Interaction of genetic risk and early body mass index changes on neurodevelopmental disorders among Japanese children

这项研究旨在调查神经发育障碍(NDDS)的遗传风险与婴儿时期(出生至24个月)体重指数(BMI)变化之间的相互作用是否会影响日本儿童注意力缺陷/多动障碍(ADHD)和自闭症谱系障碍(ASD)的严重程度。研究人群包括1,258名来自滨松母婴出生队列的儿童，并有可用的后续信息。感兴趣的主要暴露是(1)出生至24个月期间BMI的变化，以及(2)NDDS的遗传风险。结果是：在6、8和12年测量ADHD和ASD的症状。完成了对6岁时评估结果的数据分析。此外，我们还对422名12岁的儿童进行了跟踪访谈。

This study aimed to investigate whether the interaction between genetic risk for neurodevelopmental disorders (NDDs) and changes in body mass index (BMI) during infancy (birth to 24 months) affects the severity of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) traits in Japanese children. The study population comprises 1,258 children from the Hamamatsu Birth Cohort for Mother and Child with available follow-up information. The main exposures of interest are (1) changes in BMI between birth and 24 months, and (2) genetic risk for NDDs. The outcomes are: symptoms of ADHD and ASD measured at 6, 8 and 12 years. Data analysis was completed for outcomes assessed at 6 years of age. Also, we conducted follow-up interviews among 422 children aged 12 years.