Interaction of genetic risk and early body mass index changes on neurodevelopmental disorders among Japanese children

日本儿童神经发育障碍的遗传风险和早期体重指数变化的相互作用

• 批准号: 21K17268
• 负责人: Rahman Md.Shafiur
• 金额: $ 2.83万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K17268/
• 关键词: Neurodevelopment; ADHD; ASD; body mass index; genetic risk; autism

This study aimed to investigate whether the interaction between genetic risk for neurodevelopmental disorders (NDDs) and changes in body mass index (BMI) during infancy (birth to 24 months) affects the severity of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) traits in Japanese children. The study population comprises 1,258 children from the Hamamatsu Birth Cohort for Mother and Child with available follow-up information. The main exposures of interest are (1) changes in BMI between birth and 24 months, and (2) genetic risk for NDDs. The outcomes are: symptoms of ADHD and ASD measured at 6, 8 and 12 years. Data analysis was completed for outcomes assessed at 6 years of age. Also, we conducted follow-up interviews among 422 children aged 12 years.

本研究旨在调查神经发育障碍（NDD）遗传风险与婴儿期（出生至24个月）体重指数（BMI）变化之间的相互作用是否会影响日本儿童注意力缺陷/多动障碍（ADHD）和自闭症谱系障碍（ASD）特征的严重程度。研究人群包括来自滨松母婴出生队列的1，258名儿童，并提供了随访信息。感兴趣的主要风险是（1）出生至24个月之间BMI的变化，以及（2）NDD的遗传风险。结果是：ADHD和ASD的症状在6岁，8岁和12岁时测量。完成了6岁时评估结果的数据分析。此外，我们对422名12岁的儿童进行了随访。

项目成果

Effect of perceived eye gaze on the N170 component ? A systematic review

感知眼睛注视对 N170 成分的影响？

• DOI: 10.1016/j.neubiorev.2022.104913
• 发表时间: 2022
• 期刊: Neuroscience & Biobehavioral Reviews
• 作者: Tautvydaite Domile;Mares Ines;Rahman Md. Shafiur;Burra Nicolas;Senju Atsushi
• 通讯作者: Senju Atsushi

Association between Body Mass Index and Risk of Gastric Cancer by Anatomic and Histologic Subtypes in Over 500,000 East and Southeast Asian Cohort Participants.

• DOI: 10.1158/1055-9965.epi-22-0051
• 发表时间: 2022-09-02
• 期刊: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
• 影响因子: 3.8
• 作者: Jang, Jieun;Lee, Sangjun;Ko, Kwang-Pil;Abe, Sarah K.;Rahman, Md. Shafiur;Saito, Eiko;Islam, Md. Rashedul;Sawada, Norie;Shu, Xiao-Ou;Koh, Woon-Puay;Sadakane, Atsuko;Tsuji, Ichiro;Kim, Jeongseon;Oze, Isao;Nagata, Chisato;Tsugane, Shoichiro;Cai, Hui;Yuan, Jian-Min;Gao, Yu-Tang;Ozasa, Kotaro;Matsuyama, Sanae;Kanemura, Seiki;Shin, Aesun;Ito, Hidemi;Wada, Keiko;Sugawara, Yumi;Chen, Yu;Ahsan, Habibul;Boffetta, Paolo;Chia, Kee Seng;Matsuo, Keitaro;Qiao, You-Lin;Rothman, Nathaniel;Zheng, Wei;Inoue, Manami;Kang, Daehee;Park, Sue K.
• 通讯作者: Park, Sue K.

Socioeconomic and education-based inequality in developmental delay among Nepalese children: a subnational level assessment (poster presentation)

尼泊尔儿童发育迟缓中基于社会经济和教育的不平等：国家以下各级评估（海报展示）

• 发表时间: 2023
• 作者: Iwabuchi T;Takahashi N;Nishimura T;Rahman MS;Harada T;Okumura A;Kuwabara H;Takagai S;Nomura Y;Matsuzaki H;Ozaki N;Tsuchiya KJ.;Md Shafiur Rahman
• 通讯作者: Md Shafiur Rahman

Long-term effect of persistent postpartum depression on children's psychological problems in childhood

• DOI: 10.1016/j.jad.2022.02.061
• 发表时间: 2022-03-08
• 期刊: JOURNAL OF AFFECTIVE DISORDERS
• 影响因子: 6.6
• 作者: Tainaka, Hanae;Takahashi, Nagahide;Tsuchiya, Kenji J.
• 通讯作者: Tsuchiya, Kenji J.

Perfluorooctanoate and perfluorooctane sulfonate in umbilical cord blood and child cognitive development: Hamamatsu Birth Cohort for Mothers and Children (HBC Study)

• DOI: 10.1016/j.envint.2022.107215
• 发表时间: 2022-05-01
• 期刊: ENVIRONMENT INTERNATIONAL
• 影响因子: 11.8
• 作者: Oh, Jiwon;Shin, Hyeong-Moo;Tsuchiya, Kenji J.
• 通讯作者: Tsuchiya, Kenji J.