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Microscale Electrophysiology of Epileptic Cortex - Resubmission - 1

癫痫皮层的微观电生理学 - 重新提交 - 1

基本信息

批准号：
10527706
负责人：
Daniel Friedman
金额：
$ 25.05万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10527706
关键词：
Ablation Affect American Area Biological Markers Brain Brain region Clinical Collaborations Development Devices Diagnosis Diagnostic Diameter Electrocorticogram Electrodes Electroencephalography Electrophysiology (science)Engineering Epilepsy Event Excision Film Freedom Future Generations Heterogeneity Implant Intervention Intractable Epilepsy Investigation Link Measures Microelectrodes Modeling Monitor Morbidity - disease rate Neocortex Neurologic Neurons Operative Surgical Procedures Outcome Patients Phase Population Property Publishing Records Recurrence Resected Resolution Seizures Series Signal Transduction Site Surface Technology Testing Thinness Tissues Work brain tissue clinically significant density epileptiform experimental study improved interest liquid crystal polymer meter millimeter mortality neocortical nervous system disorder neurophysiology neurosurgery neurotechnology nonhuman primate novel response standard of care surgery outcome tumor

项目摘要

Project Summary Surgical treatment of epilepsy and seizures involves recording seizure activity to identify the seizure onset zone (SOZ), and resecting as much of the SOZ as possible. Existing approaches, such as electrocorticography (ECoG), define epileptogenic cortex – brain tissue with the potential to initiate seizures – but are inaccurate as 40-60% of patients do not achieve durable seizure freedom after resection/ablation. This outcome gap has spurred an interest in identifying novel neurophysiological biomarkers to identify brain regions for neurosurgical intervention to maximize the benefit of epilepsy surgery. Just as the macroscale organization of the epileptic brain is heterogenous with interconnected brain regions that contribute to seizure initiation and spread, the microscale organization of epileptogenic cortex is also heterogenous, containing sub-millimeter regions that can generate microscale inter-ictal activity between seizures. Microscale events may contribute to the generation of clinical seizures observed at standard macroscales but have not been investigated as they are not detectable in standard clinical ECoG recordings. Studying microscale events requires microscale µECoG recordings. Under other support, we have developed a novel electrode array that provides high-density microcontact recording of microscale events over large cortical areas, 1 cm2. The electrode records cortical surface potentials beyond the resolution and coverage of any currently clinically-available technology. For this R21 proposal, we propose to initiate a collaboration between a clinician and a neuroscientist-engineer to develop and test the multiscale properties of seizure networks. We propose to investigate the mechanistic and clinical implications of microscale epileptiform activity. We will focus on two predictions of the microscale model. Aim 1 tests the mechanistic prediction that inter-ictal µ-seizures share similar cellular mechanisms as ictal seizure events. Aim 2 tests the clinical significance of microscale recordings by examining the relationship of µ- seizures recording intra-operatively to cortex vulnerable to seizure initiation and early propagation identified in standard clinical recordings. Preliminary intraoperative studies in patients undergoing diagnostic monitoring demonstrates the feasibility of our approach. This R21 proposal will therefore identify the specific potential value, mechanistic and/or clinical, of studying microscale interictal events. The results will advance systematic investigations of the microscale electrophysiology of epileptogenic tissue more broadly.

项目总结