HILIGHT: Highly Integrated Versatile Laser Source enabling two-photon excitation in digital diagnostics and biomedical research

亮点：高度集成的多功能激光源可在数字诊断和生物医学研究中实现双光子激发

• 批准号: 10107542
• 金额: $ 68.39万
• 依托单位: BRUNEL UNIVERSITY LONDON
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10107542
• 关键词: HILIGHT; Highly; Integrated; Versatile; Laser

The overall objective of HILIGHT is to implement innovative solutions into versatile light sources and systems as tools for biomedical and healthcare applications centred around two-photon excitation fluorescence lifetime measurements and imaging microscopy. We propose two specific use cases: i) instantaneous digital histopathology and ii) biomedical research in the context of cancer research and diagnostics. HILIGHT proposes a miniaturised and versatile optical pulse burst source together with innovative sensing technology that will permit us to overcome those limitations in SoA instrumentation that often confine the use of two-photon microscopy and timeresolved detection to the specialist laboratory. We envisage that the HILIGHT innovations could disrupt activities in various fields and a range of market segments, including academic and research institutions, biotechnology, and medical facilities. These include applications targeted to improve our understanding of the molecular mechanisms of disease using in vivo, ex vivo, or 3D organotypic cultures, with the ultimate aim of developing better tools for fast and early diagnosis and more effective therapeutic interventions. HILIGHT is structured around nine work packages covering the whole value chain, coherently with the concept of the project standing on strong enabling technology foundations and targeting biophotonic and medical application domains. HILIGHT consortium is made up of five leading partners from various fields experienced in European collaborative projects and from five different European countries (FR, DE, IT, CH and UK). HILIGHT is built on several prior and ongoing successful collaborations between partners, which provides a strong guarantee for successful interaction within the consortium, and a smooth implementation of the workplan.

Hilight的总体目的是将创新的解决方案实施到多功能光源和系统中，作为围绕两光子激发荧光荧光寿命测量和成像显微镜的生物医学和医疗保健应用的工具。我们提出了两个特定用例：i）瞬时数字组织病理学和ii）在癌症研究和诊断方面的生物医学研究。 Hilight提出了一种微型和多功能的光学脉冲爆发来源以及创新的传感技术，这将使我们能够克服SOA仪器中的这些局限性，通常将两光子显微镜的使用局限于专业实验室。我们设想，Hilight Innovations可能会破坏各个领域的活动以及一系列细分市场，包括学术和研究机构，生物技术和医疗设施。其中包括针对我们使用体内，体内或3D器官培养物来提高我们对疾病分子机制的理解的应用，其最终目的是开发更好的工具，以快速和早期诊断和更有效的治疗干预措施。 Hilight围绕着覆盖整个价值链的九个工作包的结构，与该项目的概念一致，该项目站在强大的技术基础上，并针对生物量和医疗应用领域。 Hilight Consortium由来自欧洲合作项目和五个不同欧洲国家（FR，DE，IT，IT，CH和UK）的五个领导伙伴组成。 Hilight建立在合作伙伴之间的几个先前和持续的成功合作之上，该合作伙伴为在财团内的成功互动提供了强有力的保证，以及对工作计划的平稳实施。