IgE antibodies to the mammalian oligosaccharide galactose-alpha-1, 3-galactose (alpha-gal): immunology, epidemiology and relevance to allergic and inflammatory disease

哺乳动物寡糖半乳糖-α-1, 3-半乳糖 (α-gal) 的 IgE 抗体：免疫学、流行病学以及与过敏性和炎症性疾病的相关性

• 批准号: 10518418
• 负责人: THOMAS A. PLATTS-MILLS
• 金额: $ 62.28万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10518418
• 关键词: Abdomen; Allergic; Allergic Disease; Allergic Reaction; Amblyomma; Ambylomma americanum; Antibodies; Area; Australia; Awareness; B-Lymphocytes; Biological Assay; Bite; Blinded; Blood typing procedure; Cardiac; Cardiology; Circulation; Clinical; Clinical Management; Coronary Angiography; Coronary Arteriosclerosis; Data; Disease; Eating; Eosinophilic Esophagitis; Epidemiology; Epitopes; Food; Food Hypersensitivity; Grant; Heparin; IgE; Immune response; Immunologics; Immunology; Inflammatory; Instruction; Investigation; Irritable Bowel Syndrome; Knock-out; Mammals; Meat; Medicine; Oligosaccharides; Patients; Placebos; Reaction; Reporting; Risk; Serology; Solenopsis invicta; Source; Symptoms; Syndrome; Ticks; United States; Virginia; blood group; design; galactosyl-(1-3)galactose; gastrointestinal; improved; meetings; novel; response; technique development; tick bite

Our ongoing and proposed studies are focused on understanding the causes and consequences of the IgE response to the oligosaccharide galactose alpha-1,3-galactose (?-gal) which is a major blood group substance of non-primate mammals. These studies are focused on three areas. (i) Understanding the epidemiology and clinical management of the delayed allergic reactions that occur after eating mammalian products which are referred to as the ?-gal syndrome (AGS). While the syndrome clearly relates to the distribution of the lone star ticks, Amblyomma americanum, there is increasing evidence that fire ants can interfere with this tick in the south and also that the range of this tick is moving northwards in the USA. We plan to use assays to identify the ?-gal epitope in food and medicinal products, e.g. CroFab and heparin. There are many such items that have some connection to mammalian source materials and could be contaminated. (ii) Full investigation of the serology and cellular responses related to AGS including comparison with other forms of food allergy. These studies will continue investigating the cellular basis of the immune response and cellular responses related to AGS using recent development of the technique of spectral flow analysis. In addition, we propose to extend these studies to a comparison with other forms of food allergy in particular with Eosinophilic Esophagitis, which like AGS has only become common over the last 30 years but is immunologically and clinically completely different. (iii) Detailed studies on two situations, where patients with IgE to ?-gal develop either abdominal symptoms or coronary artery disease without any symptoms that are typically regarded as allergic. Evidence about these two conditions has developed recently. The relationship to cardiac risk was first reported in 2018 and similar data has recently been reported to a cardiology meeting in Sydney, Australia. Furthermore investigation of B cells in the circulation of patients undergoing coronary angiography in Virginia has provided evidence supporting the relevance of B cells to the cardiac risk of ?-gal. The abdominal cases also make up a major percentage of the cases of irritable bowel syndrome (IBS) in areas of the USA where bites from the lone star tick are common e.g. Central Virginia. Our plan is to carry out challenges in these cases with pork meat using ?-gal knock-out pork as a blinded placebo to further investigate the evidence for the association and to further understand the delayed clinical reactions to red meat.

我们正在进行的和拟议的研究集中在了解的原因和后果

项目成果

Trajectory of IgG to SARS-CoV-2 After Vaccination With BNT162b2 or mRNA-1273 in an Employee Cohort and Comparison With Natural Infection.

• DOI: 10.3389/fimmu.2022.850987
• 发表时间: 2022
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Keshavarz B;Richards NE;Workman LJ;Patel J;Muehling LM;Canderan G;Murphy DD;Brovero SG;Ailsworth SM;Eschenbacher WH;McGowan EC;Mann BJ;Nelson MR;Kadl A;Woodfolk JA;Platts-Mills TAE;Wilson JM
• 通讯作者: Wilson JM

House dust sensitivity and environmental control.

室内灰尘敏感性和环境控制。

• 发表时间: 1987
• 期刊: Primary care
• 影响因子: 1.9
• 作者: Pollart,SM;Chapman,MD;Platts-Mills,TA
• 通讯作者: Platts-Mills,TA

The effects of cage design on airborne allergens and endotoxin in animal rooms: high-volume measurements with an ion-charging device.

笼子设计对动物房空气中过敏原和内毒素的影响：使用离子充电装置进行大容量测量。

• 发表时间: 2005
• 期刊: Contemporary topics in laboratory animal science
• 作者: Platts-Mills,James;Custis,Natalie;Kenney,Alice;Tsay,Amy;Chapman,Martin;Feldman,Sanford;Platts-Mills,Thomas
• 通讯作者: Platts-Mills,Thomas

Specific allergens evoking immune reactions in the lung: relationship to asthma.

引起肺部免疫反应的特定过敏原：与哮喘的关系。

• 发表时间: 1991
• 期刊: The European respiratory journal. Supplement
• 作者: Platts-Mills,TA;Chapman,MD;Pollart,S;Luczynska,CM;WardJr,GW
• 通讯作者: WardJr,GW

Chemical treatment of carpets to reduce allergen: a detailed study of the effects of tannic acid on indoor allergens.

• DOI: 10.1016/0091-6749(94)90066-3
• 发表时间: 1994-07
• 期刊: The Journal of allergy and clinical immunology
• 作者: J. Woodfolk;M. L. Hayden;Jeffrey D. Miller;G. Rose;Martin D. Chapman;ThomasA. E. Platts-Mills