ASTHMA AND BREATHLESSNESS IN SCHOOL AGE CHILDREN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 将在医院环境中进行一项试点研究，招募50名12-19岁的高中学生（30名诊断为MD的肥胖哮喘患者，因疑似哮喘或通过广告转诊至研究者诊所，20名非哮喘对照），以研究呼吸困难、肥胖和哮喘之间的关系。 我们的假设是，相当一部分肥胖儿童抱怨呼吸困难将是由于失调，而不是哮喘。 因此，炎症介质的分布将通过显示哮喘患者中Th 2、过敏性炎症介质的量增加而肥胖非哮喘患者中Th 1炎症介质的量增加来反映这种趋势。 这些炎症标志物谱可能用作诊断工具，以帮助区分哮喘受试者和仅失适应的受试者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A pilot study enrolling 50 High School students age 12-19 (30 MD diagnosed, obese asthmatics, referred to the investigaors' clinic for suspected asthma or by advertisement and 20 non-asthmatic controls) will be conducted in a hospital setting to investigate the relationship between breathlessness, obesity, and asthma. Our hypothesis is that a significant portion of obese children complaining of breathlessness will be due to deconditioning rather than asthma. Accordingly, the profile of the inflammatory mediators will reflect such a trend by showing increased amounts of Th2, allergic inflammatory mediators in asthmatics while increased amounts of Th1 inflammatory mediators in obese, non-asthmatics. It is possible that these inflammatory marker profiles could be used as a diagnostic tool to help distinguish subjects with asthma from those who are only deconditioned.