One Health approach to understand, predict and prevent viral emergencies from bats

一种了解、预测和预防蝙蝠病毒紧急情况的健康方法

• 批准号: 10109347
• 金额: $ 41.62万
• 依托单位: UNIVERSITY OF SUSSEX
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10109347
• 关键词: Health; approach; understand; predict; prevent

In recent years, several novel RNA viruses found in bats have been associated to the emergence of human diseases. Surveillance in this extremely diverse group of mammals has revealed that bats are significant reservoir hosts for many viruses whose zoonotic potential deserves further insights. OneBAT aims at investigating the trigger for viral spillover from European bats to humans or domestic animals, using a multidisciplinary consortium of ecologists, virologists and modellers. In response to the outcomes foreseen by the call, OneBAT will unravel the complex interplay between natural and spillover host, pathogen and environment that determines the emergence of infectious diseases. Information on viral replication pathways, antigenic markers, and in vitro and in vivo screening of antivirals will advance the availability of current and future therapeutic and prophylactic tools for Disease X. Due to technical and logistical reasons, OneBAT will not investigate all the batspecies and pathogens circulating in Europe; it will rather provide well-based evidence on relevant model species that could be used to study other bat species or viruses that already are or may become of interest over the lifetime of the project or in the future. We will focus on the Miniopterus schreibersii bats, a species in significant decline across Europe, and on filoviruses, coronaviruses and lyssaviruses, as high-consequence pathogens known to circulate in the target bat. In addition to the specific information stemming from the project, OneBAT will establish a methodological platform that will make available the developed ecological and virological tools. Among them, innovative protocols for serological and virological investigations of these small-seize animals; harmonised longitudinalsurveys across Europe, including tracking systems. Ultimately, OneBAT will equip southern and eastern EU countries with 20 VHF receivers that could be used for further studies on all flying animals.

近年来，在蝙蝠中发现的几种新型RNA病毒与人类疾病的出现有关。对这一极其多样化的哺乳动物群体的监测表明，蝙蝠是许多病毒的重要储存宿主，这些病毒的人畜共患病潜力值得进一步了解。OneBAT旨在利用生态学家、病毒学家和建模人员组成的多学科联盟，调查欧洲蝙蝠向人类或家畜传播病毒的触发因素。为了响应这一呼吁所预见的结果，OneBAT将揭示自然和溢出宿主、病原体和环境之间复杂的相互作用，这种相互作用决定了传染病的出现。关于病毒复制途径、抗原标记物以及抗病毒药物的体外和体内筛选的信息将促进当前和未来疾病X的治疗和预防工具的可用性。由于技术和后勤方面的原因，OneBAT将不会调查在欧洲传播的所有蝙蝠物种和病原体;它将提供有关模型物种的基础充分的证据，可用于研究其他蝙蝠物种或病毒，这些物种或病毒在项目期间或未来已经或可能会引起人们的兴趣。我们将专注于Miniopterus schreibersii蝙蝠，一个物种在整个欧洲显着下降，并对丝状病毒，冠状病毒和狂犬病毒，作为已知的高后果病原体在目标蝙蝠循环。除了项目产生的具体信息外，OneBAT还将建立一个方法平台，提供开发的生态和病毒学工具。其中包括对这些小型动物进行血清学和病毒学调查的创新方案;协调欧洲各地的兽医调查，包括跟踪系统。最终，OneBAT将为欧盟南部和东部国家配备20个VHF接收器，可用于进一步研究所有飞行动物。