Rat Genome Database
大鼠基因组数据库
基本信息
- 批准号:10519368
- 负责人:
- 金额:$ 200.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-09-30 至 2026-12-31
- 项目状态:未结题
- 来源:
- 关键词:ATAC-seqAnimal ModelAnimalsBiologicalBiological ProcessCatalogsCellsCollaborationsCommunitiesComparative StudyComplementComplexCross PresentationDataData SetDiseaseDisease modelEcosystemEnvironmentFundingFunding AgencyGenesGeneticGenetic DiseasesGenetic MarkersGenetic Predisposition to DiseaseGenetic VariationGenomeGenomicsGoalsHealthHeart DiseasesHematological DiseaseHumanHuman BiologyHybridsInfrastructureInternationalInvestmentsKnowledgeLengthLung diseasesManualsMapsMethodsMiningMissionModelingMolecularMultiomic DataMusNuclear RNANucleic Acid Regulatory SequencesOntologyOrganismOrthologous GenePhenotypePhysiologicalPopulationPre-Clinical ModelProcessQuantitative Trait LociRNARat Genome DatabaseRat StrainsRattusRegulationRegulator GenesResearchResearch PersonnelResourcesSleep DisordersSyntenySystemTestingTimeTranscriptTranslationsUnited States National Institutes of HealthVariantVisualizationWidespread Diseasecomparativedata integrationdata resourceepigenomeepigenomicsflexibilitygene functiongenetic informationgenetic variantgenome resourcegenome sequencinggenome wide association studygenomic datagenomic locushuman datahuman diseasehuman modelimprovedin silicoinsightmembermodel organismmodel organisms databasesmultiple datasetsmultiple omicsmutantnovelphenotypic datapre-clinicalreference genomeresearch studyspecies differencetooltool developmenttranscriptomewhole genome
项目摘要
Project Summary
The Rat Genome Database (RGD) has evolved substantially from a catalog of rat genetic markers, maps, and
genes to a comprehensive resource with multiple genomic data types, extensive disease and phenotype
annotations, and tools to effectively mine, analyze and visualize the available data. The goal of RGD is to enable
investigators in their hypothesis-driven research. Leveraging its robust and flexible infrastructure, RGD has
added data from human and other important human disease model organisms to enhance its translational
aspect. RGD is also one of the founding members of the Alliance of Genome Resources (Alliance), a consortium
of the major model organism databases focused on harmonizing and presenting cross-species information.
Since 2019, there has been an exciting reinvigoration in the rat genomics community and research. Through
collaboration with the Wellcome Sanger Institute, a new and vastly improved rat reference genome (mRatBN7.2)
has been generated and released, and RGD joined the Genome Reference Consortium (GRC) to curate it.
Several complementary NIH-funded projects focused on generating whole genome, transcriptome, and
epigenome sequencing datasets are underway in numerous rat strains representing human disease models;
several strains, including key models of heart, lung, blood and sleep disorders will have strain-specific, muli-omic
data and de novo genome assemblies. RGD has the unique opportunity to be the center of data integration for
these new, unique datasets, the overall theme of this renewal. To continue increasing the value of RGD and
build on the investments made by the NIH and other international funding bodies in rat research, we will develop
an extensive ecosystem for integration of multi-omics and biological data in the rat as a model of common human
complex disease and create a comprehensive comparative species platform to predict precision preclinical
human disease models for further study by research community.
项目摘要
大鼠基因组数据库(Rat Genome Database,RGD)是从大鼠遗传标记、图谱和
基因到一个全面的资源与多种基因组数据类型,广泛的疾病和表型
注释和工具来有效地挖掘、分析和可视化可用数据。RGD的目标是使
研究人员在他们的假设驱动的研究。利用其强大而灵活的基础设施,
增加了来自人类和其他重要人类疾病模式生物的数据,以增强其翻译能力。
方面. RGD也是基因组资源联盟(Alliance)的创始成员之一,该联盟是一个财团
主要模式生物数据库的一部分侧重于协调和提供跨物种信息。
自2019年以来,大鼠基因组学社区和研究出现了令人兴奋的复苏。通过
与Wellcome桑格研究所合作,一个新的和大大改进的大鼠参考基因组(mRatBN 7.2)
已经生成并发布,并且RGD加入了基因组参考联盟(GRC)来策划它。
几个补充NIH资助的项目集中在产生全基因组,转录组,
表观基因组测序数据集正在许多代表人类疾病模型的大鼠品系中进行;
几种菌株,包括心脏,肺,血液和睡眠障碍的关键模型,将具有菌株特异性,多组学
数据和从头基因组组装。RGD有独特的机会成为数据集成的中心,
这些新的,独特的数据集,这次更新的总主题。为了继续提高RGD的价值,
在美国国立卫生研究院和其他国际资助机构对大鼠研究的投资的基础上,我们将开发
一个广泛的生态系统,用于整合大鼠的多组学和生物学数据,作为普通人类的模型
复杂的疾病,并创建一个全面的比较物种平台,以预测精确的临床前
供研究界进一步研究的人类疾病模型。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ANNE E. KWITEK其他文献
ANNE E. KWITEK的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ANNE E. KWITEK', 18)}}的其他基金
Identification of a metabolic syndrome transcriptome signature in the LH rat
LH 大鼠代谢综合征转录组特征的鉴定
- 批准号:
8098029 - 财政年份:2010
- 资助金额:
$ 200.9万 - 项目类别:
Identification of a metabolic syndrome transcriptome signature in the LH rat
LH 大鼠代谢综合征转录组特征的鉴定
- 批准号:
7963802 - 财政年份:2010
- 资助金额:
$ 200.9万 - 项目类别:
Dissecting the genetics of the Metabolic Syndrome on Chromosome 17 of the LH rat
剖析 LH 大鼠 17 号染色体代谢综合征的遗传学
- 批准号:
7624320 - 财政年份:2008
- 资助金额:
$ 200.9万 - 项目类别:
Dissecting the genetics of the Metabolic Syndrome on Chromosome 17 of the LH rat
剖析 LH 大鼠 17 号染色体代谢综合征的遗传学
- 批准号:
7460150 - 财政年份:2008
- 资助金额:
$ 200.9万 - 项目类别:
Dissecting the genetics of the Metabolic Syndrome on Chromosome 17 of the LH rat
剖析 LH 大鼠 17 号染色体代谢综合征的遗传学
- 批准号:
8066351 - 财政年份:2008
- 资助金额:
$ 200.9万 - 项目类别:
Dissecting the genetics of the Metabolic Syndrome on Chromosome 17 of the LH rat
剖析 LH 大鼠 17 号染色体代谢综合征的遗传学
- 批准号:
7825390 - 财政年份:2008
- 资助金额:
$ 200.9万 - 项目类别:
Dissecting the genetics of the Metabolic Syndrome on Chromosome 17 of the LH rat
剖析 LH 大鼠 17 号染色体代谢综合征的遗传学
- 批准号:
8411732 - 财政年份:2008
- 资助金额:
$ 200.9万 - 项目类别:
Application of Genetics and Physiological Genomics to Dissect Resistance to T1D
应用遗传学和生理基因组学剖析 T1D 抗性
- 批准号:
6990084 - 财政年份:2005
- 资助金额:
$ 200.9万 - 项目类别:
相似海外基金
Quantification of Neurovasculature Changes in a Post-Hemorrhagic Stroke Animal-Model
出血性中风后动物模型中神经血管变化的量化
- 批准号:
495434 - 财政年份:2023
- 资助金额:
$ 200.9万 - 项目类别:
Bioactive Injectable Cell Scaffold for Meniscus Injury Repair in a Large Animal Model
用于大型动物模型半月板损伤修复的生物活性可注射细胞支架
- 批准号:
10586596 - 财政年份:2023
- 资助金额:
$ 200.9万 - 项目类别:
A Comparison of Treatment Strategies for Recovery of Swallow and Swallow-Respiratory Coupling Following a Prolonged Liquid Diet in a Young Animal Model
幼年动物模型中长期流质饮食后吞咽恢复和吞咽呼吸耦合治疗策略的比较
- 批准号:
10590479 - 财政年份:2023
- 资助金额:
$ 200.9万 - 项目类别:
Small animal model for evaluating the impacts of cleft lip repairing scar on craniofacial growth and development
评价唇裂修复疤痕对颅面生长发育影响的小动物模型
- 批准号:
10642519 - 财政年份:2023
- 资助金额:
$ 200.9万 - 项目类别:
Diurnal grass rats as a novel animal model of seasonal affective disorder
昼夜草鼠作为季节性情感障碍的新型动物模型
- 批准号:
23K06011 - 财政年份:2023
- 资助金额:
$ 200.9万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Longitudinal Ocular Changes in Naturally Occurring Glaucoma Animal Model
自然发生的青光眼动物模型的纵向眼部变化
- 批准号:
10682117 - 财政年份:2023
- 资助金额:
$ 200.9万 - 项目类别:
A whole animal model for investigation of ingested nanoplastic mixtures and effects on genomic integrity and health
用于研究摄入的纳米塑料混合物及其对基因组完整性和健康影响的整体动物模型
- 批准号:
10708517 - 财政年份:2023
- 资助金额:
$ 200.9万 - 项目类别:
A Novel Large Animal Model for Studying the Developmental Potential and Function of LGR5 Stem Cells in Vivo and in Vitro
用于研究 LGR5 干细胞体内外发育潜力和功能的新型大型动物模型
- 批准号:
10575566 - 财政年份:2023
- 资助金额:
$ 200.9万 - 项目类别:
Elucidating the pathogenesis of a novel animal model mimicking chronic entrapment neuropathy
阐明模拟慢性卡压性神经病的新型动物模型的发病机制
- 批准号:
23K15696 - 财政年份:2023
- 资助金额:
$ 200.9万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
The effect of anti-oxidant on swallowing function in an animal model of dysphagia
抗氧化剂对吞咽困难动物模型吞咽功能的影响
- 批准号:
23K15867 - 财政年份:2023
- 资助金额:
$ 200.9万 - 项目类别:
Grant-in-Aid for Early-Career Scientists