable journals and cited extensively (December 20, 2017: h-index of 45). Our laboratory is familiar with a vast number of techniques, from nanotechnology to molecular biology to cell biology. Over one million adults and children in the US, including members of the VA population, suffer from IBD, with about 50,000 new cases diagnosed each year, according to the Crohn’s and Colitis Foundation of America. VA IBD patients have a much higher rate of colorectal cancer compared to the general population (2.9% vs. 0.1%, according to the National Center for Health Statistics). New therapeutic strategies based on a better understanding of the pathogenesis of IBD will improve the clinical care of veteran and non-veteran patients with this disorder. We have long recognized the value of interdisciplinary research in furthering scientific discovery, as important research ideas often transcend the scope of a single discipline or program. In this context, we have promoted collaborative interdisciplinary research between scientists/physicians with interests in gastroenterology at the Atlanta VA Medical Center and scientists at the Institute for Biomedical Sciences of Georgia State University. These multidisciplinary collaborations are intended to develop novel ideas that will enhance the diagnosis and treatment of colitis and colitis-associated cancers that affect the VA population. 1

D. Merlin Ph.D，总结 我们的研究项目旨在了解肠道炎症的发病机制， 制定肠炎症性疾病如IBD的治疗策略。我们的工作已经发表 在知名期刊上持续发表，并被广泛引用（2017年12月20日：h指数为45）。本实验室 熟悉大量的技术，从纳米技术到分子生物学到细胞生物学。通过一 在美国，包括VA人群在内的数百万成年人和儿童患有IBD，其中约50，000人 根据美国克罗恩病和结肠炎基金会的数据，VA IBD患者 与普通人群相比，结肠直肠癌的发病率要高得多（2.9%对0.1%，根据 国家卫生统计中心（National Center for Health Statistics）。新的治疗策略基于对 IBD发病机制的研究将改善退伍军人和非退伍军人患者的临床护理。我们 我早就认识到跨学科研究在促进科学发现方面的价值， 研究思想往往超越单一学科或项目的范围。在这方面，我们促进了 科学家/医生之间的合作跨学科研究与胃肠病学的兴趣，在 亚特兰大退伍军人医疗中心和格鲁吉亚州立大学生物医学研究所的科学家。 这些多学科的合作旨在开发新的想法，将加强诊断和 治疗影响VA人群的结肠炎和结肠炎相关癌症。 1