Administrative Core

行政核心 摘要 行政核心将领导、管理和支持获得性治疗抵抗的所有活动 胰腺癌网络 (ARTNet) 中心 (ACPC)。它将在跨 ARTNet 网络中代表 ACPC 活动以及与 NCI 的互动。 ARTNet 管理核心将负责管理 ACPC 项目与科学技术专业知识和资源的协同研究活动 治疗耐药性、信号传导、代谢、胰腺癌生物学、类器官和小鼠模型等领域， 免疫和非免疫基质以及 PDAC 组织，用于研究癌症的获得性治疗耐药性。的 核心领导层将提供从基础到转化领域的专业知识，与 ACPC 的总体主题，拥有建立和指导大型科学团队成功的记录 以变革性的方式推进领域。我们将以创新的方式运用战略管理， 包括将新人才带入该领域的教育部分，让多元化的团队参与进来，以促进新的 想法，利用与拟议目标相关的国家人才，让大学领导层建立支持 尖端科学，并利用专门的大学专业知识来促进基础和 转化研究项目以培养以 ARTNet 为中心的兴趣。行政核心将提供支持 参与行政、协调、沟通、生物统计和生物信息学的人员 支持中心和校园内的 ARTNet 活动、其他 ARTNet 中心、ARTNet 协调数据 管理中心 (CDMC) 和国家癌症研究所 (NCI)。行政核心还将提供 与总体相关的科学监督、结果传播、预算监督和文书职能 此 ACPC 应用程序中的研究计划。核心将实施中心范围的活动，其中包括： 在 ACPC 项目上开展新的合作，组织年度静修会，支持获得性癌症治疗 各个学术单位的抵抗研讨会发言人，倡导下一代科学家 ACPC 成员实验室的（研究生、博士后研究人员和初级教师）。最后， 行政核心将在 ARTNet 指导委员会中代表 ACPC。

ADMINISTRATIVE CORE Abstract The administrative core will lead, manage, and support all activities of the Acquired Resistance to Therapy Network (ARTNet) Center for Pancreatic Cancer (ACPC). It will represent ACPC at the trans-ARTNet network activities, and in interactions with NCI. The ARTNet administrative core will be responsible for managing the activities of the synergistic research ACPC projects with scientific and technical expertise and resources in the areas of therapy resistance, signaling, metabolism, pancreatic cancer biology, organoid and mouse models, immune and non-immune stroma, and PDAC tissues for studying the acquired therapy resistance in cancer. The core leadership will provide expertise spanning the basic to translational spectrum, consistent with the overarching theme of ACPC, with track records of building and guiding large scientific teams to successfully advance fields in transformative ways. We will utilize strategic management with innovative approaches, including an educational component to bring new talent into the field, engage diverse teams to facilitate new ideas, leverage national talent pertinent to the proposed goals, engage university leadership in building support for cutting-edge science, and utilize dedicated university expertise to facilitate engagement with basic and translational research programs to grow ARTNet centric interests. The administrative core will provide support for personnel involved in the administration, coordination, communication, biostatistics, and bioinformatics to support the ARTNet activities within the center and campus, other ARTNet centers, ARTNet Coordinating Data and Management Center (CDMC) and National Cancer Institutes (NCI). The administrative core will also provide scientific oversight, result dissemination, budgetary oversight, and clerical functions associated with the overall research program in this ACPC application. The core will implement center-wide activities which include, developing new collaborations on the ACPC projects, organize annual retreat, support acquired cancer therapy resistance seminar speakers within various academic units, advocate for the next generation of scientists (graduate students, postdoctoral researchers, and junior faculty) in the ACPC member laboratories. Finally, the administrative core will represent ACPC on the ARTNet steering committee.