Leveraging omics data to understand sleep health and its consequences among diverse Hispanics/Latinos

利用组学数据了解不同西班牙裔/拉丁裔的睡眠健康及其后果

• 批准号: 10516256
• 负责人: Tamar Sofer
• 金额: $ 73.76万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10516256
• 关键词: Address; Affect; Alzheimer' s Disease; Atherosclerosis Risk in Communities; Automobile Driving; Behavioral; Biological; Biological Markers; Central American; Clinical; Cognitive; Collection; Communities; Cuban; Data; Data Set; Development; Diabetes Mellitus; Disease; Disease Outcome; Dominican; Educational workshop; Environment; Epigenetic Process; Frequencies; Genes; Genetic; Genetic Determinism; Genetic Risk; Geographic Locations; Goals; Health; High Prevalence; Hispanic Community Health Study/Study of Latinos; Hispanic Populations; Hypertension; Impaired cognition; Individual; Interdisciplinary Study; Intervention; Latino; Latino Population; Life Style; Link; Longitudinal cohort study; Measures; Mediation; Methylation; Mexican; Modification; Morbidity - disease rate; Multi-Ethnic Study of Atherosclerosis; National Heart, Lung, and Blood Institute; Neurocognitive; Obesity; Outcome; Outcome Study; Pathway interactions; Patients; Phenotype; Population; Predisposition; Primary Prevention; Puerto Rican; Research; Research Methodology; Risk; Risk Factors; Site; Sleep; Sleep Disorders; South American; Testing; Vascular Dementia; Work; base; cardiometabolism; cardiovascular risk factor; cognitive function; cohort; diabetes risk; disorder risk; experience; health disparity; improved; innovation; lifestyle factors; metabolomics; methylation biomarker; modifiable risk; multidimensional data; multiple omics; polygenic risk score; public health intervention; resilience; sex; sleep health; social; social culture

PROJECT SUMMARY Hispanics/Latinos are the fastest growing demographic group in the U.S., expected to comprise 24% of the US population by 2060. Latinos experience high rates of health disparities, including a high burden of diabetes mellitus (DM), uncontrolled hypertension (HTN), obesity, and Alzheimer's Disease and vascular dementias. The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a longitudinal cohort study established in 2004, following ~16,500 US Latinos from four geographic areas and multiple Latino backgrounds (Mexican, South American, Central American, Cuban, Dominican, and Puerto Rican). We oversaw the collection and analysis of sleep measures during the HCHS/SOL baseline exam. Along with our colleagues, we identified a high prevalence of sleep disorders which varied by social and behavioral factors and Latino background, and were associated with incident DM, HTN, and cognitive decline and impairment. This project will apply integrative and multi-disciplinary research methods to study biological mechanisms that result in the sleep-related risk of DM, HTN, and cognitive decline across diverse Latinos. First, we will identify methylation and metabolomics measures associated with sleep phenotypes and characterize them biologically. We further identify a subset of these omics measures that are linked to modifiable lifestyle and sociocultural measures. Second, we will develop metabolomics and methylation biomarkers of sleep by combining information across multiple markers. We will study the association of such biomarkers with incident outcomes (DM, HTN, cognitive decline and impairment). Third, we will estimate the effect of sleep phenotypes on modifying genetic risks for DM, HTN, and cognitive outcomes using a gene-by-sleep interaction analysis with polygenic risk scores for each outcome. We will also perform multi-omics analyses synthesizing multiple omics measures to understand biological pathways. Finally, we will apply causal analysis to quantify the potential reduction in risks of incident DM, HTN, and cognitive decline and impairment following potential intervention on sleep phenotypes, under the assumption that metabolomics and genetic pathways can be blocked. We will estimate these effects in aggregate and across Latino backgrounds. Our work will lead to the development of public health interventions at the community-(e.g., in Latinos of Mexican origin) and patient-level by identifying individuals (e.g., based on specific genetic or metabolomic profiles) who would benefit most from improving their sleep.

项目摘要 西班牙裔/拉丁美洲人是美国增长最快的人群群体，预计将占美国的24％ 人口到2060年。拉丁美洲人的健康差异率很高，包括糖尿病负担很大 Mellitus（DM），不受控制的高血压（HTN），肥胖症和阿尔茨海默氏病和血管痴呆症。 西班牙裔社区健康研究/拉丁美洲人研究（HCHS/SOL）是一项纵向队列研究 2004年，来自四个地理区域和多个拉丁裔背景的约16,500个美国拉丁裔（墨西哥， 南美，中美洲，古巴，多米尼加和波多黎各人）。我们监督了该系列， HCHS/SOL基线检查期间的睡眠度量分析。与我们的同事一起，我们确定了 睡眠障碍的高患病率随社会和行为因素以及拉丁裔背景而异，以及 与DM，HTN和认知能力下降和损害有关。 该项目将应用综合和多学科研究方法来研究生物学机制 导致与睡眠有关的DM，HTN和不同拉丁美洲人的认知下降的风险。首先，我们将确定 甲基化和代谢组学测量与睡眠表型相关，并在生物学上表征它们。 我们进一步确定了与可修改的生活方式和社会文化有关的这些OMIC措施的子集 措施。其次，我们将通过合并来发展睡眠的代谢组学和甲基化生物标志物 跨多个标记的信息。我们将研究此类生物标志物与事件结果的关联 （DM，HTN，认知能力下降和损害）。第三，我们将估计睡眠表型对 使用基因逐囊相互作用分析来改变DM，HTN和认知结果的遗传风险 每个结果的多基因风险得分。我们还将执行多摩管分析合成多个OMICS 了解生物学途径的措施。最后，我们将应用因果分析来量化潜力 潜在干预后，DM，HTN和认知能力下降和损害的风险降低 在可以阻止代谢组和遗传途径的假设下，睡眠表型。我们将 估计这些效果在整个拉丁裔背景中。我们的工作将导致发展 通过识别社区的公共卫生干预措施（例如，在墨西哥起源的拉丁美洲人）和患者级别 个体（例如，基于特定的遗传或代谢概况），他们将从改善中受益最大 他们的睡眠。