Propylparaben effects on reproductive health of the aging female
对羟基苯甲酸丙酯对老年女性生殖健康的影响
基本信息
- 批准号:10526421
- 负责人:
- 金额:$ 7.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-12-01 至 2024-11-30
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAdultAffectAgeAgingAmericanAnimal ModelAntralApoptosisBeautyBeveragesBiologicalBiological AssayCancerousCell CountCell Cycle InhibitionCell Cycle ProgressionCell DeathCell DensityCell ProliferationChemical ExposureChemicalsChildChildbirthDataDermalDevelopmentDoseEndocrine DisruptorsEnvironmentEnzymesEpidemiologyEpithelial CellsEstradiolEvaluationExposure toFemaleFemale infertilityFertilityFertility StudyFollicle Stimulating HormoneFoodFunctional disorderFutureGonadal Steroid HormonesGrowthHalf-LifeHormonesHuman MilkImpairmentIn VitroInfertilityIngestionInhalationKnowledgeLifeLinkLong-Term EffectsMammalian OviductsMammary Gland ParenchymaMeasuresMedicalMedicineMethodsMolecularMusNeonatalOrganOutcomeOvarianOvarian FollicleOvaryParabensPathway interactionsPhysiologicalPredispositionPregnancy ComplicationsPremature Ovarian FailureProliferatingPublic HealthReproductive HealthRodentSamplingSecretory CellSerumSteroid biosynthesisTestingTissuesToxicologyUrineWomanWomen&aposs HealthWorkabsorptionantimicrobialchild bearingeconomic costepidemiology studyexperienceexperimental studyhormonal signalsidiopathic infertilityimprovedin vivoneglectnovelovarian reserveprematurepsychosocialreproductive hormonereproductive outcomereproductive senescencetherapy developmenttranscriptome sequencingtrendyoung adult
项目摘要
Female infertility is a major public health problem that affects about 10% of women and it is
estimated to affect 6.5 million American women by 2025. Additionally, rates of infertility are
expected to increase as women wait longer to have children. The main reasons of female infertility
relate to
ovarian, fallopian tube (oviduct), or idiopathic dysfunctions. Recent experimental and
epidemiological studies have linked some endocrine disrupting chemical exposures with female
infertility and premature reproductive aging. However, only some of these studies have examined
the reprotoxic effects of chemicals in daily-used products despite their relevance to women’s
health. Propylparaben, in particular, is an antimicrobial compound that is commonly incorporated
in numerous products and it is a suspected endocrine-disruptor. Limited experimental findings
indicate that it can target the ovary and to alter sex steroid hormone synthesis. However, these
studies mostly used neonatal and young adult rodents, examined short exposure durations, and
neglected the oviduct as a potential target of propylparaben. Henceforth, the proposed project
aims to determine the progressive effects of long-term exposure to propylparaben on ovarian and
oviductal function and overall fertility by using an animal model that closely mimic women’s
exposure and childbearing choices. Our central hypothesis is that long-term daily exposure to
propylparaben disrupts ovarian steroidogenesis and decreases oviductal epithelial cell turnover,
culminating with reduced fertility that is exacerbated by duration of exposure and dose (in vivo).
We propose to determine the reprotoxic effects of propylparaben on 1) ovarian steroidogenesis
and follicle development, 2) oviductal epithelial cell turnover, and overall fertility. To that end we
will utilize cutting-edge molecular and histomorphological methods along with hormone assays
and comprehensive fertility studies. We will compare three different doses of propylparaben and
durations of exposure that will mimic women’s exposure during three different childbearing ages.
The successful completion of the proposed project will provide both mechanistic and physiologic
findings on propylparaben reprotoxic effects on the ovary, oviduct, and overall fertility. Our
proposed studies may identify novel factors related to accelerated reproductive aging and
unexplained infertility. Findings from the proposed studies will improve women’s ability to make
informed choices about their reproductive health.
女性不孕症是影响约10%妇女的主要公共卫生问题,确实如此
项目成果
期刊论文数量(0)
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科研奖励数量(0)
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Matthew J Dean其他文献
Matthew J Dean的其他文献
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{{ truncateString('Matthew J Dean', 18)}}的其他基金
The Role of Uterine Glycogen in Establishing a Successful Pregnancy
子宫糖原在成功怀孕中的作用
- 批准号:
10725894 - 财政年份:2023
- 资助金额:
$ 7.93万 - 项目类别:
Deciphering the Roles of Endometrial Glycogen Reserves and the Impact of Obesity on Fertility
解读子宫内膜糖原储备的作用以及肥胖对生育力的影响
- 批准号:
10638028 - 财政年份:2023
- 资助金额:
$ 7.93万 - 项目类别:
Propylparaben effects on reproductive health of the aging female
对羟基苯甲酸丙酯对老年女性生殖健康的影响
- 批准号:
10373441 - 财政年份:2021
- 资助金额:
$ 7.93万 - 项目类别:
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