ASTHMA AND BREATHLESSNESS IN SCHOOL AGE CHILDREN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 50名12-19岁的高中生(30名MD诊断为肥胖哮喘患者，转诊到疑似哮喘的调查者诊所或通过广告转介，以及20名非哮喘对照)将在医院环境中进行试点研究，以调查呼吸困难、肥胖和哮喘之间的关系。 我们的假设是，肥胖儿童抱怨呼吸困难的很大一部分原因是解除条件，而不是哮喘。因此，炎症介质的图谱将反映这一趋势，显示哮喘患者Th2过敏性炎症介质数量增加，而肥胖和非哮喘患者Th1炎症介质数量增加。这些炎性标志物图谱有可能被用作一种诊断工具，帮助区分哮喘患者和那些刚刚脱离疾病的患者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A pilot study enrolling 50 High School students age 12-19 (30 MD diagnosed, obese asthmatics, referred to the investigaors' clinic for suspected asthma or by advertisement and 20 non-asthmatic controls) will be conducted in a hospital setting to investigate the relationship between breathlessness, obesity, and asthma. Our hypothesis is that a significant portion of obese children complaining of breathlessness will be due to deconditioning rather than asthma. Accordingly, the profile of the inflammatory mediators will reflect such a trend by showing increased amounts of Th2, allergic inflammatory mediators in asthmatics while increased amounts of Th1 inflammatory mediators in obese, non-asthmatics. It is possible that these inflammatory marker profiles could be used as a diagnostic tool to help distinguish subjects with asthma from those who are only deconditioned.