Melanocortin Receptor Selective Ligands

黑皮质素受体选择性配体

基本信息

  • 批准号:
    10517099
  • 负责人:
  • 金额:
    $ 1.85万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-07-01 至 2025-04-30
  • 项目状态:
    未结题

项目摘要

Obesity (body mass index, BMI >30) afflicts millions of people in the United States and other countries, and is a major risk factor for heart disease, type II diabetes mellitus, stroke, hypertension, and morbidity. The G-protein coupled melanocortin-3 receptor (MC3R) is expressed in the central nervous system (brain) and is part of the melanocortin pathway involved in the regulation of energy homeostasis. The specific role of the MC3R in the regulation of obesity has not been clearly defined due to a lack of receptor specific ligands and a complex metabolic phenotype of the MC3R knockout mouse. This project is focused upon the discovery of MC3R selective molecular probes (peptide and small molecules), in vitro lead candidate selection, and use of wild type and knockout mice for further molecule lead selection. The working hypothesis of this project is that the MC3R is directly involved in the regulation of food intake, satiety, and energy/metabolic homeostasis. It is anticipated that MC3R ligands have the potential to become therapeutic ligands for obesity related diseases that bypass the human melanocortin-4 receptor (MC4R) agonist associated side effects of male erectile activity and hypertension.
在美国和欧洲,数以百万计的人饱受肥胖(身体质量指数,BMI)的折磨

项目成果

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Marc Giulianotti其他文献

Marc Giulianotti的其他文献

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{{ truncateString('Marc Giulianotti', 18)}}的其他基金

Melanocortin Receptor Selective Ligands
黑皮质素受体选择性配体
  • 批准号:
    10296047
  • 财政年份:
    2021
  • 资助金额:
    $ 1.85万
  • 项目类别:
Melanocortin Receptor Selective Ligands
黑皮质素受体选择性配体
  • 批准号:
    10615117
  • 财政年份:
    2021
  • 资助金额:
    $ 1.85万
  • 项目类别:
Melanocortin Receptor Selective Ligands
黑皮质素受体选择性配体
  • 批准号:
    10430233
  • 财政年份:
    2021
  • 资助金额:
    $ 1.85万
  • 项目类别:
Melanocortin Receptor Selective Ligands
黑皮质素受体选择性配体
  • 批准号:
    10713372
  • 财政年份:
    2021
  • 资助金额:
    $ 1.85万
  • 项目类别:
Melanocortin Receptor Selective Ligands
黑皮质素受体选择性配体
  • 批准号:
    10557972
  • 财政年份:
    2021
  • 资助金额:
    $ 1.85万
  • 项目类别:

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