BLR&D Research Career Scientist Award Application

BLR

• 批准号: 10047290
• 负责人: DIDIER MERLIN
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2025-09-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10047290
• 关键词: Adult; Affect; Americas; Anti-Inflammatory Agents; Award; Cellular biology; Child; Colitis; Collaborations; Colorectal Cancer; Data; Development; Diagnosis; Digestive System Disorders; Discipline; Disease; Doctor of Philosophy; Environment; Etiology; Faculty; Focus Groups; Fostering; Foundations; Future; Gastroenterology; General Population; Grant; Healthcare; Inflammatory Bowel Diseases; Institutes; Interdisciplinary Study; Intestines; Journals; K-Series Research Career Programs; Laboratories; Medical center; Mission; Molecular Biology; Mucosal Immunity; Nanotechnology; Neurofibromin 2; Pathogenesis; Pathologic; Patients; Peptides; Physicians; Population; Publishing; Research; Research Personnel; Science; Scientist; Seminal; Series; Structure; Techniques; Training; Transcend; United States National Center for Health Statistics; Universities; Veterans; Work; base; career; clinical care; colitis associated cancer; improved; indexing; inflammatory disease of the intestine; interest; large bowel Crohn' s disease; lectures; meetings; member; military veteran; next generation; novel; novel therapeutic intervention; programs; symposium; training opportunity; treatment strategy

D. Merlin Ph.D, Summary Our research program is directed toward understanding the pathogenesis of intestinal inflammation and formulating treatment strategies for intestinal inflammatory diseases such as IBD. Our work has been published consistently in reputable journals and cited extensively (December 20, 2017: h-index of 45). Our laboratory is familiar with a vast number of techniques, from nanotechnology to molecular biology to cell biology. Over one million adults and children in the US, including members of the VA population, suffer from IBD, with about 50,000 new cases diagnosed each year, according to the Crohn’s and Colitis Foundation of America. VA IBD patients have a much higher rate of colorectal cancer compared to the general population (2.9% vs. 0.1%, according to the National Center for Health Statistics). New therapeutic strategies based on a better understanding of the pathogenesis of IBD will improve the clinical care of veteran and non-veteran patients with this disorder. We have long recognized the value of interdisciplinary research in furthering scientific discovery, as important research ideas often transcend the scope of a single discipline or program. In this context, we have promoted collaborative interdisciplinary research between scientists/physicians with interests in gastroenterology at the Atlanta VA Medical Center and scientists at the Institute for Biomedical Sciences of Georgia State University. These multidisciplinary collaborations are intended to develop novel ideas that will enhance the diagnosis and treatment of colitis and colitis-associated cancers that affect the VA population. 1

梅林博士，总结