Rat Genome Database

项目摘要 大鼠基因组数据库(RGD)基本上是从大鼠遗传标记、图谱和 基因到具有多种基因组数据类型、广泛的疾病和表型的综合资源 注释，以及有效挖掘、分析和可视化可用数据的工具。RGD的目标是实现 研究人员在他们的假设驱动的研究中。利用其强大而灵活的基础设施，RGD 添加了来自人类和其他重要的人类疾病模型生物的数据，以增强其翻译 纵横比。RGD也是基因组资源联盟(Alliance)的创始成员之一，该联盟是一个联盟 在主要的模式生物数据库中，重点是协调和提供跨物种信息。 自2019年以来，老鼠基因组学界和研究领域出现了一场激动人心的复兴。穿过 与惠康·桑格研究所合作，一种新的大幅改进的大鼠参考基因组(mRatBN7.2) 已经生成并发布，RGD加入了基因组参考联盟(GRC)来管理它。 美国国立卫生研究院资助的几个互补性项目专注于生成全基因组、转录组和 表观基因组测序数据集正在许多代表人类疾病模型的大鼠品系中进行； 几种菌株，包括心脏、肺、血液和睡眠障碍的关键模型，将具有菌株特异性、多型性 数据和从头开始的基因组组合。RGD拥有成为以下项目数据集成中心的独特机会 这些新的、独特的数据集，是这次更新的总体主题。继续增加RGD的价值和 在美国国立卫生研究院和其他国际资助机构对老鼠研究的投资的基础上，我们将开发 作为普通人模型的大鼠多组学和生物学数据整合的广泛生态系统 复杂疾病和创建一个全面的比较物种平台，以预测精确的临床前 供研究界进一步研究的人类疾病模型。

Project Summary The Rat Genome Database (RGD) has evolved substantially from a catalog of rat genetic markers, maps, and genes to a comprehensive resource with multiple genomic data types, extensive disease and phenotype annotations, and tools to effectively mine, analyze and visualize the available data. The goal of RGD is to enable investigators in their hypothesis-driven research. Leveraging its robust and flexible infrastructure, RGD has added data from human and other important human disease model organisms to enhance its translational aspect. RGD is also one of the founding members of the Alliance of Genome Resources (Alliance), a consortium of the major model organism databases focused on harmonizing and presenting cross-species information. Since 2019, there has been an exciting reinvigoration in the rat genomics community and research. Through collaboration with the Wellcome Sanger Institute, a new and vastly improved rat reference genome (mRatBN7.2) has been generated and released, and RGD joined the Genome Reference Consortium (GRC) to curate it. Several complementary NIH-funded projects focused on generating whole genome, transcriptome, and epigenome sequencing datasets are underway in numerous rat strains representing human disease models; several strains, including key models of heart, lung, blood and sleep disorders will have strain-specific, muli-omic data and de novo genome assemblies. RGD has the unique opportunity to be the center of data integration for these new, unique datasets, the overall theme of this renewal. To continue increasing the value of RGD and build on the investments made by the NIH and other international funding bodies in rat research, we will develop an extensive ecosystem for integration of multi-omics and biological data in the rat as a model of common human complex disease and create a comprehensive comparative species platform to predict precision preclinical human disease models for further study by research community.