Administrative Core

摘要_管理核心 U19应用程序的目标是了解睡眠过程中流体和溶质清除的神经回路控制 神经活动如何推动动脉周围脑脊液流入，从而跨时间清除淋巴废物，微观 宏观空间尺度和物种。该项目汇集了神经计算方面的专家， 神经血管耦合、睡眠、人类神经成像、流体动力学和建模，有很长的记录 富有成效的合作。 行政核心将作为协调U19计划所有方面的枢纽 功能。它的主要目标是促进思想交流和互动，并促进科学 节目的卓越之处。管理核心还将监督数据核心在 U19计划和外部社区。核心将对该计划的所有方面进行财政监督，并 执行内部审查委员会(也由项目和核心领导组成)作出的决定 作为项目经理)和外部顾问委员会(由6名国际公认的科学家组成 具有协作研究和数据共享/建模方面的经验)。行政核心的任务之一是 不断调整数据科学和病毒工具开发核心的使用，以最大限度地支持 这4个项目。行政核心还将组织并向国家卫生研究院提交年度进展报告。这个 核心基金将组织方案内的所有例行会议，包括核心工作人员会议、内部和 外部咨询委员会会议、跨机构行政会议、年度会议和 实地考察。最后，行政核心将优化个人助理、协作教师、博士、 硕士、本科生以及研究人员，以培养以团队为基础的科学和 促进频繁的实验室交流和学员科学发展的机会。 总而言之，管理核心的雄心是确保整个项目按照 尽可能高效地达到研究目标，并满足联邦和机构的所有要求 规章制度。我们的目标是第一次了解协调的神经活动是如何驱动清除 睡眠中的液体和溶质；并与更广泛的神经科学界分享我们的想法、数据和 研究工具。

Abstract_Administrative Core The goal of the U19 application “Neural circuit control of fluid and solute clearance during sleep” is to understand how neural activity drives periarterial CSF inflow and thereby glymphatic waste clearance across time, micro- macroscopic spatial scales, and species. The program brings together experts in neural computation, neurovascular coupling, sleep, human neuroimaging, fluid dynamics, and modeling, with a long track record of productive collaborations. The Administrative Core will serve as the hub that will coordinate all aspects of the U19 program functions. Its major goal is to facilitate the exchange of ideas and interactions and to promote the scientific excellence of the program. The Administrative Core will also oversee that the Data Core shares data within the U19 program and the outside community. The Core will provide fiscal oversight of all aspects of the program and implement decisions made by the Internal Review Committee (consisting of the project and core leaders as well as the program manager) and the External Advisory Board (consisting of 6 internationally recognized scientists with experience in collaborative studies and data sharing/modeling). One of the Administrative Core’s tasks is to continuously adjust the use of the Data Science and Viral Tool Development Cores to maximize their support of the 4 projects. The Administrative Core will also organize and submit the annual progress reports to NIH. The Core Facility will organize all routine meetings within the program, including core staff meetings, the Internal and External Advisory Board meetings, the cross-institutional administrative meetings, the annual meeting, and the site visits. Finally, the Administrative Core will optimize communication between PIs, collaborating faculty, PhD, MS, and undergraduate students, as well as research staff, to foster a team-based approach to science and facilitate frequent lab exchanges and opportunities for trainee scientific development. Altogether, the ambitions of the Administrative Core are to ensure that the overall project runs as efficiently as possible to reach the research goals and fulfills all requirements of federal and institutional regulations. Our goals are to understand, for the first time, how coordinated neural activity drives clearance of fluid and solutes during sleep; and to share with the greater neuroscience community our ideas, data, and research tools.