Leveraging omics data to understand sleep health and its consequences among diverse Hispanics/Latinos
利用组学数据了解不同西班牙裔/拉丁裔的睡眠健康及其后果
基本信息
- 批准号:10850324
- 负责人:
- 金额:$ 66.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-01 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAlzheimer&aposs DiseaseAtherosclerosis Risk in CommunitiesAutomobile DrivingBehavioralBiologicalBiological MarkersCentral AmericanClinicalCognitiveCollectionCommunitiesCubanDataData SetDevelopmentDiabetes MellitusDiseaseDisease OutcomeDominicanEducational workshopEnvironmentEpigenetic ProcessFrequenciesGenesGeneticGenetic DeterminismGenetic RiskGeographic LocationsGoalsHealthHigh PrevalenceHispanic Community Health Study/Study of LatinosHispanic PopulationsHypertensionImpaired cognitionIndividualInterdisciplinary StudyInterventionLatinoLatino PopulationLife StyleLinkLongitudinal cohort studyMeasuresMediationMethylationMexicanModificationMorbidity - disease rateNational Heart, Lung, and Blood InstituteNeurocognitiveObesityOutcomePathway interactionsPhenotypePopulationPredispositionPrimary PreventionPuerto RicanResearchRiskRisk FactorsSiteSleepSleep DisordersSouth AmericanStudy of LatinosTestingVascular DementiaWorkcardiometabolismcardiovascular risk factorcognitive functioncohortdata integrationdiabetes riskdisorder riskexperiencehealth determinantshealth disparityimprovedimprovement on sleepinnovationlifestyle factorsmetabolomicsmethylation biomarkermodifiable riskmultidimensional datamultiple omicspolygenic risk scorepublic health interventionresilience factorsecondary analysissexsleep healthsocialsocial culturesociocultural determinant
项目摘要
PROJECT SUMMARY
Hispanics/Latinos are the fastest growing demographic group in the U.S., expected to comprise 24% of the US
population by 2060. Latinos experience high rates of health disparities, including a high burden of
cardiovascular risk factors, diabetes mellitus (DM), uncontrolled hypertension (HTN), obesity, and Alzheimer’s
Disease and vascular dementias. The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a
longitudinal cohort study established in 2004, following ~16,500 US Latinos from four geographic areas and
from multiple Latino backgrounds (Mexican, South American, Central American, Cuban, Dominican, and
Puerto Rican). We oversaw the collection and analysis of sleep measures during its baseline exam. Along with
our colleagues, we identified a high prevalence of sleep disorders which varied in frequency by social and
behavioral factors and Latino background, and associated with incident DM, HTN, and cognitive decline and
impairment.
In this project we will apply an integrative and multi-disciplinary research to study biological mechanisms that
result in sleep health-related risk of DM, HTN, and cognitive decline across diverse Latinos. First, we will
identify methylation and metabolomics measures associated with sleep phenotypes, and characterize them
biologically. We will link some of them to modifiable lifestyle and sociocultural measures. Second, we will
develop metabolomics and methylation biomarkers of sleep by combining information across multiple makers.
We will study the association such biomarkers with incident outcomes (DM, HTN, cognitive decline and
impairment). Third, we will estimate the effect of sleep phenotypes on modifying genetic risks for DM, HTN,
and cognitive outcomes using a gene-by-sleep interaction analysis with polygenic risk scores for each
outcome. We will also perform multi-omics analyses synthesizing multiple omics measures to understand
biological pathways. Finally, we will apply causal analysis to quantify the potential reduction in risks of incident
DM, HTN, and cognitive decline and impairment following potential intervention on sleep phenotypes, under
the assumption that metabolomics and genetic pathways can be blocked. We will estimate these effects in
aggregate and across Latino backgrounds. Our work will lead to development of public health interventions at
the community level (e.g., addressing strategies to improve sleep health) and at the personal level: by
identifying individuals who will benefit most from improving their sleep, for example, according to their genetics
or metabolomics profile.
项目摘要
拉美裔是美国增长最快的人口群体,预计将占美国的24%
到2060年人口。拉丁美洲人的健康差距率很高,包括高负担,
心血管危险因素、糖尿病(DM)、不受控制的高血压(HTN)、肥胖和阿尔茨海默病
疾病和血管性痴呆。西班牙裔社区健康研究/拉丁美洲人研究(HCHS/SOL)是一项
2004年建立的纵向队列研究,跟踪了来自四个地理区域的约16,500名美国拉丁美洲人,
来自多个拉丁美洲背景(墨西哥,南美,中美洲,古巴,多米尼加,
波多黎各)。我们在基线检查期间监督睡眠测量的收集和分析。沿着
我们的同事,我们确定了睡眠障碍的高患病率,其频率因社会和
行为因素和拉丁裔背景,并与事件DM,HTN和认知能力下降,
损伤
本课题将采用综合性、多学科的研究方法,研究生物学机制,
在不同的拉丁美洲人中,导致与睡眠健康相关的糖尿病、高血压和认知能力下降的风险。一是
确定与睡眠表型相关的甲基化和代谢组学指标,并对其进行表征
从生理上来说我们将把其中一些措施与可改变的生活方式和社会文化措施联系起来。二是
通过结合多个标记物的信息,开发睡眠的代谢组学和甲基化生物标志物。
我们将研究这些生物标志物与事件结局(DM、HTN、认知能力下降和
损伤)。第三,我们将评估睡眠表型对改变糖尿病、高血压、
和认知结果,使用基因与睡眠相互作用分析,
结果。我们还将进行多组学分析,综合多种组学措施,以了解
生物途径。最后,我们将应用因果分析来量化事故风险的潜在降低
糖尿病、高血压、认知功能下降和睡眠表型潜在干预后的损害,
代谢组学和遗传途径可以被阻断的假设。我们将估计这些影响,
在拉丁裔背景下的聚集。我们的工作将导致公共卫生干预措施的发展,
社区级别(例如,解决改善睡眠健康的策略)和个人层面:
例如,根据遗传学来确定哪些人将从改善睡眠中受益最大
或代谢组学图谱。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Tamar Sofer', 18)}}的其他基金
Using polygenic risk scores and omics to study how suboptimal sleep accelerates cognitive aging in diverse populations
使用多基因风险评分和组学研究次优睡眠如何加速不同人群的认知衰老
- 批准号:
10735647 - 财政年份:2023
- 资助金额:
$ 66.17万 - 项目类别:
Leveraging omics data to understand sleep health and its consequences among diverse Hispanics/Latinos
利用组学数据了解不同西班牙裔/拉丁裔的睡眠健康及其后果
- 批准号:
10516256 - 财政年份:2022
- 资助金额:
$ 66.17万 - 项目类别:
Using Genetic and Blood Metabolites to Understand the Risk of Alzheimer's Disease in Latinos
利用遗传和血液代谢物了解拉丁裔患阿尔茨海默病的风险
- 批准号:
10299916 - 财政年份:2021
- 资助金额:
$ 66.17万 - 项目类别:
Using Genetic and Blood Metabolites to Understand the Risk of Alzheimer's Disease in Latinos
利用遗传和血液代谢物了解拉丁裔患阿尔茨海默病的风险
- 批准号:
10845817 - 财政年份:2021
- 资助金额:
$ 66.17万 - 项目类别:
Leveraging Correlated Traits to Identify Genetic Associations with Sleep Disordered Breathing
利用相关特征来识别与睡眠呼吸障碍的遗传关联
- 批准号:
9814425 - 财政年份:2019
- 资助金额:
$ 66.17万 - 项目类别:
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