Bio-engineering Insect-Specific Flaviviruses for control of arboviruses

用于控制虫媒病毒的生物工程昆虫特异性黄病毒

• 批准号: FT200100221
• 负责人: Dr Yin Xiang Setoh
• 金额: --
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-06-29 至 2021-07-14
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT200100221
• 关键词: Bio; engineering; Insect; Specific; Flaviviruses

This project aims to study a family of commensal viruses of mosquitoes called insect-specific flaviviruses that are naturally found in mosquitoes and do not infect or cause disease in vertebrate hosts. Using an innovative approach, this project employs cutting-edge molecular virology approaches to modify these insect-specific flaviviruses to enhance their ability to block the replication of other pathogenic viruses in the mosquito vector. Expected outcome of this project is a bio-control strategy that is complementary to the Wolbachia approach. The anticipated benefits include the advancement of knowledge of insect-specific flaviviruses, and promotion of interdisciplinary research across the fields of Entomology and Virology.

该项目旨在研究一种称为昆虫特异性黄病毒的蚊子体内病毒家族，这种病毒自然存在于蚊子体内，不会感染脊椎动物宿主或引起疾病。该项目采用创新的方法，采用尖端的分子病毒学方法来修饰这些昆虫特异性黄病毒，以增强其阻断蚊子载体中其他致病病毒复制的能力。这一项目的预期成果是一项生物控制战略，它是对沃尔巴克氏体方法的补充。预期的好处包括昆虫特异性黄病毒知识的进步，以及促进昆虫学和病毒学领域的跨学科研究。