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Augmenting Vocal Fold Repair Using an Optimized Lamina Propria Extracellular Matrix Derived Hydrogel

使用优化的固有层细胞外基质衍生水凝胶增强声带修复

基本信息

批准号：
10614946
负责人：
Donald O Freytes
金额：
$ 57.96万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-04 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10614946
关键词：
Address Affect American Anatomy Architecture Area Biocompatible Materials Biomechanics Bladder Cells Cicatrix Clinical Communication impairment Data Derivation procedure Detergents Disease Dysphonia Engineering Etiology Extracellular Matrix Fibroblasts Fibrosis Gel Goals Human Hydrogels Impairment In Situ In Vitro Injectable Injury Investigation Laboratories Lamina Propria Link Location Macrophage Mechanics Methods Modeling Mucous Membrane National Institute on Deafness and Other Communication Disorders Oryctolagus cuniculus Outcome Patient Care Patient-Focused Outcomes Patients Performance Persons Physiology Pliability Pre-Clinical Model Predisposition Procedures Process Production Property Protocols documentation Public Health Reflux Reporting Research Role Small Intestinal Submucosa Stimulus Stomach Strategic Planning Structure Symptoms Testing Therapeutic Time Tissues Trauma Treatment Cost Voice Voice Disorders Wages Work biomaterial compatibility biomaterial development clinical application clinical practice cohort experimental study healing iatrogenic injury improved in vivo minimally invasive preclinical trial repaired reparative capacity response scaffold tissue repair vocal cord wound healing

项目摘要

PROJECT SUMMARY Voice impairment is the most common communication disorder with nearly 20 million people in the US reporting symptoms of dysphonia annually. The cost of treatment and lost wages for this disorder is approaching $13 billion. The etiology of these disorders is diverse, but given their anatomic location, the vocal folds (VFs) are susceptible to a multitude of injurious stimuli, including reflux of gastric contents, iatrogenic injury, and the inherent trauma associated with voice production. Injury can result in altered lamina propria (LP) architecture resulting in aberrant phonatory physiology. To date, no treatment restores the native VF extracellular matrix (ECM) composition, structure, and function following VF injury which likely underlies suboptimal outcomes for patients with VF scar. Extracellular matrix derived scaffolds, if appropriately processed, can be used as resorbable and naturally derived biomaterials with a safe record of clinical use that promote constructive tissue remodeling. Tissue- specific ECM hydrogels are ideal for clinical application, particularly given the emerging practice and distinct advantages of in-office procedures using minimally invasive approaches. Work from our group and others provide promising data regarding the role of decellularized vocal fold lamina propria (VFLP-ECM) as a therapeutic scaffold. We broadly hypothesize that VFLP-ECM will evolve into clinical practice to provide a scaffold that promotes functional repair of the VFs. Specifically, we seek to develop an injectable vocal fold lamina propria hydrogel (VFLP-ECMh) that will degrade over time while harnessing the stimulatory effects of the ECM to drive vocal fold tissue remodeling.

项目总结