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Optimal Tissue Engineering Approach for Treating Injured Vocal Folds

治疗受损声带的最佳组织工程方法

基本信息

批准号：
10530598
负责人：
Donald O Freytes
金额：
$ 57.03万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-12-01 至 2024-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10530598
关键词：
Address American Anatomy Architecture Area Autologous Biocompatible Materials Biomechanics Bladder Cell Therapy Cells Cellular Structures Cicatrix Clinical Clinical Trials Communication impairment Data Disease Dysphonia Engineering Etiology Extracellular Matrix Fibroblasts Fibrosis Foundations Gel Human Hydrogels Impairment In Vitro Inflammation Inflammatory Injectable Injury Investigation Laboratories Lamina Propria Location Macrophage Mechanics Mesenchymal Stem Cells Methods Modality Mucous Membrane National Institute on Deafness and Other Communication Disorders Organ Outcome Outpatients Particulate Patient-Focused Outcomes Patients Persons Physiology Pliability Pre-Clinical Model Predisposition Procedures Process Production Public Health Reflux Regenerative response Reporting Role Site Small Intestinal Submucosa Source Stimulus Stomach Strategic Planning Structure Symptoms Therapeutic Therapeutic Effect Time Tissue Engineering Tissues Trauma Treatment Cost Voice Voice Disorders Wages Work biomaterial development clinical application clinical implementation clinical material clinical practice delivery vehicle experimental study functional restoration healing iatrogenic injury implantation improved in vitro activity in vivo individual variation injured insight minimally invasive novel regenerative repaired response response to injury scaffold stem cells vocal cord wound healing

项目摘要

PROJECT SUMMARY Voice impairment is the most common communication disorder with nearly 20 million people in the US reporting symptoms of dysphonia annually. The cost of treatment and lost wages for this disorder is approaching $13 billion. The etiology of these disorders is diverse, but given their anatomic location, the vocal folds (VFs) are susceptible to a multitude of injurious stimuli, including reflux of gastric contents, iatrogenic injury, and the inherent trauma associated with voice production. Injury can result in altered lamina propria (LP) architecture resulting in aberrant phonatory physiology. To date, no treatment restores the native VF extracellular matrix (ECM) composition, structure, and function following VF injury which likely underlies suboptimal outcomes for patients with VF scar. ECMs, if appropriately processed, can be used as resorbable, clinically safe, and naturally derived biomaterials that promote tissue remodeling while reducing fibrosis. Injectable ECM hydrogels are ideal for clinical application and cell delivery, particularly given the emerging practice and distinct advantages of in-office procedures using minimally invasive approaches. Work from our group and others provide promising data regarding the role of decellularized vocal fold lamina propria (VFLP-ECM) as an injectable agent or as a delivery vehicle for therapeutic cells such as mesenchymal stem cells. We broadly hypothesize that VFLP-ECM hydrogels (with or without stem cells) will promote functional repair of the VFs.

项目总结

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Porcine Vocal Fold Lamina Propria-Derived Biomaterials Modulate TGF-β1-Mediated Fibroblast Activation in Vitro.

DOI：
10.1021/acsbiomaterials.9b01837
发表时间：
2020-03-09
期刊：
ACS biomaterials science & engineering
影响因子：
5.8
作者：
Mora-Navarro C;Badileanu A;Gracioso Martins AM;Ozpinar EW;Gaffney L;Huntress I;Harrell E;Enders JR;Peng X;Branski RC;Freytes DO
通讯作者：
Freytes DO

Towards a standardized multi-tissue decellularization protocol for the derivation of extracellular matrix materials.

DOI：
10.1039/d2bm01012g
发表时间：
2023-01-17
期刊：
BIOMATERIALS SCIENCE
影响因子：
6.6
作者：
Biehl, Andreea;Martins, Ana M. Gracioso M.;Davis, Zachary G. G.;Sze, Daphne;Collins, Leonard;Mora-Navarro, Camilo;Fisher, Matthew B. B.;Freytes, Donald O. O.
通讯作者：
Freytes, Donald O. O.

Mast Cell-Biomaterial Interactions and Tissue Repair.

DOI：
10.1089/ten.teb.2020.0275
发表时间：
2020-11
期刊：
Tissue engineering. Part B, Reviews
影响因子：
0
作者：
E. Ozpinar;Ariana L. Frey;G. Cruse;D. Freytes
通讯作者：
E. Ozpinar;Ariana L. Frey;G. Cruse;D. Freytes

Fast Automated Approach for the Derivation of Acellular Extracellular Matrix Scaffolds from Porcine Soft Tissues.

DOI：
10.1021/acsbiomaterials.0c00265
发表时间：
2020-07-13
期刊：
ACS biomaterials science & engineering
影响因子：
5.8
作者：
Badileanu A;Mora-Navarro C;Gracioso Martins AM;Garcia ME;Sze D;Ozpinar EW;Gaffney L;Enders JR;Branski RC;Freytes DO
通讯作者：
Freytes DO

Monitoring decellularization via absorbance spectroscopy during the derivation of extracellular matrix scaffolds.